Imperial College London

Prof. Diana Gorog

Faculty of MedicineNational Heart & Lung Institute

Honorary Senior Research Fellow
 
 
 
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Contact

 

+44 (0)20 7034 8934d.gorog

 
 
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Location

 

Royal BromptonRoyal Brompton Campus

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Summary

 

Publications

Publication Type
Year
to

211 results found

Gorog DA, Gue YX, Chao T-F, Fauchier L, Ferreiro JL, Huber K, Konstantinidis SV, Lane DA, Marin F, Oldgren J, Potpara T, Roldan V, Rubboli A, Sibbing D, Tse H-F, Vilahur G, Lip GYHet al., 2022, Assessment and Mitigation of Bleeding Risk in Atrial Fibrillation and Venous Thromboembolism: Executive Summary of a European and Asia-Pacific Expert Consensus Paper, THROMBOSIS AND HAEMOSTASIS, ISSN: 0340-6245

Journal article

Gue YX, Gorog DA, Lip GYH, 2022, Antithrombotic Therapy in Atrial Fibrillation and Coronary Artery Disease Does Less Mean More?, JAMA CARDIOLOGY, ISSN: 2380-6583

Journal article

Kanji R, Gue YX, Saw AM, Shahid MQ, Gorog DAet al., 2022, Does targeted temperature management increase the risk of stent thrombosis in survivors of out-of-hospital cardiac arrest? A single centre experience, Publisher: OXFORD UNIV PRESS, ISSN: 0008-6363

Conference paper

Vandenbriele C, Arachchillage DJ, Frederiks P, Giustino G, Gorog DA, Gramegna M, Janssens S, Meyns B, Polzin A, Scandroglio M, Schrage B, Stone GW, Tavazzi G, Vanassche T, Vranckx P, Westermann D, Price S, Chieffo Aet al., 2022, Anticoagulation for percutaneous ventricular assist device-supported cardiogenic shock, Journal of the American College of Cardiology, Vol: 79, Pages: 1949-1962, ISSN: 0735-1097

Interest in the use of mechanical circulatory support for patients presenting with cardiogenic shock is growing rapidly. The Impella (Abiomed Inc), a microaxial, continuous-flow, short-term, ventricular assist device (VAD), requires meticulous postimplantation management. Because systemic anticoagulation is needed to prevent pump thrombosis, patients are exposed to increased bleeding risk, further aggravated by sepsis, thrombocytopenia, and high shear stress–induced acquired von Willebrand syndrome. The precarious balance between bleeding and thrombosis in percutaneous VAD–supported cardiogenic shock patients is often the main reason that patient outcomes are jeopardized, and there is a lack of data addressing optimal anticoagulation management strategies during percutaneous VAD support. Here, we present a parallel anti-Factor Xa/activated partial thromboplastin time-guided anticoagulation algorithm and discuss pitfalls of heparin monitoring in critically ill patients. This review will guide physicians toward a more standardized (anti)coagulation approach to tackle device-related morbidity and mortality in this critically ill patient group.

Journal article

Piccini JP, Caso V, Connolly SJ, Fox KAA, Oldgren J, Jones WS, Gorog DA, Durdil V, Viethen T, Neumann C, Mundl H, Patel MRet al., 2022, Safety of the oral factor XIa inhibitor asundexian compared with apixaban in patients with atrial fibrillation (PACIFIC-AF): a multicentre, randomised, double-blind, double-dummy, dose-finding phase 2 study, LANCET, Vol: 399, Pages: 1383-1390, ISSN: 0140-6736

Journal article

Gorog DA, Gue YX, Chao T-F, Fauchier L, Ferreiro JL, Huber K, Konstantinidis S, Lane DA, Marin F, Oldgren J, Potpara T, Roldan V, Rubboli A, Sibbing D, Tse H-F, Vilahur G, Lip GYHet al., 2022, Assessment and mitigation of bleeding risk in atrial fibrillation and venous thromboembolism: A Position Paper from the ESC Working Group on Thrombosis, in collaboration with the European Heart Rhythm Association, the Association for Acute CardioVascular Care and the Asia-Pacific Heart Rhythm Society, EUROPACE, ISSN: 1099-5129

Journal article

Gorog DA, Storey RF, Gurbel PA, Tantry US, Berger JS, Chan MY, Duerschmied D, Smyth SS, Parker WAE, Ajjan RA, Vilahur G, Badimon L, ten Berg JM, ten Cate H, Peyvandi F, Wang TT, Becker RCet al., 2022, Current and novel biomarkers of thrombotic risk in COVID-19: a Consensus Statement from the International COVID-19 Thrombosis Biomarkers Colloquium, NATURE REVIEWS CARDIOLOGY, Vol: 19, Pages: 475-495, ISSN: 1759-5002

