Imperial College London
Alternate

DrDavidErritzoe

Faculty of Medicine, Department of Brain Sciences

Clinical Senior Lecturer in Psychiatry
 
 
 
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d.erritzoe

 
 
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Location

 

Centres for Neuropsychopharmacology and Psychedelic ResearchCommonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Erritzoe:2020:10.1038/s41386-019-0567-5,
author = {Erritzoe, D and Ashok, AH and Searle, GE and Colasanti, A and Turton, S and Lewis, Y and Huiban, M and Moz, S and Passchier, J and Saleem, A and Beaver, J and Lingford-Hughes, A and Nutt, DJ and Howes, O and Gunn, RN and Knudsen, GM and Rabiner, E},
doi = {10.1038/s41386-019-0567-5},
journal = {Neuropsychopharmacology},
pages = {804--810},
title = {Serotonin release measured in the human brain: A PET study with [11C]CIMBI-36 and d-amphetamine challenge},
url = {http://dx.doi.org/10.1038/s41386-019-0567-5},
volume = {45},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Positron emission tomography (PET) enables non-invasive estimation of neurotransmitter fluctuations in the living human brain. While these methods have been applied to dopamine and some other transmitters, estimation of 5-hydroxytryptamine (5-HT; Serotonin) release has proved to be challenging. Here we demonstrate the utility of the novel 5-HT2A receptor agonist radioligand, [11C]CIMBI-36, and a d-amphetamine challenge to evaluate synaptic 5-HT changes in the living human brain.  Seventeen healthy male volunteers received [11C]CIMBI-36 PET scans before and 3 hours after an oral dose of d-amphetamine (0.5 mg/kg). Dynamic PET data were acquired over 90 minutes, and the total volume of distribution (VT) in the frontal cortex and the cerebellum derived from a kinetic analysis using MA1. The frontal cortex binding potential (BPNDfrontal) was calculated as (VTfrontal/VTcerebellum)-1.  BPNDfrontal  = 1- (BPNDfrontalpost-dose/ BPNDfrontalbaseline) was used as an index of 5-HT release. Statistical inference was tested by means of a paired Students t-test evaluating a reduction in post-amphetamine [11C]CIMBI-36 BPNDfrontal .Following d-amphetamine administration, [11C]CIMBI-36 BPNDfrontal was reduced by 14 ± 13 % (p = 0.002). Similar effects were observed in other cortical regions examined in an exploratory analysis.[11C]CIMBI-36 binding is sensitive to synaptic serotonin release in the human brain, and when combined with a d-amphetamine challenge, the evaluation of the human brain serotonin system in neuropsychiatric disorders, such as major depression and Parkinson’s disease is enabled.
AU  - Erritzoe,D
AU  - Ashok,AH
AU  - Searle,GE
AU  - Colasanti,A
AU  - Turton,S
AU  - Lewis,Y
AU  - Huiban,M
AU  - Moz,S
AU  - Passchier,J
AU  - Saleem,A
AU  - Beaver,J
AU  - Lingford-Hughes,A
AU  - Nutt,DJ
AU  - Howes,O
AU  - Gunn,RN
AU  - Knudsen,GM
AU  - Rabiner,E
DO  - 10.1038/s41386-019-0567-5
EP  - 810
PY  - 2020///
SN  - 0893-133X
SP  - 804
TI  - Serotonin release measured in the human brain: A PET study with [11C]CIMBI-36 and d-amphetamine challenge
T2  - Neuropsychopharmacology
UR  - http://dx.doi.org/10.1038/s41386-019-0567-5
UR  - http://hdl.handle.net/10044/1/74520
VL  - 45
ER  -
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