Imperial College London

DrDavidGoldmeier

Faculty of MedicineDepartment of Infectious Disease

Honorary Senior Lecturer
 
 
 
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d.goldmeier

 
 
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Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Publication Type
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88 results found

Mills E, Ertl N, Wall M, Thurston L, Yang L, Suladze S, Hunjan T, Phylactou M, Patel B, Muzi B, Ettehad D, Bassett P, Howard J, Rabiner E, Bech P, Abbara A, Goldmeier D, Comninos A, Dhillo Wet al., 2023, Effects of kisspeptin on sexual brain processing and penile tumescence in men with hypoactive sexual desire disorder: a randomized clinical trial, Jama Network Open, Vol: 6, Pages: 1-16, ISSN: 2574-3805

Importance The human physiological sexual response is crucial for reward, satisfaction, and reproduction. Disruption of the associated neurophysiological pathways predisposes to low sexual desire; the most prevalent psychological form is hypoactive sexual desire disorder (HSDD), which affects 8% of men but currently has no effective pharmacological treatment options. The reproductive neuropeptide kisspeptin offers a putative therapeutic target, owing to emerging understanding of its role in reproductive behavior.Objective To determine the physiological, behavioral, neural, and hormonal effects of kisspeptin administration in men with HSDD.Design, Setting, and Participants This double-blind, 2-way crossover, placebo-controlled randomized clinical trial was performed at a single academic research center in the UK. Eligible participants were right-handed heterosexual men with HSDD. Physiological, behavioral, functional magnetic resonance imaging (fMRI), and hormonal analyses were used to investigate the clinical and mechanistic effects of kisspeptin administration in response to visual sexual stimuli (short and long video tasks). The trial was conducted between January 11 and September 15, 2021, and data analysis was performed between October and November 2021.Interventions Participants attended 2 study visits at least 7 days apart, in balanced random order, for intravenous infusion of kisspeptin-54 (1 nmol/kg/h) for 75 minutes or for administration of a rate-matched placebo.Main Outcomes and Measures Changes in (1) brain activity on whole-brain analysis, as determined by fMRI blood oxygen level–dependent activity in response to visual sexual stimuli during kisspeptin administration compared with placebo, (2) physiological sexual arousal (penile tumescence), and (3) behavioral measures of sexual desire and arousal.Results Of the 37 men randomized, 32 completed the trial. Participants had a mean (SD) age of 37.9 (8.6) years and a mean (SD) body mass i

Journal article

Thurston L, Hunjan T, Ertl N, Wall M, Mills E, Suladze S, Patel B, Alexander E, Muzi B, Bassett P, Rabiner E, Bech P, Goldmeier D, Abbara A, Comninos A, Dhillo Wet al., 2022, Effects of kisspeptin administration in women with hypoactive sexual desire disorder: a randomized clinical trial, Jama Network Open, Vol: 5, Pages: 1-14, ISSN: 2574-3805

Importance: The absence or deficiency of sexual desire leading to distress or interpersonal difficultydefines ‘hypoactive sexual desire disorder’ (HSDD). Despite being the most common female sexualhealth complaint worldwide, current treatment options for HSDD are limited in their safety andeffectiveness. The hormone kisspeptin is a key endogenous activator of the reproductive hormonalaxis with additional emerging roles in sexual and emotional behavior, however, its effects in womenwith HSDD are unknown.Objective: To test the hypothesis that kisspeptin enhances sexual and attraction brain processing inwomen with HSDD.Design: A randomized, double-blind, two-way crossover, placebo-controlled clinical trial. Functionalneuroimaging, psychometric and hormonal analyses were employed to investigate the effects ofkisspeptin administration on brain processing, in response to erotic stimuli (erotic videos) and facialattraction (face images of varying attractiveness).Setting: The trial was conducted in a university research setting from October 2020 to April 2021. Datawere analyzed from May to December 2021.Participants: 32 premenopausal women with HSDD for at least 6 months’ duration.Interventions: 75-minute intravenous infusion of kisspeptin-54 (1 nmol/kg/h) vs equivalent-rateplacebo infusion.Main Outcome and Measures: Blood oxygen level–dependent responses across the whole brain andregions of interest during kisspeptin vs placebo administration, in response to erotic and facialattraction stimuli.Results: Of the 40 participants who were randomized, 32 women completed both kisspeptin andplacebo visits, and the mean (SEM) age was 29.2 (1.2) years. Kisspeptin administration resulted inmodulations in sexual and facial attraction brain processing (all P<.05). Furthermore, positivecorrelations were observed between kisspeptin-enhanced hippocampal activity in response to eroticvideos, and baseline distress relating to sexual function (P<.01). In additio

