Imperial College London
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ProfessorDavidFirmin

Faculty of Medicine, National Heart & Lung Institute

Emeritus Professor of Biomedical Imaging
 
 
 
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Contact

 

+44 (0)20 7351 8801d.firmin

 
 
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Location

 

Cardiovascular MR UnitRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Liu:2021:10.1136/heartjnl-2020-317949,
author = {Liu, T and Gao, Y and Wang, H and Zhou, Z and Wang, R and Chang, S and Liu, Y and Sun, Y and Rui, H and Yang, G and Firmin, D and Dong, J and Xu, L},
doi = {10.1136/heartjnl-2020-317949},
journal = {Heart},
pages = {1233--1239},
title = {Association between right ventricular strain and outcomes in patients with dilated cardiomyopathy},
url = {http://dx.doi.org/10.1136/heartjnl-2020-317949},
volume = {107},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Objective To explore the association between three-dimensional (3D) cardiac magnetic resonance (CMR) feature tracking (FT) right ventricular peak global longitudinal strain (RVpGLS) and major adverse cardiovascular events (MACEs) in patients with stage C or D heart failure (HF) with non-ischaemic dilated cardiomyopathy (NIDCM) but without atrial fibrillation (AF).Methods Patients with dilated cardiomyopathy were enrolled in this prospective cohort study. Comprehensive clinical and biochemical analysis and CMR imaging were performed. All patients were followed up for MACEs.Results A total of 192 patients (age 53±14 years) were eligible for this study. A combination of cardiovascular death and cardiac transplantation occurred in 18 subjects during the median follow-up of 567 (311, 920) days. Brain natriuretic peptide, creatinine, left ventricular (LV) end-diastolic volume, LV end-systolic volume, right ventricular (RV) end-diastolic volume and RVpGLS from CMR were associated with the outcomes. The multivariate Cox regression model adjusting for traditional risk factors and CMR variables detected a significant association between RVpGLS and MACEs in patients with stage C or D HF with NIDCM without AF. Kaplan-Meier analysis based on RVpGLS cut-off value revealed that patients with RVpGLS <−8.5% showed more favourable clinical outcomes than those with RVpGLS ≥−8.5% (p=0.0037). Subanalysis found that this association remained unchanged.Conclusions RVpGLS-derived from 3D CMR FT is associated with a significant prognostic impact in patients with NIDCM with stage C or D HF and without AF.
AU  - Liu,T
AU  - Gao,Y
AU  - Wang,H
AU  - Zhou,Z
AU  - Wang,R
AU  - Chang,S
AU  - Liu,Y
AU  - Sun,Y
AU  - Rui,H
AU  - Yang,G
AU  - Firmin,D
AU  - Dong,J
AU  - Xu,L
DO  - 10.1136/heartjnl-2020-317949
EP  - 1239
PY  - 2021///
SN  - 1355-6037
SP  - 1233
TI  - Association between right ventricular strain and outcomes in patients with dilated cardiomyopathy
T2  - Heart
UR  - http://dx.doi.org/10.1136/heartjnl-2020-317949
UR  - https://heart.bmj.com/content/107/15/1233
UR  - http://hdl.handle.net/10044/1/84829
VL  - 107
ER  -
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