Imperial College London
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ProfessorDarioFarina

Faculty of Engineering, Department of Bioengineering

Chair in Neurorehabilitation Engineering
 
 
 
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Contact

 

+44 (0)20 7594 1387d.farina Website

 
 
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Location

 

RSM 4.15Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Khan:2022:10.1371/journal.pbio.3001923,
author = {Khan, MN and Cherukuri, P and Negro, F and Rajput, A and Fabrowski, P and Bansal, V and Lancelin, C and Lee, T-I and Bian, Y and Mayer, WP and Akay, T and Müller, D and Bonn, S and Farina, D and Marquardt, T},
doi = {10.1371/journal.pbio.3001923},
journal = {PLoS Biol},
title = {ERR2 and ERR3 promote the development of gamma motor neuron functional properties required for proprioceptive movement control.},
url = {http://dx.doi.org/10.1371/journal.pbio.3001923},
volume = {20},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The ability of terrestrial vertebrates to effectively move on land is integrally linked to the diversification of motor neurons into types that generate muscle force (alpha motor neurons) and types that modulate muscle proprioception, a task that in mammals is chiefly mediated by gamma motor neurons. The diversification of motor neurons into alpha and gamma types and their respective contributions to movement control have been firmly established in the past 7 decades, while recent studies identified gene expression signatures linked to both motor neuron types. However, the mechanisms that promote the specification of gamma motor neurons and/or their unique properties remained unaddressed. Here, we found that upon selective loss of the orphan nuclear receptors ERR2 and ERR3 (also known as ERRβ, ERRγ or NR3B2, NR3B3, respectively) in motor neurons in mice, morphologically distinguishable gamma motor neurons are generated but do not acquire characteristic functional properties necessary for regulating muscle proprioception, thus disrupting gait and precision movements. Complementary gain-of-function experiments in chick suggest that ERR2 and ERR3 could operate via transcriptional activation of neural activity modulators to promote a gamma motor neuron biophysical signature of low firing thresholds and high firing rates. Our work identifies a mechanism specifying gamma motor neuron functional properties essential for the regulation of proprioceptive movement control.
AU  - Khan,MN
AU  - Cherukuri,P
AU  - Negro,F
AU  - Rajput,A
AU  - Fabrowski,P
AU  - Bansal,V
AU  - Lancelin,C
AU  - Lee,T-I
AU  - Bian,Y
AU  - Mayer,WP
AU  - Akay,T
AU  - Müller,D
AU  - Bonn,S
AU  - Farina,D
AU  - Marquardt,T
DO  - 10.1371/journal.pbio.3001923
PY  - 2022///
TI  - ERR2 and ERR3 promote the development of gamma motor neuron functional properties required for proprioceptive movement control.
T2  - PLoS Biol
UR  - http://dx.doi.org/10.1371/journal.pbio.3001923
UR  - https://www.ncbi.nlm.nih.gov/pubmed/36542664
VL  - 20
ER  -
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