Publications
138 results found
Crane JS, Jackson MJ, Bicknell CD, et al., 2003, In-vivo geometric features of distal vein graft anastomoses: magnetic resonance surface reconstruction in different graft techniques, British Journal of Surgery, Vol: 90, Pages: 16-16, ISSN: 0007-1323
Smith FT, Ovenden NC, Franke PT, et al., 2003, What happens to pressure when a flow enters a side branch?, JOURNAL OF FLUID MECHANICS, Vol: 479, Pages: 231-258, ISSN: 0022-1120
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- Citations: 27
Doorly DJ, Franke PT, Papaharilaou Y, et al., 2003, Measuring and modelling the interaction between the arterial wall and blood flow transport, Internal Medicine Clinical and Laboratory, Vol: 11, Pages: 3-13, ISSN: 1590-9271
This work describes computer simulation and experimental techniques applied in combination to investigate the geometry and haemodynamics of arteries, with particular reference to arterial graft design. The geometry of grafts is determined from in-vivo measurements and from resin casts by magnetic resonance imaging (MRI). Computational fluid dynamics (CFD) simulations are used to investigate the relation between arterial geometry, wall shear stress and particle transport. The use of stereo-lithographic (STL) techniques to supplement conventional MRI in-vivo, and to help to bridge the gap with computational modelling by providing realistic models for experimental investigations is reviewed. Methods to investigate the integrated fluid shear loading of particles, the transport of vasoactive species such as ADP, the residence time and the role of geometry in flow mixing are described. Finally the combined application of CFD, MRI and STL to study the flow in grafts and the effects of disease progression is discussed.
Sherwin SJ, Doorly DJ, 2003, Flow dynamics within model distal arterial bypass grafts, Advances in Fluid Mechanics, Vol: 34, Pages: 327-374, ISSN: 1353-808X
Doorly DJ, Papaharilaou Y, Franke PT, et al., 2002, Measuring and modelling the interaction between the arterial wall and blood flow transport, 4th International Congress on Progress in Bioengineering and the Vascular Endothelium/7th International Congress on Advances in Management of Malignancies, Publisher: EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, Pages: 345-345, ISSN: 0753-3322
Papaharilaou Y, Doorly DJ, Sherwin SJ, 2002, The influence of out-of-plane geometry on pulsatile flow within a distal end-to-side anastomosis, JOURNAL OF BIOMECHANICS, Vol: 35, Pages: 1225-1239, ISSN: 0021-9290
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- Citations: 65
Jackson MJ, Papaharilaou Y, Giordana S, et al., 2002, <i>In vivo</i> geometric features of femoral bypass distal anastomoses, BRITISH JOURNAL OF SURGERY, Vol: 89, Pages: 56-56, ISSN: 0007-1323
Doorly DJ, Sherwin SJ, Franke PT, et al., 2002, Vortical flow structure identification and flow transport in arteries, Computer Methods in Biomechanics and Biomedical Engineering, Vol: 5, Pages: 261-273, ISSN: 1025-5842
Papaharilaou Y, Doorly DJ, Sherwin SJ, et al., 2002, Combined MR imaging and numerical simulation of flow in realistic arterial bypass graft models, BIORHEOLOGY, Vol: 39, Pages: 525-531, ISSN: 0006-355X
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- Citations: 17
Doorly DJ, Sherwin SJ, Franke PT, et al., 2002, Vortical flow structure identification and flow transport in arteries, Computer Methods in Biomechanics and Biomedical Engineering, Vol: 5, Pages: 261-273, ISSN: 1025-5842
Sherwin SJ, Doorly DJ, Franke P, et al., 2002, Unsteady near wall residence times and shear exposure in model distal arterial bypass grafts, BIORHEOLOGY, Vol: 39, Pages: 365-371, ISSN: 0006-355X
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- Citations: 4
Giordana S, Peiro J, Sherwin S, et al., 2002, Classification of peripheral distal by-pass geometries obtained via reconstruction from MRI, ESAIM: Proceedings, Vol: 12, Pages: 55-60
Jackson MJ, Papaharilaou Y, Giordana S, et al., 2002, Vascular 10, British Journal of Surgery, Vol: 89, Pages: 56-56, ISSN: 0007-1323
Sherwin SJ, Doorly DJ, 2002, Flow dynamics within model distal arterial bypass grafts, Vascular Grafts: experiment and modelling (Advances in fluid mechanics series), Editors: Tura, Rahman, Satish, Tura, Rahman, Satish, Publisher: WIT Press, Pages: 327-374, ISBN: 9781853129001
Papaharilaou Y, Doorly DJ, Sherwin SJ, 2001, Assessing the accuracy of two-dimensional phase-contrast MRI measurements of complex unsteady flows, JOURNAL OF MAGNETIC RESONANCE IMAGING, Vol: 14, Pages: 714-723, ISSN: 1053-1807
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- Citations: 19
Giordana S, Griffith C, Peiro J, et al., 2001, Geometry reconstruction and mesh generation using variational implicit surfaces, 5th international symposium on computer methods in biomechanics and biomedical engineering, Rome, 31 October - 3 November 2001
Papaharilaou Y, Doorly DJ, Sherwin SJ, et al., 2001, Combined MRI and computational fluid dynamics detailed investigation of flow in a realistic coronary artery bypass graft model, Proceedings of the 9th ISMRM-ESMRMB, Glasgow, 2001
Atherton MA, Doorly DJ, Collins MW, et al., 2000, A new approach to planning in vitro and in vivo experiments for cardiovascular stents. (2) Planning of experiments, Internal Medicine Clinical and Laboratory, Vol: 8, Pages: 31-36, ISSN: 1590-9271
Within our overall project to improve the design of stents in terms of reduced rates of re-stenosis, there are three main methods, namely computer simulation and in vitro and in vivo experiments. These methods are closely integrated using contemporary design procedures described below, especially to accomodate patient-to-patient variation. Clinical experience shows that a small variation has considerable effects on flow characteristics of stents and in engineering terms may be described as a «geometric risk factor». The Robust Engineering Design procedure readily incorporates this factor which may thus become a component feature in our experimental planning. We envisage that this approach could be applied to other invasive implants with a view to enhancing their quality.