Journal article

Kubica J, Adamski P, Gorog DA, Kubica A, Jilma B, Budaj A, Siller-Matula JM, Gurbel PA, Alexopoulos D, Badariene J, Dabrowski P, Dudek D, Giannitsis E, Horszczaruk G, Jaguszewski MJ, James S, Jeong Y-H, Kryjak M, Niezgoda P, Ostrowska M, Patti G, Romanek J, Di Somma S, Specchia G, Tantry U, Gasior M, Tycinska A, Wojakowski W, Buszko K, Gil R, Gruchala M, Kasprzak J, Kleinrok A, Legutko J, Lesiak M, Navarese EPet al., 2022, Low-dose ticagrelor with or without acetylsalicylic acid in patients with acute coronary syndrome: Rationale and design of the ELECTRA-SIRIO 2 trial, CARDIOLOGY JOURNAL, Vol: 29, Pages: 148-153, ISSN: 1897-5593

Journal article

Cenko E, Badimon L, Bugiardini R, Claeys MJ, De Luca G, de Wit C, Derumeaux G, Dorobantu M, Duncker DJ, Eringa EC, Gorog DA, Hassager C, Heinzel FR, Huber K, Manfrini O, Milicic D, Oikonomou E, Padro T, Trifunovic-Zamaklar D, Vasiljevic-Pokrajcic Z, Vavlukis M, Vilahur G, Tousoulis Det al., 2021, Cardiovascular disease and COVID-19: a consensus paper from the ESCWorking Group on Coronary Pathophysiology & Microcirculation, ESCWorking Group on Thrombosis and the Association for Acute CardioVascular Care (ACVC), in collaboration with the European Heart Rhythm Association (EHRA), CARDIOVASCULAR RESEARCH, Vol: 117, Pages: 2705-2729, ISSN: 0008-6363

Journal article

Becker RC, Gorog DA, 2021, International COVID-19 biomarkers colloquium, JOURNAL OF THROMBOSIS AND THROMBOLYSIS, Vol: 52, Pages: 983-984, ISSN: 0929-5305

Journal article

Singh S, Gorog DA, Mahon CF, Rawal B, Semple TR, Nicol ED, Arachchillage DRJ, Price S, Desai S, Ridge CA, Padley SPG, Mirsadraee Set al., 2021, Optimal Management of Thrombotic Complications in Patients With Coronavirus Disease 2019 Reply, CRITICAL CARE MEDICINE, Vol: 49, Pages: E1190-E1191, ISSN: 0090-3493

Journal article

Gorog DA, Yamamoto J, 2021, Global Thrombosis Test: Occlusion Is Attributable to Shear-Induced Platelet Thrombus Formation., TH Open, Vol: 5, Pages: e591-e597

Journal article

Gorog DA, Yamamoto J, 2021, Global Thrombosis Test: Occlusion Is Attributable to Shear-Induced Platelet Thrombus Formation, TH Open, Vol: 05, Pages: e591-e597

Journal article

Gorog DA, Navarese EP, Andreotti F, 2021, Should we consider low LDL-cholesterol a marker of in-hospital bleeding in patients with acute coronary syndrome undergoing percutaneous coronary intervention?, EUROPEAN HEART JOURNAL, Vol: 42, Pages: 3187-3189, ISSN: 0195-668X

Journal article

Jasiewicz M, Siedlaczek M, Kasprzak M, Gorog DA, Jilma B, Siller-Matula J, Obońska K, Dobosiewicz R, Pstrągowski K, Kubica Jet al., 2021, Elevated serum transaminases in patients with acute coronary syndromes: Do we need a revision of exclusion criteria for clinical trials?, Cardiol J

BACKGROUND: Elevations of hepatic transaminase (serum alanine transaminase [ALT] and serum aspartate aminotransferase [AST]) levels in patients with acute coronary syndrome (ACS), although transient, may result in exclusions from clinical efficacy trials due to suspected liver disease. The aim of this study was to evaluate the concentrations of serum transaminases in ACS and relate these to currently accepted AST/ALT exclusion criteria from clinical trials. METHODS: 100 consecutive patients with ACS were prospectively examined. Blood samples for AST, ALT, total bilirubin and troponin I concentration were obtained at the time of admission and after 6, 12 and 24 hours. RESULTS: Eighty percent of patients had elevated AST, and 47% ALT; 43% of patients characterized AST concentration > 3 × upper limit of normal (ULN) in at least one measurement, while 8% of patients presented ALT concentration > 3 × ULN. AST presented higher concentrations when compared to ALT, resulting in a high De-Ritis ratio at every time point. No significant or high correlations were found between the concentrations of serum transaminases, De-Ritis ratio and troponin I. Two different cut-off values of troponin I were adopted to define the amount of infarcted myocardium that distinguished 28-31% of individuals with "large infarction". Among these patients, approximately 93% presented AST concentrations > 3 × ULN. CONCLUSIONS: Hepatic transaminases are often elevated in ACS, with the majority of patients with more extensive myocardial injury presenting high concentrations of AST. In the setting of ACS, current transaminase thresholds for liver dysfunction used in clinical trials may lead to excessive and inadequate exclusions of patients with larger infarcts from such trials.

