MD, PhD, MRCPsych, Clinical Senior Lecturer in General Psychiatry in Centres for Neuropsychopharmacology and Psychedelic Research at Imperial and Consultant Psychiatrist at St Charles Hospital, CNWL Mental Health NHS Foundation Trust.
David conducts psychopharmacological research, using brain-imaging techniques such as PET and MRI. He was trained in PET imaging at Columbia University in New York and later undertook a PhD at University Hospital Rigshospitalet in Copenhagen. Since 2009 he has been involved in post-doc imaging research into the neurobiology of addictions and major depression at Imperial. David has been investigating dopaminergic neurotransmission with measurements of the dopamine D3 receptor in alcohol addiction, studies of opioid neurotransmission in pathological gambling, and functional imaging studies looking at the role of dopamine D3 and mu-opiate receptors in cocaine, alcohol, and heroin addiction.
Currently, he runs lab-based multi-modal brain imaging studies [often using pharmacological challenges] focusing on serotonin/dopamine/opiate neurotransmission as well as larger-scale prospective, naturalistic studies with online assessments and/or field-based data collection. Specifically, in the Centre for Psychedelic Research [where David is Clinical Director], studies are undertaken together with Prof Nutt and Dr Carhart-Harris, investigating brain mechanisms and therapeutic potential of MDMA and classic psychedelics.
et al., 2020, Therapeutic effects of classic serotonergic psychedelics: A systematic review of modern-era clinical studies, Acta Psychiatrica Scandinavica, Vol:143, ISSN:0001-690X, Pages:101-118
et al., 2020, Brain serotonin 2A receptor binding predicts subjective temporal and mystical effects of psilocybin in healthy humans, Journal of Psychopharmacology, ISSN:0269-8811
et al., 2020, Acute effects of MDMA on trust, cooperative behaviour and empathy: A double-blind, placebo-controlled experiment, Journal of Psychopharmacology, ISSN:0269-8811
Nutt D, Erritzoe D, Carhart-Harris R, 2020, Psychedelic Psychiatry's Brave New World, Cell, Vol:181, ISSN:0092-8674, Pages:24-28
et al., 2020, Serotonin release measured in the human brain: A PET study with [11C]CIMBI-36 and d-amphetamine challenge, Neuropsychopharmacology, Vol:45, ISSN:0893-133X, Pages:804-810