ProfessorDavidDexter

Ward RJ, Lallemand F, de Witte P, Crichton RR, Piette J, Tipton K, Hemmings K, Pitard A, Page M, Della Corte L, Taylor D, Dexter Det al., 2011, Anti-inflammatory actions of a taurine analogue, ethane β-sultam, in phagocytic cells, <i>in vivo</i> and <i>in vitro</i>, BIOCHEMICAL PHARMACOLOGY, Vol: 81, Pages: 743-751, ISSN: 0006-2952

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• Citations: 15

Broom L, Marinova-Mutafchieva L, Sadeghian M, Davis JB, Medhurst AD, Dexter DTet al., 2011, Neuroprotection by the selective iNOS inhibitor GW274150 in a model of Parkinson disease, FREE RADICAL BIOLOGY AND MEDICINE, Vol: 50, Pages: 633-640, ISSN: 0891-5849

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• Citations: 72

Crichton RR, Dexter DT, Ward RJ, 2011, Brain iron metabolism and its perturbation in neurological diseases, JOURNAL OF NEURAL TRANSMISSION, Vol: 118, Pages: 301-314, ISSN: 0300-9564

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• Citations: 182

Ward RJ, Crichton RR, Taylor DL, Della Corte L, Srai SK, Dexter DTet al., 2011, Iron and the immune system, JOURNAL OF NEURAL TRANSMISSION, Vol: 118, Pages: 315-328, ISSN: 0300-9564

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• Citations: 83

Nalls MA, Plagnol V, Hernandez DG, Sharma M, Sheerin U-M, Saad M, Simon-Sanchez J, Schulte C, Lesage S, Sveinbjornsdottir S, Arepalli S, Barker R, Ben-Shlomo Y, Berendse HW, Berg D, Bhatia K, de Bie RMA, Biffi A, Bloem B, Bochdanovits Z, Bonin M, Bras JM, Brockmann K, Brooks J, Burn DJ, Charlesworth G, Chen H, Chinnery PF, Chong S, Clarke CE, Cookson MR, Cooper JM, Corvol JC, Counsell C, Damier P, Dartigues J-F, Deloukas P, Deuschl G, Dexter DT, van Dijk KD, Dillman A, Durif F, Duerr A, Edkins S, Evans JR, Foltynie T, Gao J, Gardner M, Gibbs JR, Goate A, Gray E, Guerreiro R, Gustafsson O, Harris C, van Hilten JJ, Hofman A, Hollenbeck A, Holton J, Hu M, Huang X, Huber H, Hudson G, Hunt SE, Huttenlocher J, Illig T, Jonsson PV, Lambert J-C, Langford C, Lees A, Lichtner P, Limousin P, Lopez G, Lorenz D, McNeill A, Moorby C, Moore M, Morris HR, Morrison KE, Mudanohwo E, O'Sullivan SS, Pearson J, Perlmutter JS, Petursson H, Pollak P, Post B, Potter S, Ravina B, Revesz T, Riess O, Rivadeneira F, Rizzu P, Ryten M, Sawcer S, Schapira A, Scheffer H, Shaw K, Shoulson I, Sidransky E, Smith C, Spencer CCA, Stefansson H, Stockton JD, Strange A, Talbot K, Tanner CM, Tashakkori-Ghanbaria A, Tison F, Trabzuni D, Traynor BJ, Uitterlinden AG, Velseboer D, Vidailhet M, Walker R, van de Warrenburg B, Wickremaratchi M, Williams N, Williams-Gray CH, Winder-Rhodes S, Stefansson K, Martinez M, Hardy J, Heutink P, Brice A, Gasser T, Singleton AB, Wood NWet al., 2011, Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies, LANCET, Vol: 377, Pages: 641-649, ISSN: 0140-6736

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• Citations: 697

Dexter DT, Statton SA, Whitmore C, Freinbichler W, Weinberger P, Tipton KF, Della Corte L, Ward RJ, Crichton RRet al., 2011, Clinically available iron chelators induce neuroprotection in the 6-OHDA model of Parkinson's disease after peripheral administration, JOURNAL OF NEURAL TRANSMISSION, Vol: 118, Pages: 223-231, ISSN: 0300-9564

