Imperial College London

Dr Daniel Gonçalves-Carneiro

Faculty of MedicineDepartment of Infectious Disease

Imperial College Research Fellow
 
 
 
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Contact

 

d.goncalves-carneiro

 
 
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Location

 

457St Mary's Research BuildingSt Mary's Campus

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Summary

 

Summary

Daniel Gonçalves-Carneiro graduated from the University of Porto, Portugal, with an integrated masters in Bioengineering. He received his PhD from the University of Birmingham, UK, for his work on measles virus infection under the guidance of Dr Dalan Bailey. Daniel later moved to the Rockefeller University, in New York, where he joined Professor Paul Bieniasz's lab. There, he studied how certain RNA viruses are sensed by the zinc finger antiviral protein (ZAP), inhibiting virus replication. He showed that while human ZAP specifically recognises CpG dinucleotides in virus RNA, zinc finger antiviral proteins from many species of birds have distinct binding preferences. By characterising RNA binding preferences of human ZAP, he engineered genomes of enterovirus A71 with enhanced sensitivity to ZAP to generate stably attenuated virus vaccines.


Daniel joined the department of infectious disease in 2022, where he is currently investigating how synonymous mutations in the genomes of viruses contribute to immune evasion. His research group uses synthetic virology approaches to study how coding biases in viruses affect virus replication and impact detection by the innate immune system. For more information, please visit the lab's website. Daniel has also been working with the Microbiology Society to promote and create more inclusive spaces for LGBTQ scientists in STEM. For more information, or if you'd like to get involved, please visit this website.

Key Publications

Rational attenuation of RNA viruses with zinc finger antiviral protein. Daniel Gonçalves-Carneiro, Emily Mastrocola, Xiao Lei, et al. (2022) Nature Microbiology. PMID: 36075961

Origin and evolution of the zinc finger antiviral protein. Daniel Gonçalves-Carneiro, Matthew A Takata, Heley Ong, et al. (2021) PLoS Pathogens. PMID: 33901262

Structure of the zinc-finger antiviral protein in complex with RNA reveals a mechanism for selective targeting of CG-rich viral sequences. Jennifer L Meagher, Matthew Takata, Daniel Gonçalves-Carneiro, et al. (2019) PNAS. PMID: 31719195

CG dinucleotide suppression enables antiviral defence targeting non-self RNA. Matthew A Takata, Daniel Gonçalves-Carneiro, Trinity M Zang, et al. (2017) Nature. PMID: 28953888