Atherton MA, Doorly DJ, Collins MW, 2000, A new approach to planning in vitro and in vivo experiment for cardiovascular stents. (1) Fundamentals of design procedures, Internal Medicine Clinical and Laboratory, Vol: 8, Pages: 25-30, ISSN: 1590-9271
While the use of cardiovascular stents is internationally widespread re-stenosis remains a common problem. There are a number of different design, and this project seeks for design improvements leading to a reduction in restenosis rates. The haemodynamics of the stent as used in patients is viewed as one of the major concerns, and the authors have already applied Computational Fluid Dynamics in investigating this. In this more comprehensive study, however, the novel approach of applying two formal engineering design procedures is used, namely Genetic Algorithms (GA) and Robust Engineering Design (RED). In this paper, the two procedures are explained and compared in the context of their application to the design of stents.
Caro CG, Watkins N, Doorly DJ, et al., 2000, Steady flow in a tube with helical internal ridging/channelling, JOURNAL OF PHYSIOLOGY-LONDON, Vol: 525, Pages: 3P-4P, ISSN: 0022-3751
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- Citations: 2
Liu CH, Doorly DJ, 2000, Vortex particle-in-cell method for three-dimensional viscous unbounded flow computations, International Journal for Numerical Methods in Fluids, Vol: 32, Pages: 23-42, ISSN: 0271-2091
Liu CH, Doorly DJ, 2000, Vortex particle-in-cell method for three-dimensional viscous unbounded flow computations, INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN FLUIDS, Vol: 32, Pages: 29-50, ISSN: 0271-2091
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- Citations: 9
Sherwin SJ, Shah O, Doorly DJ, et al., 2000, The influence of out-of-plane geometry on the flow within a distal end-to-side anastomosis, Journal of Biomechanical Engineering-Transactions of the Asme, Vol: 122, Pages: 86-95
Sherwin SJ, Piero J, Shah O, et al., 2000, Computational Haemodynamics: Geometry and Non-Newtonian Modelling using Spectral/hp Element Methods, Computing and Visualization in Science, Vol: 3, Pages: 77-83
Doorly DJ, Spooner S, Peiro J, 2000, Supervised evolutionary methods in aerodynamic design optimisation, Real-World Applications of Evolutionary Computing, Proceedings, Vol: 1803, Pages: 357-366, ISSN: 0302-9743
Doorly DJ, Peiró J, Spooner S, 1999, Design optimisation using distributed evolutionary methods
This paper describes evolutionary search procedures and their application to some aeronautical optimisation problems. Genetic algorithms (GAs) have now been applied to many different fields, and have proven to be relatively robust means to search for optimal solutions. The focus in this work is on techniques to improve the efficiency of the simple GA, and on applications of GAs to problems in aeronautical design optimisation. The distributed genetic algorithm (DGA) is outlined, which has previously been found to perform substantially better than the conventional single population GA in many problems. As well as offering higher search efficiency, the DGA also offers further computational efficiency through parallel implementation. In the DGA, the population of trial solutions is split into semi-isolated subpopulations or ’denies’. The use of an agent to supervise the operation of the DGA, and some forms in which it may be implemented are outlined. Evolutionary learning techniques and competitive agent strategies are also discussed. Applications to problems of airfoil optimisation, and to the design of adaptive surface airfoils are considered.
Liu CH, Doorly DJ, 1999, Velocity-vorticity formulation with vortex particle-in-cell method for incompressible viscous flow simulation, part II: Application to vortex wall interactions, NUMERICAL HEAT TRANSFER PART B-FUNDAMENTALS, Vol: 35, Pages: 277-294, ISSN: 1040-7790
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- Citations: 5
Liu CH, Doorly DJ, 1999, Velocity-vorticity formulation with vortex particle-in-cell method for incompressible viscous flow simulation, part I: Formulation and validation, NUMERICAL HEAT TRANSFER PART B-FUNDAMENTALS, Vol: 35, Pages: 251-275, ISSN: 1040-7790
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- Citations: 9
Doorly DJ, 1999, Modelling of flow transport in arteries, Cardiovascular Flow Modelling and Measurement with Application to Clinical Medicine, Vol: 70, Pages: 67-81
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