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• Citations: 108

Dexter D, Allen R, Gillies G, Buckingham Jet al., 2010, Stress is a Predisposing Factor for Parkinson's Disease in Males but Not Females, MOVEMENT DISORDERS, Vol: 25, Pages: S619-S619, ISSN: 0885-3185

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Evans J, Durrenberger PF, Reynolds R, Gruenblatt E, Dexter DTet al., 2010, Promyelocytic Leukaemia Protein Inclusion Bodies in Parkinsonian Astrocytes, MOVEMENT DISORDERS, Vol: 25, Pages: S628-S628, ISSN: 0885-3185

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Aitchison K, Datla K, Rooprai H, Fernando J, Dexter Det al., 2010, Regional distribution of clomipramine and desmethylclomipramine in rat brain and peripheral organs on chronic clomipramine administration, JOURNAL OF PSYCHOPHARMACOLOGY, Vol: 24, Pages: 1261-1268, ISSN: 0269-8811

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• Citations: 14

Pienaar IS, Dexter DT, Burkhard PR, 2010, Mitochondrial proteomics as a selective tool for unraveling Parkinson's disease pathogenesis, EXPERT REVIEW OF PROTEOMICS, Vol: 7, Pages: 205-226, ISSN: 1478-9450

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• Citations: 17

Durrenberger PF, Fernando S, Kashefi SN, Ferrer I, Hauw J-J, Seilhean D, Smith C, Walker R, Al-Sarraj S, Troakes C, Palkovits M, Kasztner M, Huitinga I, Arzberger T, Dexter DT, Kretzschmar H, Reynolds Ret al., 2010, Effects of Antemortem and Postmortem Variables on Human Brain mRNA Quality: A BrainNet Europe Study, JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, Vol: 69, Pages: 70-81, ISSN: 0022-3069

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• Citations: 130

Chan H, Paur H, Vernon AC, Zabarsky V, Datla KP, Croucher MJ, Dexter DTet al., 2010, Neuroprotection and Functional Recovery Associated with Decreased Microglial Activation Following Selective Activation of mGluR2/3 Receptors in a Rodent Model of Parkinson's Disease, Parkinson's Disease, Vol: 2010, Pages: 1-12

<jats:p>Clinical trials have demonstrated positive proof of efficacy of dual metabotropic glutamate receptor 2/3 (mGluR2/3) agonists in both anxiety and schizophrenia. Importantly, evidence suggests that these drugs may also be neuroprotective against glutamate excitotoxicity, implicated in the pathogenesis of Parkinson's disease (PD). However, whether this neuroprotection also translates into functional recovery is unclear. In the current study, we examined the neuroprotective efficacy of the dual mGluR2/3 agonist, 2<jats:italic>R</jats:italic>,4<jats:italic>R</jats:italic>-4-aminopyrrolidine-2,4-dicarboxylate (2<jats:italic>R</jats:italic>,4<jats:italic>R</jats:italic>-APDC), and whether this is accompanied by behavioral recovery in a rodent 6-hydroxydopamine (6-OHDA) model of PD. We now report that delayed post lesion treatment with 2<jats:italic>R</jats:italic>,4<jats:italic>R</jats:italic>-APDC (10 nmol), results in robust neuroprotection of the nigrostriatal system, which translated into functional recovery as measured by improved forelimb use asymmetry and reduced (+)-amphetamine-induced rotation compared to vehicle treated animals. Interestingly, these beneficial effects were associated with a decrease in microglial markers in the SNc, which may suggest an antiinflammatory action of this drug.</jats:p>

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Ward RJ, Colivicchi MA, Allen R, Schol F, Lallemand F, de Witte P, Ballini C, Corte LD, Dexter Det al., 2009, Neuro-inflammation induced in the hippocampus of 'binge drinking' rats may be mediated by elevated extracellular glutamate content., J Neurochem, Vol: 111, Pages: 1119-1128

