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@article{Hvidtfeldt:2022:10.1016/j.envres.2022.114385,
author = {Hvidtfeldt, UA and Taj, T and Chen, J and Rodopoulou, S and Strak, M and de, Hoogh K and Andersen, ZJ and Bellander, T and Brandt, J and Fecht, D and Forastiere, F and Gulliver, J and Hertel, O and Hoffmann, B and Jørgensen, JT and Katsouyanni, K and Ketzel, M and Lager, A and Leander, K and Ljungman, P and Magnusson, PKE and Nagel, G and Pershagen, G and Rizzuto, D and Samoli, E and So, R and Stafoggia, M and Tjønneland, A and Vermeulen, R and Weinmayr, G and Wolf, K and Zhang, J and Zitt, E and Brunekreef, B and Hoek, G and Raaschou-Nielsen, O},
doi = {10.1016/j.envres.2022.114385},
journal = {Environmental Research},
title = {Long term exposure to air pollution and kidney parenchyma cancer - Effects of low-level air pollution: a Study in Europe (ELAPSE)},
url = {http://dx.doi.org/10.1016/j.envres.2022.114385},
volume = {215},
year = {2022}
}

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TY  - JOUR
AB  - BACKGROUND: Particulate matter (PM) is classified as a group 1 human carcinogen. Previous experimental studies suggest that particles in diesel exhaust induce oxidative stress, inflammation and DNA damage in kidney cells, but the evidence from population studies linking air pollution to kidney cancer is limited. METHODS: We pooled six European cohorts (N = 302,493) to assess the association of residential exposure to fine particles (PM2.5), nitrogen dioxide (NO2), black carbon (BC), warm season ozone (O3) and eight elemental components of PM2.5 (copper, iron, potassium, nickel, sulfur, silicon, vanadium, and zinc) with cancer of the kidney parenchyma. The main exposure model was developed for year 2010. We defined kidney parenchyma cancer according to the International Classification of Diseases 9th and 10th Revision codes 189.0 and C64. We applied Cox proportional hazards models adjusting for potential confounders at the individual and area-level. RESULTS: The participants were followed from baseline (1985-2005) to 2011-2015. A total of 847 cases occurred during 5,497,514 person-years of follow-up (average 18.2 years). Median (5-95%) exposure levels of NO2, PM2.5, BC and O3 were 24.1 μg/m3 (12.8-39.2), 15.3 μg/m3 (8.6-19.2), 1.6 10-5 m-1 (0.7-2.1), and 87.0 μg/m3 (70.3-97.4), respectively. The results of the fully adjusted linear analyses showed a hazard ratio (HR) of 1.03 (95% confidence interval [CI]: 0.92, 1.15) per 10 μg/m³ NO2, 1.04 (95% CI: 0.88, 1.21) per 5 μg/m³ PM2.5, 0.99 (95% CI: 0.89, 1.11) per 0.5 10-5 m-1 BCE, and 0.88 (95% CI: 0.76, 1.02) per 10 μg/m³ O3. We did not find associations between any of the elemental components of PM2.5 and cancer of the kidney parenchyma. CONCLUSION: We did not observe an association between long-term ambient air pollution exposure and incidence of kidney parenchyma cancer.
AU  - Hvidtfeldt,UA
AU  - Taj,T
AU  - Chen,J
AU  - Rodopoulou,S
AU  - Strak,M
AU  - de,Hoogh K
AU  - Andersen,ZJ
AU  - Bellander,T
AU  - Brandt,J
AU  - Fecht,D
AU  - Forastiere,F
AU  - Gulliver,J
AU  - Hertel,O
AU  - Hoffmann,B
AU  - Jørgensen,JT
AU  - Katsouyanni,K
AU  - Ketzel,M
AU  - Lager,A
AU  - Leander,K
AU  - Ljungman,P
AU  - Magnusson,PKE
AU  - Nagel,G
AU  - Pershagen,G
AU  - Rizzuto,D
AU  - Samoli,E
AU  - So,R
AU  - Stafoggia,M
AU  - Tjønneland,A
AU  - Vermeulen,R
AU  - Weinmayr,G
AU  - Wolf,K
AU  - Zhang,J
AU  - Zitt,E
AU  - Brunekreef,B
AU  - Hoek,G
AU  - Raaschou-Nielsen,O
DO  - 10.1016/j.envres.2022.114385
PY  - 2022///
SN  - 0013-9351
TI  - Long term exposure to air pollution and kidney parenchyma cancer - Effects of low-level air pollution: a Study in Europe (ELAPSE)
T2  - Environmental Research
UR  - http://dx.doi.org/10.1016/j.envres.2022.114385
UR  - https://www.ncbi.nlm.nih.gov/pubmed/36154858
UR  - http://hdl.handle.net/10044/1/100099
VL  - 215
ER  -

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