Imperial College London
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ProfessorDarioFarina

Faculty of Engineering, Department of Bioengineering

Chair in Neurorehabilitation Engineering
 
 
 
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Contact

 

+44 (0)20 7594 1387d.farina Website

 
 
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Location

 

RSM 4.15Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Mrachacz-Kersting:2019:10.1002/ana.25375,
author = {Mrachacz-Kersting, N and Stevenson, AJT and Jørgensen, HRM and Severinsen, KE and Aliakbaryhosseinabadi, S and Jiang, N and Farina, D},
doi = {10.1002/ana.25375},
journal = {Annals of Neurology},
pages = {84--95},
title = {Brain state-dependent stimulation boosts functional recovery following stroke},
url = {http://dx.doi.org/10.1002/ana.25375},
volume = {85},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - OBJECTIVE: Adjuvant protocols devised to enhance motor recovery in subacute stroke patients have failed to show benefits with respect to classic therapeutic interventions. Here, we evaluate the efficacy of a novel brain state-dependent intervention based on known mechanisms of memory and learning that is integrated as part of the weekly rehabilitation program in subacute stroke patients. METHODS: Twenty-four hospitalized subacute stroke patients were randomly assigned to 2 intervention groups: (1) the associative group received 30 pairings of a peripheral electrical nerve stimulus (ES) such that the generated afferent volley arrived precisely during the most active phase of the motor cortex as patients attempted to perform a movement; and (2) in the control group, the ES intensity was too low to generate a stimulation of the nerve. Functional (including the lower extremity Fugl-Meyer assessment [LE-FM; primary outcome measure]) and neurophysiological (changes in motor evoked potentials [MEPs]) assessments were performed prior to and following the intervention period. RESULTS: The associative group significantly improved functional recovery with respect to the control group (median [interquartile range] LE-FM improvement = 6.5 [3.5-8.25] and 3 [0.75-3], respectively; p = 0.029). Significant increases in MEP amplitude were seen following all sessions in the associative group only (p ≤ 0.006). INTERPRETATION: This is the first evidence of a clinical effect of a neuromodulatory intervention in the subacute phase of stroke. This was evident with relatively few repetitions in comparison to available techniques, making it a clinically viable approach. The results indicate the potential of the proposed neuromodulation system in daily clinical routine for stroke rehabilitation.
AU  - Mrachacz-Kersting,N
AU  - Stevenson,AJT
AU  - Jørgensen,HRM
AU  - Severinsen,KE
AU  - Aliakbaryhosseinabadi,S
AU  - Jiang,N
AU  - Farina,D
DO  - 10.1002/ana.25375
EP  - 95
PY  - 2019///
SN  - 0364-5134
SP  - 84
TI  - Brain state-dependent stimulation boosts functional recovery following stroke
T2  - Annals of Neurology
UR  - http://dx.doi.org/10.1002/ana.25375
UR  - https://www.ncbi.nlm.nih.gov/pubmed/30408227
UR  - https://onlinelibrary.wiley.com/doi/abs/10.1002/ana.25375
VL  - 85
ER  -
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