The neuropathological and immune changes induced in the brain by 'binge drinking' have been investigated in a rat model. Evidence of neuro-inflammation was identified in the 'binge drinking' rat model of alcohol abuse after 3 weeks of administration of 2 or 3 g/kg ethanol (EtOH), three times per day for two consecutive days, followed by 5 days of abstinence: Firstly, alveolar macrophages, isolated from these animals, showed significant increases in inducible nitric oxide synthase, as assayed by nitrite release, both before and after lipopolysaccaharide stimulation. Secondly, significant numbers of activated microglia were present in the dentate gyrus region of the hippocampus of the 'binge drinking' model, after major histocompatibility complex class II staining, by comparison with the control. Microdialysis studies in the ventral hippocampus identified a significant increase in the basal extracellular concentration of glutamate, in both the 2 and 3 g/kg administered 'binge drinking' rats. In contrast, no changes in the hippocampal extracellular concentrations, of GABA and taurine, or the dopamine and serotonin metabolites were observed under basal conditions. A further dose of EtOH induced a significant decrease in the concentrations of both 3,4-dihydroxyphenylacetic acid and 5-hydroxyindoleacetic acid, whereas glutamate, taurine and GABA levels were unaffected. There was no evidence that EtOH preference was initiated by the 'binge drinking' regimen. Our results suggest that the possible toxicity associated with 'binge drinking' maybe directed by the elevated glutamate levels, which in turn, activate phagocytic cells to release their inflammatory cytokines and chemokines, ultimately leading to neuro-inflammation.

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Marinova-Mutafchieva L, Sadeghian M, Broom L, Davis JB, Medhurst AD, Dexter DTet al., 2009, Relationship between microglial activation and dopaminergic neuronal loss in the substantia nigra: a time course study in a 6-hydroxydopamine model of Parkinson's disease, JOURNAL OF NEUROCHEMISTRY, Vol: 110, Pages: 966-975, ISSN: 0022-3042

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• Citations: 155

Durrenberger PF, Fernando S, Kashefi SN, Consortium BNE, Dexter DT, Reynolds Ret al., 2008, Microarray gene expression analysis of common pathogenetic mechanisms in neurodegenerative diseases, BrainNet Europe 2nd International Conference on Human Brain Tissue Research, Publisher: SPRINGER WIEN, Pages: 1730-1730, ISSN: 0300-9564

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Goldring K, McGuinness L, Vontell RT, Cairns HC, Pearce RK, Roncaroli F, Gentleman SM, Dexter DTet al., 2008, Clinicopathological classification of the first 100 cases donated to the UK PDS Tissue Bank at Imperial College, BrainNet Europe 2nd International Conference on Human Brain Tissue Research, Publisher: SPRINGER WIEN, Pages: 1724-1724, ISSN: 0300-9564

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McGuinness L, Vontell RT, Dexter DT, Pearce RK, Gentleman SM, Roncaroli F, Goldring Ket al., 2008, Optimisation of immunohistochemistry for visualising abnormal protein deposition in neurodegenerative disorders, BrainNet Europe 2nd International Conference on Human Brain Tissue Research, Publisher: SPRINGER WIEN, Pages: 1726-1726, ISSN: 0300-9564

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Durrenberger PF, Fernando S, Kashefi SN, Dexter DT, Reynolds Ret al., 2008, Gene expression profiling of grey matter lesions in secondary progressive multiple sclerosis, 13th Annual Meeting of the Amer-Comm-for-Treatment-and-Res-in-Multiple-Sclerosis/24th Congress of the European-Comm-for-Treatment-and-Res-in-Multiple-Sclerosis/5th Congress of the Latin-Amer-Comm-for-Treatment-and-Res-in-Multiple-Sclerosis, Publisher: SAGE PUBLICATIONS LTD, Pages: S270-S270, ISSN: 1352-4585

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Ward RJ, Lallemand F, de Witte P, Dexter DTet al., 2008, Neurochemical pathways involved in the protective effects of nicotine and ethanol in preventing the development of Parkinson's disease: Potential targets for the development of new therapeutic agents, PROGRESS IN NEUROBIOLOGY, Vol: 85, Pages: 135-147, ISSN: 0301-0082

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• Citations: 26

Crichton RR, Dexter DT, Ward RJ, 2008, Metal based neurodegenerative diseases - From molecular mechanisms to therapeutic strategies, COORDINATION CHEMISTRY REVIEWS, Vol: 252, Pages: 1189-1199, ISSN: 0010-8545