Journal article

Thurston L, Hunjan T, Mills E, Wall M, Ertl N, Phylactou M, Muzi B, Patel B, Alexander E, Suladze S, Modi M, Eng P, Bassett P, Abbara A, Goldmeier D, Comninos A, Dhillo Wet al., 2022, Melanocortin 4 receptor agonism enhances sexual brain processing in women with hypoactive sexual desire disorder, Journal of Clinical Investigation, Vol: 132, Pages: 1-12, ISSN: 0021-9738

BACKGROUND. Hypoactive sexual desire disorder (HSDD) is characterized by a persistent deficiency of sexual fantasies and desire for sexual activity, causing marked distress and interpersonal difficulty. It is the most prevalent female sexual health problem globally, affecting approximately 10% of women, but has limited treatment options. Melanocortin 4 receptor (MC4R) agonists have emerged as a promising therapy for women with HSDD, through unknown mechanisms. Studying the pathways involved is crucial for our understanding of normal and abnormal sexual behavior.METHODS. Using psychometric, functional neuroimaging, and hormonal analyses, we conducted a randomized, double-blinded, placebo-controlled, crossover clinical study to assess the effects of MC4R agonism compared with placebo on sexual brain processing in 31 premenopausal heterosexual women with HSDD.RESULTS. MC4R agonism significantly increased sexual desire for up to 24 hours after administration compared with placebo. During functional neuroimaging, MC4R agonism enhanced cerebellar and supplementary motor area activity and deactivated the secondary somatosensory cortex, specifically in response to visual erotic stimuli, compared with placebo. In addition, MC4R agonism enhanced functional connectivity between the amygdala and the insula during visual erotic stimuli compared with placebo.CONCLUSION. These data suggest that MC4R agonism enhanced sexual brain processing by reducing self-consciousness, increasing sexual imagery, and sensitizing women with HSDD to erotic stimuli. These findings provide mechanistic insight into the action of MC4R agonism in sexual behavior and are relevant to the ongoing development of HSDD therapies and MC4R agonist development more widely.TRIAL REGISTRATION. ClinicalTrials.gov NCT04179734.FUNDING. This is an investigator-sponsored study funded by AMAG Pharmaceuticals Inc., the Medical Research Council (MRC) (MR/T006242/1), and the National Institute for Health Research (NIHR) (C

Journal article

Richardson D, Goldmeier D, 2022, Probenecid in the treatment of neurosyphilis in men who have sex with men: a commentary, SEXUALLY TRANSMITTED INFECTIONS, Vol: 98, Pages: 459-459, ISSN: 1368-4973

Journal article

Hunjan T, Thurston L, Ertl N, Wall M, Mills E, Suladze S, Patel B, Alexander E, Muzi B, Rabiner E, Bech P, Goldmeier D, Abbara A, Comninos A, Dhillo Wet al., 2022, Kisspeptin modulates sexual brain processing in women with low sexual desire, Publisher: WILEY, Pages: 200-200, ISSN: 1470-0328

Conference paper

Shiva F, Short C-E, Goldmeier D, Winston Aet al., 2022, Predictive value of neurological symptoms in persons with suspected neurosyphilis, SEXUALLY TRANSMITTED INFECTIONS, Vol: 98, Pages: 228-229, ISSN: 1368-4973

Journal article

Hunjan T, Thurston L, Mills E, Wall M, Ertl N, Phylactou M, Muzi B, Patel B, Alexander E, Suladze S, Modi M, Eng P, Bassett P, Abbara A, Goldmeier D, Comninos A, Dhillo Wet al., 2022, MELANOCORTIN-4 RECEPTOR AGONISM MODULATES SEXUAL BRAIN PROCESSING IN WOMEN WITH LOW SEXUAL DESIRE, Publisher: ELSEVIER SCI LTD, Pages: S123-S123, ISSN: 1743-6095

