Imperial College London
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DrDanielaFecht

Faculty of Medicine, School of Public Health

Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 3314d.fecht

 
 
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Location

 

1119Sir Michael Uren HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Andersen:2022:10.1016/j.envint.2022.107581,
author = {Andersen, ZJ and Zhang, J and Jorgensen, JT and Samoli, E and Liu, S and Chen, J and Strak, M and Wolf, K and Weinmayr, G and Rodopolou, S and Remfry, E and de, Hoogh K and Bellander, T and Brandt, J and Concin, H and Zitt, E and Fecht, D and Forastiere, F and Gulliver, J and Hoffmann, B and Hvidtfeldt, UA and Verschuren, WMM and Joeckel, K-H and So, R and Cole-Hunter, T and Mehta, AJ and Mortensen, LH and Ketzel, M and Lager, A and Leander, K and Ljungman, P and Severi, G and Boutron-Ruault, M-C and Magnusson, PKE and Nagel, G and Pershagen, G and Peters, A and Rizzuto, D and van, der Schouw YT and Schramm, S and Stafoggia, M and Katsouyanni, K and Brunekreef, B and Hoek, G and Lim, Y-H},
doi = {10.1016/j.envint.2022.107581},
journal = {Environment International},
title = {Long-term exposure to air pollution and mortality from dementia, psychiatric disorders, and suicide in a large pooled European cohort: ELAPSE study},
url = {http://dx.doi.org/10.1016/j.envint.2022.107581},
volume = {170},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Ambient air pollution is an established risk factor for premature mortality from chronic cardiovascular, respiratory and metabolic diseases, while evidence on neurodegenerative diseases and psychiatric disorders remains limited. We examined the association between long-term exposure to air pollution and mortality from dementia, psychiatric disorders, and suicide in seven European cohorts. Within the multicenter project ‘Effects of Low-Level Air Pollution: A Study in Europe’ (ELAPSE), we pooled data from seven European cohorts from six countries. Based on the residential addresses, annual mean levels of fine particulate matter (PM2.5), nitrogen dioxide (NO2), black carbon (BC), ozone (O3), and 8 PM2.5 components were estimated using Europe-wide hybrid land-use regression models. We applied stratified Cox proportional hazard models to investigate the associations between air pollution and mortality from dementia, psychiatric disorders, and suicide. Of 271,720 participants, 900 died from dementia, 241 from psychiatric disorders, and 164 from suicide, during a mean follow-up of 19.7 years. In fully adjusted models, we observed positive associations of NO2 (hazard ratio [HR] = 1.38; 95 % confidence interval [CI]: 1.13, 1.70 per 10 µg/m3), PM2.5 (HR = 1.29; 95 % CI: 0.98, 1.71 per 5 µg/m3), and BC (HR = 1.37; 95 % CI: 1.11, 1.69 per 0.5 × 10−5/m) with psychiatric disorders mortality, as well as with suicide (NO2: HR = 1.13 [95 % CI: 0.92, 1.38]; PM2.5: HR = 1.19 [95 % CI: 0.76, 1.87]; BC: HR = 1.08 [95 % CI: 0.87, 1.35]), and no association with dementia mortality. We did not detect any positive associations of O3 and 8 PM2.5 components with any of the three mortality outcomes. Long-term exposure to NO2, PM2.5, and BC may lead to premature mortality from psychiatric disorders and suicide.
AU  - Andersen,ZJ
AU  - Zhang,J
AU  - Jorgensen,JT
AU  - Samoli,E
AU  - Liu,S
AU  - Chen,J
AU  - Strak,M
AU  - Wolf,K
AU  - Weinmayr,G
AU  - Rodopolou,S
AU  - Remfry,E
AU  - de,Hoogh K
AU  - Bellander,T
AU  - Brandt,J
AU  - Concin,H
AU  - Zitt,E
AU  - Fecht,D
AU  - Forastiere,F
AU  - Gulliver,J
AU  - Hoffmann,B
AU  - Hvidtfeldt,UA
AU  - Verschuren,WMM
AU  - Joeckel,K-H
AU  - So,R
AU  - Cole-Hunter,T
AU  - Mehta,AJ
AU  - Mortensen,LH
AU  - Ketzel,M
AU  - Lager,A
AU  - Leander,K
AU  - Ljungman,P
AU  - Severi,G
AU  - Boutron-Ruault,M-C
AU  - Magnusson,PKE
AU  - Nagel,G
AU  - Pershagen,G
AU  - Peters,A
AU  - Rizzuto,D
AU  - van,der Schouw YT
AU  - Schramm,S
AU  - Stafoggia,M
AU  - Katsouyanni,K
AU  - Brunekreef,B
AU  - Hoek,G
AU  - Lim,Y-H
DO  - 10.1016/j.envint.2022.107581
PY  - 2022///
SN  - 0160-4120
TI  - Long-term exposure to air pollution and mortality from dementia, psychiatric disorders, and suicide in a large pooled European cohort: ELAPSE study
T2  - Environment International
UR  - http://dx.doi.org/10.1016/j.envint.2022.107581
UR  - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000882422200008&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/100981
VL  - 170
ER  -
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