Imperial College London
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ProfessorDarioFarina

Faculty of Engineering, Department of Bioengineering

Chair in Neurorehabilitation Engineering
 
 
 
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Contact

 

+44 (0)20 7594 1387d.farina Website

 
 
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Location

 

RSM 4.15Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Tereshenko:2023:10.1016/j.jare.2022.04.009,
author = {Tereshenko, V and Maierhofer, U and Dotzauer, DC and Laengle, G and Schmoll, M and Festin, C and Luft, M and Carrero, Rojas G and Politikou, O and Hruby, LA and Klein, HJ and Eisenhardt, SU and Farina, D and Blumer, R and Bergmeister, KD and Aszmann, OC},
doi = {10.1016/j.jare.2022.04.009},
journal = {J Adv Res},
pages = {135--147},
title = {Newly identified axon types of the facial nerve unveil supplemental neural pathways in the innervation of the face.},
url = {http://dx.doi.org/10.1016/j.jare.2022.04.009},
volume = {44},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - INTRODUCTION: Neuromuscular control of the facial expressions is provided exclusively via the facial nerve. Facial muscles are amongst the most finely tuned effectors in the human motor system, which coordinate facial expressions. In lower vertebrates, the extracranial facial nerve is a mixed nerve, while in mammals it is believed to be a pure motor nerve. However, this established notion does not agree with several clinical signs in health and disease. OBJECTIVES: To elucidate the facial nerve contribution to the facial muscles by investigating axonal composition of the human facial nerve. To reveal new innervation pathways of other axon types of the motor facial nerve. METHODS: Different axon types were distinguished using specific molecular markers (NF, ChAT, CGRP and TH). To elucidate the functional role of axon types of the facial nerve, we used selective elimination of other neuronal support from the trigeminal nerve. We used retrograde neuronal tracing, three-dimensional imaging of the facial muscles, and high-fidelity neurophysiological tests in animal model. RESULTS: The human facial nerve revealed a mixed population of only 85% motor axons. Rodent samples revealed a fiber composition of motor, afferents and, surprisingly, sympathetic axons. We confirmed the axon types by tracing the originating neurons in the CNS. The sympathetic fibers of the facial nerve terminated in facial muscles suggesting autonomic innervation. The afferent fibers originated in the facial skin, confirming the afferent signal conduction via the facial nerve. CONCLUSION: These findings reveal new innervation pathways via the facial nerve, support the sympathetic etiology of hemifacial spasm and elucidate clinical phenomena in facial nerve regeneration.
AU  - Tereshenko,V
AU  - Maierhofer,U
AU  - Dotzauer,DC
AU  - Laengle,G
AU  - Schmoll,M
AU  - Festin,C
AU  - Luft,M
AU  - Carrero,Rojas G
AU  - Politikou,O
AU  - Hruby,LA
AU  - Klein,HJ
AU  - Eisenhardt,SU
AU  - Farina,D
AU  - Blumer,R
AU  - Bergmeister,KD
AU  - Aszmann,OC
DO  - 10.1016/j.jare.2022.04.009
EP  - 147
PY  - 2023///
SP  - 135
TI  - Newly identified axon types of the facial nerve unveil supplemental neural pathways in the innervation of the face.
T2  - J Adv Res
UR  - http://dx.doi.org/10.1016/j.jare.2022.04.009
UR  - https://www.ncbi.nlm.nih.gov/pubmed/36725185
VL  - 44
ER  -
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