Conference paper

Richardson D, Siddiqi A, Parashar K, Fitzpatrick C, Pinto-Sander N, Goldmeier Det al., 2021, A Pilot Study Evaluating Antimicrobial Antagonism in Syphilis/Chlamydia trachomatis Co-Infection in Men Who Have Sex with Men, EUROPEAN JOURNAL OF THERAPEUTICS, Vol: 27, Pages: 327-328, ISSN: 2564-7784

Journal article

Shiva F, Goldmeier D, Lane P, Ethiopia H, Winston Aet al., 2020, Cerebrospinal fluid TPPA titres in the diagnosis of neurosyphilis, SEXUALLY TRANSMITTED INFECTIONS, Vol: 96, Pages: 389-390, ISSN: 1368-4973

Journal article

Ashby J, Ahmed N, Goldmeier D, 2019, Sexual difficulties service provision within sexual health services in the UK: a casualty of postcode lottery and commissioning?, SEXUALLY TRANSMITTED INFECTIONS, Vol: 95, Pages: 397-397, ISSN: 1368-4973

Journal article

Thakrar P, Aclimandos W, Goldmeier D, Setterfield JFet al., 2019, Vegetating lesions in secondary syphilis. Reply from authors, CLINICAL AND EXPERIMENTAL DERMATOLOGY, Vol: 44, Pages: 469-470, ISSN: 0307-6938

Journal article

Hollows K, Goldmeier D, 2019, The ABC of Sexual Dysfunction conference., Sex Transm Infect, Vol: 95

Journal article

Thakrar P, Aclimandos W, Goldmeier D, Setterfield JFet al., 2018, Oral ulcers as a presentation of secondary syphilis, CLINICAL AND EXPERIMENTAL DERMATOLOGY, Vol: 43, Pages: 868-875, ISSN: 0307-6938

Journal article

Ashby J, Ahmed N, Goldmeier D, 2018, Provision of sexual difficulties service within sexual health services: postcode lottery and commissioning casualty?, Publisher: WILEY, Pages: S118-S118, ISSN: 1464-2662

Conference paper

Nyatsanza F, Goldmeier D, 2016, "PERSISTENT GENITAL AROUSAL DISORDER - THE EXPERIENCE OF A LONDON TEACHING HOSPITAL", Publisher: BMJ PUBLISHING GROUP, Pages: A15-A15, ISSN: 1368-4973

Conference paper

Oomeer S, Alagaratnam J, Lyall H, Gurtin D, Goldmeier Det al., 2015, Seven years of undiagnosed syphilis: a missed opportunity for mother and child, INTERNATIONAL JOURNAL OF STD & AIDS, Vol: 26, Pages: 982-984, ISSN: 0956-4624

Journal article

Mora-Peris B, Else L, Goldmeier D, Mears A, Weston R, Graham C, Khoo S, Back D, Winston Aet al., 2015, A PHASE 1 STUDY TO ASSESS THE SAFETY, TOLERABILITY AND PHARMACOKINETIC PROFILE OF BOCEPREVIR AND SILDENAFIL WHEN DOSED SEPARATELY AND TOGETHER, IN HEALTHY MALE VOLUNTEERS, SEXUALLY TRANSMITTED INFECTIONS, Vol: 91, Pages: A78-A78, ISSN: 1368-4973

Journal article

Mora-Peris B, Else L, Goldmeier D, Mears A, Weston R, Cooke G, Khoo S, Back D, Winston Aet al., 2015, A Phase I study to assess the safety, tolerability and pharmacokinetic profile of boceprevir and sildenafil when dosed separately and together, in healthy male volunteers, JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, Vol: 70, Pages: 1812-1815, ISSN: 0305-7453

Journal article

Jiang P, McCarty E, Ashby J, Goldmeier D, Sadeghi-Nejad Het al., 2014, ASSESSING EXPERIENCE AND OUTCOMES WITH COMBINED USE OF PHOSPHODIESTERASE-5 INHIBITORS IN ERECTILE DYSFUNCTION TREATMENT, JOURNAL OF SEXUAL MEDICINE, Vol: 11, Pages: 195-196, ISSN: 1743-6095

Journal article

Garvey L, Bains K, Greene L, Goldmeier D, VanEyk Jet al., 2014, Is appropriate evaluation of male subjects with chronic pelvic pain feasible within a specialist GU service?, HIV MEDICINE, Vol: 15, Pages: 155-155, ISSN: 1464-2662

