Publications
712 results found
Salukhe TV, Francis DP, Sutton R, 2003, Comparison of medical therapy, pacing and defibrillation in heart failure (COMPANION) trial terminated early; combined biventricular pacemaker-defibrillators reduce all-cause mortality and hospitalization, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 87, Pages: 119-120, ISSN: 0167-5273
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- Citations: 64
Willson K, Francis DP, 2003, A direct analytical demonstration of the essential equivalence of detrended fluctuation analysis and spectral analysis of RR interval variability, PHYSIOLOGICAL MEASUREMENT, Vol: 24, Pages: N1-N7, ISSN: 0967-3334
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- Citations: 27
Duncan AM, Francis DP, Henein MY, et al., 2003, Limitation of cardiac output by total isovolumic time during pharmacologic stress in patients with dilated cardiomyopathy - Activation-mediated effects of left bundle branch block and coronary artery disease, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 41, Pages: 121-128, ISSN: 0735-1097
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- Citations: 41
Francis D, 2003, American Heart Association Scientific Sessions 2002. Chicago, IL, USA, November 9-12, 2002., Heart Fail Monit, Vol: 3, Pages: 115-116, ISSN: 1470-8590
Francis DP, Davies LC, Willson K, et al., 2002, Impact of periodic breathing on measurement of oxygen uptake and respiratory exchange ratio during cardiopulmonary exercise testing, CLINICAL SCIENCE, Vol: 103, Pages: 543-552, ISSN: 0143-5221
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- Citations: 15
Anker SD, Sharma R, Francis D, et al., 2002, Anemia and survival in 3044 patients with chronic heart failure (CHF) in the ELITE II trial, American-Heart-Association Abstracts From Scientific Sessions, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 472-472, ISSN: 0009-7322
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- Citations: 8
Davies LC, Francis DP, Piepoli MF, et al., 2002, Enhanced prognostic value from cardiopulmonary exercise testing in chronic heart failure by non-linear analysis - Oxygen uptake efficiency slope, American-Heart-Association Abstracts From Scientific Sessions, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 330-330, ISSN: 0009-7322
Davies LC, Francis DP, Willson K, et al., 2002, Abnormal temporal dynamics of blood pressure and RR interval regulation in patients with chronic heart failure: relationship to baroreflex sensitivity, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 86, Pages: 107-114, ISSN: 0167-5273
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- Citations: 5
Davos CH, Davlouros PA, Wensel R, et al., 2002, Global impairment of cardiac autonomic nervous activity late after repair of tetralogy of Fallot, CIRCULATION, Vol: 106, Pages: I69-I75, ISSN: 0009-7322
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- Citations: 60
Davos CH, Davlouros PA, Wensel R, et al., 2002, Global impairment of cardiac autonomic nervous activity late after repair of Tetralogy of Fallot, Circulation, Vol: 106, ISSN: 0009-7322
Background - Sustained ventricular tachycardia (VT) and sudden cardiac death (SCD) remain devastating late complications after repair of Tetralogy of Fallot (ToF). Although heart rate variability (HRV) and baroreflex sensitivity (BRS) are recognized as independent markers of autonomic activity and strong predictors of SCD in major cardiovascular disease, little is known about their role in patients with tertralogy. Methods and Results - We measured HRV and BRS in 45 ToF patients (27 male, age 35±12 years, 26±7 years after repair) and 45 matched healthy controls. Subjects underwent 20 minute of resting measurements of heart rate (ECG) and noninvasive beat-to-beat blood pressure recording (Finapres), with 5 minutes of 0.1 Hz controlled breathing followed by cardiac MRI. BRS was computed by spectral analysis and the sequence and controlled breathing methods. All HRV time and frequency domain variables were measured. All BRS and HRV variables were significantly reduced in patients compared with controls (P<0.001 in all). HRV tended to increase with years from repair. BRS decreased with previous palliation and increasing patient age. Both HRV and BRS decreased with pulmonary regurgitation, elevated right ventricular end systolic volumes and reduced right and left ventricular ejection fraction. Finally, there was an inverse relation between QRS duration (predictor of sustained VT and SCD) and indices of HRV but no relation with indices of BRS. Conclusion - There is global impairment of autonomic nervous system regulation late after repair of tetralogy with marked reduction of BRS and HRV. This seems to relate to previous surgical intervention/s, their timing and current right and left-sided hemodynamics. Reduced HRV also related to markers of sustained VT and SCD, suggesting possible common pathogenic mechanisms. Further studies are required to examine the prognostic significance of impaired BRS and HRV in these patients.
