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@article{Hvidtfeldt:2023:10.1158/1055-9965.EPI-22-0720,
author = {Hvidtfeldt, UA and Chen, J and Rodopoulou, S and Strak, M and de, Hoogh K and Andersen, ZJ and Bellander, T and Brandt, J and Fecht, D and Forastiere, F and Gulliver, J and Hertel, O and Hoffmann, BH and Katsouyanni, K and Ketzel, M and Brynedal, B and Leander, K and Ljungman, PLS and Magnusson, PKE and Nagel, G and Pershagen, G and Rizzuto, D and Boutron-Ruault, M-C and Samoli, E and So, R and Stafoggia, M and Tjonneland, A and Vermeulen, R and Verschuren, WMM and Weinmayr, G and Wolf, K and Zhang, J and Zitt, E and Brunekreef, B and Hoek, G and Raaschou-Nielsen, O},
doi = {10.1158/1055-9965.EPI-22-0720},
journal = {Cancer Epidemiology, Biomarkers and Prevention},
pages = {105--113},
title = {Breast cancer incidence in relation to long-term low-level exposure to air pollution in the ELAPSE pooled cohort},
url = {http://dx.doi.org/10.1158/1055-9965.EPI-22-0720},
volume = {32},
year = {2023}
}

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TY  - JOUR
AB  - Background:Established risk factors for breast cancer include genetic disposition, reproductive factors, hormone therapy, and lifestyle-related factors such as alcohol consumption, physical inactivity, smoking, and obesity. More recently a role of environmental exposures, including air pollution, has also been suggested. The aim of this study, was to investigate the relationship between long-term air pollution exposure and breast cancer incidence.Methods:We conducted a pooled analysis among six European cohorts (n = 199,719) on the association between long-term residential levels of ambient nitrogen dioxide (NO2), fine particles (PM2.5), black carbon (BC), and ozone in the warm season (O3) and breast cancer incidence in women. The selected cohorts represented the lower range of air pollutant concentrations in Europe. We applied Cox proportional hazards models adjusting for potential confounders at the individual and area-level.Results:During 3,592,885 person-years of follow-up, we observed a total of 9,659 incident breast cancer cases. The results of the fully adjusted linear analyses showed a HR (95% confidence interval) of 1.03 (1.00–1.06) per 10 μg/m³ NO2, 1.06 (1.01–1.11) per 5 μg/m³ PM2.5, 1.03 (0.99–1.06) per 0.5 10−5 m−1 BC, and 0.98 (0.94–1.01) per 10 μg/m³ O3. The effect estimates were most pronounced in the group of middle-aged women (50–54 years) and among never smokers.Conclusions:The results were in support of an association between especially PM2.5 and breast cancer.Impact:The findings of this study suggest a role of exposure to NO2, PM2.5, and BC in development of breast cancer.
AU  - Hvidtfeldt,UA
AU  - Chen,J
AU  - Rodopoulou,S
AU  - Strak,M
AU  - de,Hoogh K
AU  - Andersen,ZJ
AU  - Bellander,T
AU  - Brandt,J
AU  - Fecht,D
AU  - Forastiere,F
AU  - Gulliver,J
AU  - Hertel,O
AU  - Hoffmann,BH
AU  - Katsouyanni,K
AU  - Ketzel,M
AU  - Brynedal,B
AU  - Leander,K
AU  - Ljungman,PLS
AU  - Magnusson,PKE
AU  - Nagel,G
AU  - Pershagen,G
AU  - Rizzuto,D
AU  - Boutron-Ruault,M-C
AU  - Samoli,E
AU  - So,R
AU  - Stafoggia,M
AU  - Tjonneland,A
AU  - Vermeulen,R
AU  - Verschuren,WMM
AU  - Weinmayr,G
AU  - Wolf,K
AU  - Zhang,J
AU  - Zitt,E
AU  - Brunekreef,B
AU  - Hoek,G
AU  - Raaschou-Nielsen,O
DO  - 10.1158/1055-9965.EPI-22-0720
EP  - 113
PY  - 2023///
SN  - 1055-9965
SP  - 105
TI  - Breast cancer incidence in relation to long-term low-level exposure to air pollution in the ELAPSE pooled cohort
T2  - Cancer Epidemiology, Biomarkers and Prevention
UR  - http://dx.doi.org/10.1158/1055-9965.EPI-22-0720
UR  - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000908892700001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=a2bf6146997ec60c407a63945d4e92bb
UR  - https://aacrjournals.org/cebp/article/32/1/105/712626/Breast-Cancer-Incidence-in-Relation-to-Long-Term
UR  - http://hdl.handle.net/10044/1/102625
VL  - 32
ER  -

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