Journal article

Ashby J, Goldmeier D, Sadeghi-Nejad H, 2014, Hypogonadism in human immunodeficiency virus-positive men., Korean J Urol, Vol: 55, Pages: 9-16, ISSN: 2005-6737

In recent years, the life expectancy for those living with human immunodeficiency virus (HIV) with access to combined antiretroviral therapy (cART) has increased. As men live longer, the role testosterone plays in sexual function as well as in general well-being is becoming increasingly important. Here we discuss the available literature concerning androgens and HIV disease. A review was undertaken by using a PubMed search with the umbrella terms HIV or AIDS and testosterone or androgens spanning 1985 to 2011. Significant articles found in references in the primary search were also included. The reported prevalence of androgen deficiency appears to be greater in HIV-infected males than in the general population. Androgen deficiency is usually associated with low luteinizing hormone and follicle-stimulating hormone and is sensitive to the type of measurement of testosterone used. Rates of hypogonadism may be falling since the advent of cART. Causes of low testosterone levels have been attributed to chronic illness, HIV replication, cART, opportunistic infections, comorbidities and coinfections, wasting, and normal age-related declines. Studies of testosterone treatment in HIV-positive men are lacking in standardization and outcome measures.

Journal article

Brookings C, Goldmeier D, Sadeghi-Nejad H, 2013, Sexually transmitted infections and sexual function in relation to male fertility., Korean J Urol, Vol: 54, Pages: 149-156, ISSN: 2005-6737

Infertility affects about 8% to 12% of couples, with male infertility being responsible for about 30% of cases. Sexually transmitted infections (STIs) are known to cause complications of pregnancy and are associated with tubal infertility in females, but the association with male fertility is still controversial. The prevalence of curable STIs has risen to an estimated 448 million a year with the number of people living with human immunodeficiency virus (HIV) at 34 million. This review looks at the evidence available to date, regarding the effect of STIs and male accessory gland infections on markers of male fertility and the evidence that STIs negatively affect sexual functioning, thus adversely affecting the ability to conceive. The review will also cover new developments in the use of medications and fertility treatments as an aid to conception in couples serodiscordant for HIV.

Journal article

Goldmeier D, 2013, Mindfulness: a sexual medicine physician's personal and professional journey, SEXUAL AND RELATIONSHIP THERAPY, Vol: 28, Pages: 77-83, ISSN: 1468-1994

Journal article

Facelle TM, Sadeghi-Nejad H, Goldmeier D, 2013, Persistent Genital Arousal Disorder: Characterization, Etiology, and Management, JOURNAL OF SEXUAL MEDICINE, Vol: 10, Pages: 439-450, ISSN: 1743-6095

Journal article

McCarty E, Hollow K, Sadeghi-Nejad H, Ashby J, Goldmeier Det al., 2012, ASSESSING EXPERIENCE AND OUTCOMES WITH COMBINED USE OF PHOSPHODIESTERASE-5 INHIBITORS IN ERECTILE DYSFUNCTION TREATMENT, JOURNAL OF SEXUAL MEDICINE, Vol: 9, Pages: 317-317, ISSN: 1743-6095

Journal article

Sacks R, Tipple C, Goldmeier D, 2012, MANAGING THE CARDIOVASCULAR COMPLICATIONS OF LATE SYPHILIS, SEXUALLY TRANSMITTED INFECTIONS, Vol: 88, Pages: A30-A30, ISSN: 1368-4973

Journal article

Vera J, Garvey L, Tipple C, Goldmeier D, Winston Aet al., 2012, A past history of syphilis is associated with poorer performance in the cognitive domains of memory and learning in HIV-infected subjects on stable cART, HIV MEDICINE, Vol: 13, Pages: 51-51, ISSN: 1464-2662

Journal article

Tipple C, Hanna MOF, Hill S, Daniel J, Goldmeier D, McClure MO, Taylor GPet al., 2011, Getting the measure of syphilis: qPCR to better understand early infection, SEXUALLY TRANSMITTED INFECTIONS, Vol: 87, Pages: 479-485, ISSN: 1368-4973

Journal article

Goldmeier D, Petrak J, 2011, How to recognise sexual addiction in the sexual health clinic setting?, Sex Transm Infect, Vol: 87, Pages: 370-371

Journal article

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