Imperial College London
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DrDanielaFecht

Faculty of Medicine, School of Public Health

Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 3314d.fecht

 
 
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Location

 

529Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Wolf:2021:10.1016/S2542-5196(21)00195-9,
author = {Wolf, K and Hoffmann, B and Andersen, ZJ and Atkinson, RW and Bauwelinck, M and Bellander, T and Brandt, J and Brunekreef, B and Cesaroni, G and Chen, J and de, Faire U and de, Hoogh K and Fecht, D and Forastiere, F and Gulliver, J and Hertel, O and Hvidtfeldt, UA and Janssen, NAH and Jørgensen, JT and Katsouyanni, K and Ketzel, M and Klompmaker, JO and Lager, A and Liu, S and MacDonald, CJ and Magnusson, PKE and Mehta, AJ and Nagel, G and Oftedal, B and Pedersen, NL and Pershagen, G and Raaschou-Nielsen, O and Renzi, M and Rizzuto, D and Rodopoulou, S and Samoli, E and van, der Schouw YT and Schramm, S and Schwarze, P and Sigsgaard, T and Sørensen, M and Stafoggia, M and Strak, M and Tjønneland, A and Verschuren, WMM and Vienneau, D and Weinmayr, G and Hoek, G and Peters, A and Ljungman, PLS},
doi = {10.1016/S2542-5196(21)00195-9},
journal = {The Lancet Planetary Health},
pages = {e620--e632},
title = {Long-term exposure to low-level ambient air pollution and incidence of stroke and coronary heart disease: a pooled analysis of six European cohorts within the ELAPSE project},
url = {http://dx.doi.org/10.1016/S2542-5196(21)00195-9},
volume = {5},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: Long-term exposure to outdoor air pollution increases the risk of cardiovascular disease, but evidence is unclear on the health effects of exposure to pollutant concentrations lower than current EU and US standards and WHO guideline limits. Within the multicentre study Effects of Low-Level Air Pollution: A Study in Europe (ELAPSE), we investigated the associations of long-term exposures to fine particulate matter (PM2·5), nitrogen dioxide (NO2), black carbon, and warm-season ozone (O3) with the incidence of stroke and acute coronary heart disease. METHODS: We did a pooled analysis of individual data from six population-based cohort studies within ELAPSE, from Sweden, Denmark, the Netherlands, and Germany (recruited 1992-2004), and harmonised individual and area-level variables between cohorts. Participants (all adults) were followed up until migration from the study area, death, or incident stroke or coronary heart disease, or end of follow-up (2011-15). Mean 2010 air pollution concentrations from centrally developed European-wide land use regression models were assigned to participants' baseline residential addresses. We used Cox proportional hazards models with increasing levels of covariate adjustment to investigate the association of air pollution exposure with incidence of stroke and coronary heart disease. We assessed the shape of the concentration-response function and did subset analyses of participants living at pollutant concentrations lower than predefined values. FINDINGS: From the pooled ELAPSE cohorts, data on 137148 participants were analysed in our fully adjusted model. During a median follow-up of 17·2 years (IQR 13·8-19·5), we observed 6950 incident events of stroke and 10071 incident events of coronary heart disease. Incidence of stroke was associated with PM2·5 (hazard ratio 1·10 [95% CI 1·01-1·21] per 5 μg/m3 increase), NO2 (1·08 [1·04-1·12] per 10 μ
AU  - Wolf,K
AU  - Hoffmann,B
AU  - Andersen,ZJ
AU  - Atkinson,RW
AU  - Bauwelinck,M
AU  - Bellander,T
AU  - Brandt,J
AU  - Brunekreef,B
AU  - Cesaroni,G
AU  - Chen,J
AU  - de,Faire U
AU  - de,Hoogh K
AU  - Fecht,D
AU  - Forastiere,F
AU  - Gulliver,J
AU  - Hertel,O
AU  - Hvidtfeldt,UA
AU  - Janssen,NAH
AU  - Jørgensen,JT
AU  - Katsouyanni,K
AU  - Ketzel,M
AU  - Klompmaker,JO
AU  - Lager,A
AU  - Liu,S
AU  - MacDonald,CJ
AU  - Magnusson,PKE
AU  - Mehta,AJ
AU  - Nagel,G
AU  - Oftedal,B
AU  - Pedersen,NL
AU  - Pershagen,G
AU  - Raaschou-Nielsen,O
AU  - Renzi,M
AU  - Rizzuto,D
AU  - Rodopoulou,S
AU  - Samoli,E
AU  - van,der Schouw YT
AU  - Schramm,S
AU  - Schwarze,P
AU  - Sigsgaard,T
AU  - Sørensen,M
AU  - Stafoggia,M
AU  - Strak,M
AU  - Tjønneland,A
AU  - Verschuren,WMM
AU  - Vienneau,D
AU  - Weinmayr,G
AU  - Hoek,G
AU  - Peters,A
AU  - Ljungman,PLS
DO  - 10.1016/S2542-5196(21)00195-9
EP  - 632
PY  - 2021///
SN  - 2542-5196
SP  - 620
TI  - Long-term exposure to low-level ambient air pollution and incidence of stroke and coronary heart disease: a pooled analysis of six European cohorts within the ELAPSE project
T2  - The Lancet Planetary Health
UR  - http://dx.doi.org/10.1016/S2542-5196(21)00195-9
UR  - https://www.ncbi.nlm.nih.gov/pubmed/34508683
UR  - http://hdl.handle.net/10044/1/91596
VL  - 5
ER  -
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