Imperial College London
Alternate

ProfessorDuncanGeddes

Faculty of Medicine, National Heart & Lung Institute

Emeritus Professor of Respiratory Medicine
 
 
 
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Contact

 

+44 (0)20 7351 8182d.geddes

 
 
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Location

 

Royal BromptonRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Elkin:2003:10.1586/14787210.1.4.609,
author = {Elkin, S and Geddes, D},
doi = {10.1586/14787210.1.4.609},
journal = {Expert Rev Anti Infect Ther},
pages = {609--618},
title = {Pseudomonal infection in cystic fibrosis: the battle continues.},
url = {http://dx.doi.org/10.1586/14787210.1.4.609},
volume = {1},
year = {2003}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Pseudomonas aeruginosa lung infection is the major cause of morbidity and mortality in patients with cystic fibrosis. Infection usually begins in childhood and is responsible for respiratory failure and death in most patients with cystic fibrosis. The organism triggers an exuberant chronic inflammatory reaction which damages the airways and leads to progressive loss of lung function. Over the last decade significant advances have been made in the understanding of the pathophysiology of cystic fibrosis airways disease. These should assist the development of new and better therapies to treat this pathogen. This review provides an overview of pseudomonal infection in cystic fibrosis, including mechanisms by which the bacteria may colonize the cystic fibrosis airway, persistence of pseudomonal infection and the biofilm mode of growth. Available treatments and possible novel approaches to therapy will be discussed.
AU  - Elkin,S
AU  - Geddes,D
DO  - 10.1586/14787210.1.4.609
EP  - 618
PY  - 2003///
SN  - 1478-7210
SP  - 609
TI  - Pseudomonal infection in cystic fibrosis: the battle continues.
T2  - Expert Rev Anti Infect Ther
UR  - http://dx.doi.org/10.1586/14787210.1.4.609
UR  - https://www.ncbi.nlm.nih.gov/pubmed/15482158
VL  - 1
ER  -
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