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• Citations: 227

Bell JE, Alafuzoff I, Al-Sarraj S, Arzberger T, Bogdanovic N, Budka H, Dexter DT, Falkai P, Ferrer I, Gelpi E, Gentleman SM, Giaccone G, Huitinga I, Ironside JW, Klioueva N, Kovacs GG, Meyronet D, Palkovits M, Parchi P, Patsouris E, Reynolds R, Riederer P, Roggendorf W, Seilhean D, Schmitt A, Schmitz P, Streichenberger N, Schwalber A, Kretzschmar Het al., 2008, Management of a twenty-first century brain bank: experience in the BrainNet Europe consortium, ACTA NEUROPATHOLOGICA, Vol: 115, Pages: 497-507, ISSN: 0001-6322

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• Citations: 86

Vernon AC, Croucher MJ, Dexter DT, 2008, Additive neuroprotection by metabotropic glutamate receptor subtype-selective ligands in a rat Parkinson's model, NEUROREPORT, Vol: 19, Pages: 475-478, ISSN: 0959-4965

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• Citations: 19

Vernon AC, Zbarsky V, Datla KP, Croucher MJ, Dexter DTet al., 2007, Subtype selective antagonism of substantia nigra pars compacta Group I metabotropic glutamate receptors protects the nigrostriatal system against 6-hydroxydopamine toxicity <i>in vivo</i>, JOURNAL OF NEUROCHEMISTRY, Vol: 103, Pages: 1075-1091, ISSN: 0022-3042

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• Citations: 49

Datla KP, Zbarsky V, Rai D, Parkar S, Osakabe N, Aruoma OI, Dexter DTet al., 2007, Short-term supplementation with plant extracts rich in flavonoids protect nigrostriatal Dopaminergic neurons in a rat model of Parkinson's Disease, JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION, Vol: 26, Pages: 341-349, ISSN: 0731-5724

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• Citations: 53

Slonimsky A, Hickey L, Christian L, Dexter DT, Pearce RKB, Graeber MB, Moran LBet al., 2007, Expression of gamma-synuclein in Parkinson's disease, 108th Annual Meeting of the British-Neuopathological-Society, Publisher: BLACKWELL PUBLISHING, Pages: 256-256, ISSN: 0305-1846

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Moran LB, Croisier E, Duke DC, Kalaitzakis ME, Roncaroli F, Deprez M, Dexter DT, Pearce RKB, Graeber MBet al., 2007, Analysis of alpha-synuclein, dopamine and parkin pathways in neuropathologically confirmed Parkinsonian nigra, ACTA NEUROPATHOLOGICA, Vol: 113, Pages: 253-263, ISSN: 0001-6322

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• Citations: 35

McArthur S, Murray HE, Dhankot A, Dexter DT, Gillies GEet al., 2007, Striatal susceptibility to a dopaminergic neurotoxin is independent of sex hormone effects on cell survival and DAT expression but is exacerbated by central aromatase inhibition, JOURNAL OF NEUROCHEMISTRY, Vol: 100, Pages: 678-692, ISSN: 0022-3042

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• Citations: 45

Vernon AC, Zbarsky V, Datla KP, Dexter DT, Croucher MJet al., 2007, Selective activation of group III metabotropic glutamate receptors by L-(+)-2-amino-4-phosphonobutryic acid protects the nigrostriatal system against 6-hydroxydopamine toxicity in vivo, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, Vol: 320, Pages: 397-409, ISSN: 0022-3565

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• Citations: 32

Moran LB, Duke DC, Croisier E, Slonimsky A, Kalaitzakis M, Deprez M, Dexter DT, Pearce RK, Graeber MBet al., 2006, Whole genome expression profiling reveals involvement of the cerebral cortex in Parkinson's disease, 16th International Congress of Neuropathology, Publisher: BLACKWELL PUBLISHING, Pages: S8-S8, ISSN: 1015-6305

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Duke DC, Moran LB, Kalaitzakis ME, Deprez M, Dexter DT, Pearce RKB, Graeber MBet al., 2006, Transcriptome analysis reveals link between proteasomal and mitochondrial pathways in Parkinson's disease, NEUROGENETICS, Vol: 7, Pages: 139-148, ISSN: 1364-6745

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• Citations: 73