Arshad W, Francis DP, Duncan AM, et al., 2002, Opposite effects of coronary artery disease and hypertrophic cardiomyopathy on left ventricular long axis physiology during dobutamine stress, Congress of the European-Society-of-Cardiology, Publisher: W B SAUNDERS CO LTD, Pages: 58-58, ISSN: 0195-668X
Wensel R, Georgladou R, Francis DP, et al., 2002, Contribution of alveolar and serial dead space to the hyperpnoea of exercise in chronic heart failure, Congress of the European-Society-of-Cardiology, Publisher: W B SAUNDERS CO LTD, Pages: 79-79, ISSN: 0195-668X
Kaczmarek A, Jankowska EA, Witkowski T, et al., 2002, Contribution of ergoreflex to respiratory control in chronic heart failure - the reproducibility and the clinical implications of the method, Congress of the European-Society-of-Cardiology, Publisher: W B SAUNDERS CO LTD, Pages: 80-80, ISSN: 0195-668X
Francis DP, Willson K, Georgiadou P, et al., 2002, Physiological basis of fractal complexity properties of heart rate variability in man, JOURNAL OF PHYSIOLOGY-LONDON, Vol: 542, Pages: 619-629, ISSN: 0022-3751
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- Citations: 57
Rauchhaus M, Gross M, Schulz S, et al., 2002, The E-selectin SER128ARG gene polymorphism and restenosis after successful coronary angioplasty, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 83, Pages: 249-257, ISSN: 0167-5273
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- Citations: 40
Willson K, Francis DP, Wensel R, et al., 2002, Relationship between detrended fluctuation analysis and spectral analysis of heart-rate variability, PHYSIOLOGICAL MEASUREMENT, Vol: 23, Pages: 385-401, ISSN: 0967-3334
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- Citations: 60
Davies LC, Colhoun H, Coats AJS, et al., 2002, A noninvasive measure of baroreflex sensitivity without blood pressure measurement, AMERICAN HEART JOURNAL, Vol: 143, Pages: 441-447, ISSN: 0002-8703
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- Citations: 22
Francis DP, 2002, How many consultants should you invite to a meeting to ensure it will never happen?, BMJ, Vol: 341, ISSN: 0959-8138
Henein M, Lindqvist P, Francis D, et al., 2002, Tissue Doppler analysis of age-dependency in diastolic ventricular behaviour and filling -: A cross-sectional study of healthy hearts (the Umea General Population Heart Study), EUROPEAN HEART JOURNAL, Vol: 23, Pages: 162-171, ISSN: 0195-668X
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- Citations: 85
Francis D, 2002, Major heart failure news from 2001., Heart Fail Monit, Vol: 2, Pages: 147-148, ISSN: 1470-8590
Ponikowski PP, Chua TP, Francis DP, et al., 2001, Muscle ergoreceptor overactivity reflects deterioration in clinical status and cardiorespiratory reflex control in chronic heart failure, CIRCULATION, Vol: 104, Pages: 2324-2330, ISSN: 0009-7322
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- Citations: 183
Arshad W, Duncan A, Francis D, et al., 2001, Cardiac physiology at rest and peak dobutamine stress in patients with hypertrophic cardiomyopathy, CIRCULATION, Vol: 104, Pages: 430-430, ISSN: 0009-7322
Piepoli M, Wensel R, Ponikowski PP, et al., 2001, Ergoreflex overactivation predicts reduced baroreflex sensitivity and autonomic abnormalities in chronic heart failure patients, EUROPEAN HEART JOURNAL, Vol: 22, Pages: 548-548, ISSN: 0195-668X
Francis D, Lane R, Mayet J, et al., 2001, Microvolt T wave alternans in patients with hypertension and left ventricular hypertrophy, JOURNAL OF HUMAN HYPERTENSION, Vol: 15, Pages: S95-S96, ISSN: 0950-9240
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- Citations: 5
Shamim W, Yousufuddin M, Francis DP, et al., 2001, Raised urinary glucocorticoid and adrenal androgen precursors in the urine of young hypertensive patients: possible evidence for partial glucocorticoid resistance, HEART, Vol: 86, Pages: 139-144, ISSN: 1355-6037
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- Citations: 8
Ponikowski P, Chua TP, Anker SD, et al., 2001, Peripheral chemoreceptor hypersensitivity - An ominous sign in patients with chronic heart failure, CIRCULATION, Vol: 104, Pages: 544-549, ISSN: 0009-7322
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- Citations: 226
Francis DP, Davies LC, Coats AJS, 2001, Diagnostic exercise physiology in chronic heart failure, HEART, Vol: 86, Pages: 17-20, ISSN: 1355-6037
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- Citations: 7
Davies LC, Francis DP, Scott AC, et al., 2001, Effect of altering conditions of the sequence method on baroreflex sensitivity, JOURNAL OF HYPERTENSION, Vol: 19, Pages: 1279-1287, ISSN: 0263-6352
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- Citations: 33
Scott AC, Francis DP, Davies LC, et al., 2001, Validation of a treadmill exercise test protocol with improved metabolic plateau formation in patients with chronic congestive heart failure, AMERICAN JOURNAL OF CARDIOLOGY, Vol: 87, Pages: 1328-1331, ISSN: 0002-9149
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- Citations: 9
Marinone MG, Al-Nasser F, Francis D, et al., 2001, Beta-blocking in heart failure patients - Balancing the evidence, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 79, Pages: 5-12, ISSN: 0167-5273
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- Citations: 3
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