Imperial College London
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DrDanielaFecht

Faculty of Medicine, School of Public Health

Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 3314d.fecht

 
 
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Location

 

529Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Sheridan:2022:10.1016/j.envpol.2022.119686,
author = {Sheridan, C and Klompmaker, J and Cummins, S and James, P and Fecht, D and Roscoe, C},
doi = {10.1016/j.envpol.2022.119686},
journal = {Environmental Pollution},
title = {Associations of air pollution with COVID-19 positivity, hospitalisations, and mortality: observational evidence from UK Biobank},
url = {http://dx.doi.org/10.1016/j.envpol.2022.119686},
volume = {308},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Individual-level studies with adjustment for important COVID-19 risk factors suggest positive associations of long-term air pollution exposure (particulate matter and nitrogen dioxide) with COVID-19 infection, hospitalisations and mortality. The evidence, however, remains limited and mechanisms unclear. We aimed to investigate these associations within UK Biobank, and to examine the role of underlying chronic disease as a potential mechanism. UK Biobank COVID-19 positive laboratory testresults were ascertained via Public Health England and general practitioner record linkage, COVID-19 hospitalisations via Hospital Episode Statistics, and COVID-19 mortality via Office for National Statistics mortality records from March – December 2020. We used annual average outdoor air pollution modelled at 2010 residential addresses of UK Biobank participants who resided in England (n = 424,721). We obtained important COVID-19 risk factors from baseline UK Biobank questionnaire responses (2006-2010) and general practitioner record linkage. We used logistic regression models to assess associations of air pollution with COVID-19 outcomes, adjusted for relevant confounders, and conducted sensitivity analyses. We found positive associations of fine particulate matter (PM 2.5) and nitrogen dioxide (NO 2) with COVID-19 positive test result after adjustment for confounders and COVID-19 risk factors, with odds ratios of 1.05 (95% confidence intervals (CI) = 1.02, 1.08), and 1.05 (95% CI = 1.01, 1.08),88respectively. PM 2.5 and NO 2 were positively associated with COVID-19 hospitalisations and deaths in minimally adjusted models, but not in fully adjusted models. No associations for PM 10 were found. In analyses with additional adjustment for pre-existing chronic disease, effect estimates were not substantially attenuated, indicating that underlying chronic disease may not fully explain associations. We found some evidence that long-term exposure to PM 2.5 and NO 2 was associated wit
AU  - Sheridan,C
AU  - Klompmaker,J
AU  - Cummins,S
AU  - James,P
AU  - Fecht,D
AU  - Roscoe,C
DO  - 10.1016/j.envpol.2022.119686
PY  - 2022///
SN  - 0269-7491
TI  - Associations of air pollution with COVID-19 positivity, hospitalisations, and mortality: observational evidence from UK Biobank
T2  - Environmental Pollution
UR  - http://dx.doi.org/10.1016/j.envpol.2022.119686
UR  - https://www.sciencedirect.com/science/article/pii/S0269749122009009?via%3Dihub
UR  - http://hdl.handle.net/10044/1/98009
VL  - 308
ER  -
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