Imperial College London
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ProfessorDarioFarina

Faculty of Engineering, Department of Bioengineering

Chair in Neurorehabilitation Engineering
 
 
 
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Contact

 

+44 (0)20 7594 1387d.farina Website

 
 
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Location

 

RSM 4.15Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Thompson:2019:10.1152/japplphysiol.00110.2019,
author = {Thompson, CK and Johnson, MD and Negro, F and Mcpherson, LM and Farina, D and Heckman, CJ},
doi = {10.1152/japplphysiol.00110.2019},
journal = {J Appl Physiol (1985)},
pages = {1034--1041},
title = {Exogenous neuromodulation of spinal neurons induces beta-band coherence during self-sustained discharge of hind limb motor unit populations.},
url = {http://dx.doi.org/10.1152/japplphysiol.00110.2019},
volume = {127},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The spontaneous or self-sustained discharge of spinal motoneurons can be observed in both animals and humans. Although the origins of this self-sustained discharge are not fully known, it can be generated by activation of persistent inward currents intrinsic to the motoneuron. If self-sustained discharge is generated exclusively through this intrinsic mechanism, the discharge of individual motor units will be relatively independent of one another. Alternatively, if increased activation of premotor circuits underlies this prolonged discharge of spinal motoneurons, we would expect correlated activity among motoneurons. Our aim is to assess potential synaptic drive by quantifying coherence during self-sustained discharge of spinal motoneurons. Electromyographic activity was collected from 20 decerebrate animals using a 64-channel electrode grid placed on the isolated soleus muscle before and following intrathecal administration of methoxamine, a selective α1-noradrenergic agonist. Sustained muscle activity was recorded and decomposed into the discharge times of ~10-30 concurrently active individual motor units. Consistent with previous reports, the self-sustained discharge of motor units occurred at low mean discharge rates with low-interspike variability. Before methoxamine administration, significant low-frequency coherence (<2 Hz) was observed, while minimal coherence was observed within higher frequency bands. Following intrathecal administration of methoxamine, increases in motor unit discharge rates and strong coherence in both the low-frequency and 15- to 30-Hz beta bands were observed. These data demonstrate beta-band coherence among motor units can be observed through noncortical mechanisms and that neuromodulation of spinal/brainstem neurons greatly influences coherent discharge within spinal motor pools.NEW & NOTEWORTHY The correlated discharge of spinal motoneurons is often used to describe the input to the motor pool. We demonstrate spinal/bra
AU  - Thompson,CK
AU  - Johnson,MD
AU  - Negro,F
AU  - Mcpherson,LM
AU  - Farina,D
AU  - Heckman,CJ
DO  - 10.1152/japplphysiol.00110.2019
EP  - 1041
PY  - 2019///
SP  - 1034
TI  - Exogenous neuromodulation of spinal neurons induces beta-band coherence during self-sustained discharge of hind limb motor unit populations.
T2  - J Appl Physiol (1985)
UR  - http://dx.doi.org/10.1152/japplphysiol.00110.2019
UR  - https://www.ncbi.nlm.nih.gov/pubmed/31318619
VL  - 127
ER  -
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