Imperial College London
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ProfessorDanieleDini

Faculty of Engineering, Department of Mechanical Engineering

Professor in Tribology
 
 
 
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Contact

 

+44 (0)20 7594 7242d.dini Website

 
 
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Location

 

669City and Guilds BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Jamal:2022:10.3390/ijms23063139,
author = {Jamal, A and Yuan, T and Galvan, S and Castellano, A and Riva, M and Secoli, R and Falini, A and Bello, L and Rodriguez, y Baena F and Dini, D},
doi = {10.3390/ijms23063139},
journal = {International Journal of Molecular Sciences},
pages = {3139--3139},
title = {Insights into infusion-based targeted drug delivery in brain: perspectives, challenges and opportunities},
url = {http://dx.doi.org/10.3390/ijms23063139},
volume = {23},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Targeted drug delivery in the brain is instrumental in the treatment of lethal brain diseases, such as glioblastoma multiforme, the most aggressive primary central nervous system tumour in adults. Infusion-based drug delivery techniques, which directly administer to the tissue for local treatment, as in convection-enhanced delivery (CED), provide an important opportunity; however, poor understanding of the pressure-driven drug transport mechanisms in the brain has hindered its ultimate success in clinical applications. In this review, we focus on the biomechanical and biochemical aspects of infusion-based targeted drug delivery in the brain and look into the underlying molecular level mechanisms. We discuss recent advances and challenges in the complementary field of medical robotics and its use in targeted drug delivery in the brain. A critical overview of current research in these areas and their clinical implications is provided. This review delivers new ideas and perspectives for further studies of targeted drug delivery in the brain.
AU  - Jamal,A
AU  - Yuan,T
AU  - Galvan,S
AU  - Castellano,A
AU  - Riva,M
AU  - Secoli,R
AU  - Falini,A
AU  - Bello,L
AU  - Rodriguez,y Baena F
AU  - Dini,D
DO  - 10.3390/ijms23063139
EP  - 3139
PY  - 2022///
SN  - 1422-0067
SP  - 3139
TI  - Insights into infusion-based targeted drug delivery in brain: perspectives, challenges and opportunities
T2  - International Journal of Molecular Sciences
UR  - http://dx.doi.org/10.3390/ijms23063139
UR  - https://www.mdpi.com/1422-0067/23/6/3139
UR  - http://hdl.handle.net/10044/1/95828
VL  - 23
ER  -
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