Imperial College London
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DrDanielaFecht

Faculty of Medicine, School of Public Health

Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 3314d.fecht

 
 
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Location

 

1119Sir Michael Uren HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Stafoggia:2022:10.1016/S2542-5196(21)00277-1,
author = {Stafoggia, M and Oftedal, B and Chen, J and Rodopoulou, S and Renzi, M and Atkinson, RW and Bauwelinck, M and Klompmaker, JO and Mehta, A and Vienneau, D and Andersen, ZJ and Bellander, T and Brandt, J and Cesaroni, G and de, Hoogh K and Fecht, D and Gulliver, J and Hertel, O and Hoffmann, B and Hvidtfeldt, UA and Jöckel, K-H and Jørgensen, JT and Katsouyanni, K and Ketzel, M and Kristoffersen, DT and Lager, A and Leander, K and Liu, S and Ljungman, PLS and Nagel, G and Pershagen, G and Peters, A and Raaschou-Nielsen, O and Rizzuto, D and Schramm, S and Schwarze, PE and Severi, G and Sigsgaard, T and Strak, M and van, der Schouw YT and Verschuren, M and Weinmayr, G and Wolf, K and Zitt, E and Samoli, E and Forastiere, F and Brunekreef, B and Hoek, G and Janssen, NAH},
doi = {10.1016/S2542-5196(21)00277-1},
journal = {The Lancet Planetary Health},
pages = {e9--e18},
title = {Long-term exposure to low ambient air pollution concentrations and mortality among 28 million people: results from seven large European cohorts within the ELAPSE project},
url = {http://dx.doi.org/10.1016/S2542-5196(21)00277-1},
volume = {6},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: Long-term exposure to ambient air pollution has been associated with premature mortality, but associations at concentrations lower than current annual limit values are uncertain. We analysed associations between low-level air pollution and mortality within the multicentre study Effects of Low-Level Air Pollution: A Study in Europe (ELAPSE). METHODS: In this multicentre longitudinal study, we analysed seven population-based cohorts of adults (age ≥30 years) within ELAPSE, from Belgium, Denmark, England, the Netherlands, Norway, Rome (Italy), and Switzerland (enrolled in 2000-11; follow-up until 2011-17). Mortality registries were used to extract the underlying cause of death for deceased individuals. Annual average concentrations of fine particulate matter (PM2·5), nitrogen dioxide (NO2), black carbon, and tropospheric warm-season ozone (O3) from Europe-wide land use regression models at 100 m spatial resolution were assigned to baseline residential addresses. We applied cohort-specific Cox proportional hazard models with adjustment for area-level and individual-level covariates to evaluate associations with non-accidental mortality, as the main outcome, and with cardiovascular, non-malignant respiratory, and lung cancer mortality. Subset analyses of participants living at low pollutant concentrations (as per predefined values) and natural splines were used to investigate the concentration-response function. Cohort-specific effect estimates were pooled in a random-effects meta-analysis. FINDINGS: We analysed 28153138 participants contributing 257859621 person-years of observation, during which 3593741 deaths from non-accidental causes occurred. We found significant positive associations between non-accidental mortality and PM2·5, NO2, and black carbon, with a hazard ratio (HR) of 1·053 (95% CI 1·021-1·085) per 5 μg/m3 increment in PM2·5, 1·044 (1·019-1·069) per 10 μg/m3 NO2, and
AU  - Stafoggia,M
AU  - Oftedal,B
AU  - Chen,J
AU  - Rodopoulou,S
AU  - Renzi,M
AU  - Atkinson,RW
AU  - Bauwelinck,M
AU  - Klompmaker,JO
AU  - Mehta,A
AU  - Vienneau,D
AU  - Andersen,ZJ
AU  - Bellander,T
AU  - Brandt,J
AU  - Cesaroni,G
AU  - de,Hoogh K
AU  - Fecht,D
AU  - Gulliver,J
AU  - Hertel,O
AU  - Hoffmann,B
AU  - Hvidtfeldt,UA
AU  - Jöckel,K-H
AU  - Jørgensen,JT
AU  - Katsouyanni,K
AU  - Ketzel,M
AU  - Kristoffersen,DT
AU  - Lager,A
AU  - Leander,K
AU  - Liu,S
AU  - Ljungman,PLS
AU  - Nagel,G
AU  - Pershagen,G
AU  - Peters,A
AU  - Raaschou-Nielsen,O
AU  - Rizzuto,D
AU  - Schramm,S
AU  - Schwarze,PE
AU  - Severi,G
AU  - Sigsgaard,T
AU  - Strak,M
AU  - van,der Schouw YT
AU  - Verschuren,M
AU  - Weinmayr,G
AU  - Wolf,K
AU  - Zitt,E
AU  - Samoli,E
AU  - Forastiere,F
AU  - Brunekreef,B
AU  - Hoek,G
AU  - Janssen,NAH
DO  - 10.1016/S2542-5196(21)00277-1
EP  - 18
PY  - 2022///
SN  - 2542-5196
SP  - 9
TI  - Long-term exposure to low ambient air pollution concentrations and mortality among 28 million people: results from seven large European cohorts within the ELAPSE project
T2  - The Lancet Planetary Health
UR  - http://dx.doi.org/10.1016/S2542-5196(21)00277-1
UR  - https://www.ncbi.nlm.nih.gov/pubmed/34998464
UR  - http://hdl.handle.net/10044/1/93499
VL  - 6
ER  -
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