Journal article

Farag M, Kiberu Y, Reddy SA, Shoaib A, Egred M, Krishnan U, Fares M, Peverelli M, Gorog DA, Elmahdy W, Berman M, Osman Met al., 2021, Preoperative Atrial Fibrillation is associated with long-term morTality in patients undergoing suRgical AortiC valvE Replacement, JOURNAL OF CARDIAC SURGERY, Vol: 36, Pages: 3561-3566, ISSN: 0886-0440

Journal article

Navarese EP, Kereiakes DJ, Gorog DA, Lansky AJ, Andreotti Fet al., 2021, When a meta-analysis equals a single large-scale trial with meaningful follow-up, EUROPEAN HEART JOURNAL, Vol: 42, Pages: 3884-3885, ISSN: 0195-668X

Journal article

Farag M, Peverelli M, Spinthakis N, Gue YX, Egred M, Gorog DAet al., 2021, Spontaneous Reperfusion in Patients with Transient ST-Elevation Myocardial Infarction-Prevalence, Importance and Approaches to Management, CARDIOVASCULAR DRUGS AND THERAPY, ISSN: 0920-3206

Journal article

Davidson SM, Lukhna K, Gorog DA, Salama AD, Castillo AR, Giesz S, Golforoush P, Kalkhoran SB, Lecour S, Imamdin A, do Carmo HRP, Bovi TG, Perroud MW, Ntsekhe M, Sposito AC, Yellon DMet al., 2021, RIC in COVID-19-a Clinical Trial to Investigate Whether Remote Ischemic Conditioning (RIC) Can Prevent Deterioration to Critical Care in Patients with COVID-19 (Jun, 10.1007/s10557-021-07221-y, 2021), CARDIOVASCULAR DRUGS AND THERAPY, ISSN: 0920-3206

Journal article

Kubica J, Adamski P, Niezgoda P, Kubica A, Podhajski P, Baranska M, Uminska JM, Pietrzykowski L, Ostrowska M, Siller-Matula JM, Badariene J, Bartus S, Budaj A, Dobrzycki S, Fidor L, Gasior M, Gessek J, Gierlotka M, Gil R, Goracy J, Grzelakowski P, Hajdukiewicz T, Jaguszewski M, Janion M, Kasprzak J, Kern A, Klecha A, Kleinrok A, Kochman W, Krakowiak B, Legutko J, Lesiak M, Nosal M, Piotrowski G, Przybylski A, Roleder T, Skonieczny G, Sobieszek G, Tycinska A, Wojciechowski D, Wojakowski W, Wojcik J, Zielinska M, Zurakowski A, Specchia G, Gorog DA, Navarese EPet al., 2021, A new approach to ticagrelor-based de-escalation of antiplatelet therapy after acute coronary syndrome. A rationale for a randomized, double-blind, placebo-controlled, investigator-initiated, multicenter clinical study, CARDIOLOGY JOURNAL, Vol: 28, Pages: 607-614, ISSN: 1897-5593

Journal article

Davidson SM, Lukhna K, Gorog DA, Salama AD, Castillo AR, Giesz S, Golforoush P, Kalkhoran SB, Lecour S, Imamdin A, do Carmo HRP, Bovi TG, Perroud MW, Ntsekhe M, Sposito AC, Yellon DMet al., 2021, RIC in COVID-19-a Clinical Trial to Investigate Whether Remote Ischemic Conditioning (RIC) Can Prevent Deterioration to Critical Care in Patients with COVID-19, CARDIOVASCULAR DRUGS AND THERAPY, ISSN: 0920-3206

Journal article

Bhatt DL, Kaski JC, Delaney S, Alasnag M, Andreotti F, Angiolillo DJ, Ferro A, Gorog DA, Lorenzatti AJ, Mamas M, McNeil J, Nicolau JC, Steg PG, Tamargo J, Tan D, Valgimigli Met al., 2021, Results of an international crowdsourcing survey on the treatment of non-ST segment elevation ACS patients at high-bleeding risk undergoing percutaneous intervention, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 337, Pages: 1-8, ISSN: 0167-5273

Journal article

Jenner WJ, Gorog DA, 2021, Incidence of thrombotic complications in COVID-19 On behalf of ICODE: The International COVID-19 Thrombosis Biomarkers Colloquium, JOURNAL OF THROMBOSIS AND THROMBOLYSIS, Vol: 52, Pages: 999-1006, ISSN: 0929-5305

Journal article

Vandenbriele C, Gorog DA, 2021, Screening for venous thromboembolism in patients with COVID-19, JOURNAL OF THROMBOSIS AND THROMBOLYSIS, Vol: 52, Pages: 985-991, ISSN: 0929-5305

Journal article

Navarese EP, Lansky AJ, Kereiakes DJ, Kubica J, Gurbel PA, Gorog DA, Valgimigli M, Curzen N, Kandzari DE, Bonaca MP, Brouwer M, Uminska J, Jaguszewski MJ, Raggi P, Waksman R, Leon MB, Wijns W, Andreotti Fet al., 2021, Cardiac mortality in patients randomised to elective coronary revascularisation plus medical therapy or medical therapy alone: a systematic review and meta-analysis, EUROPEAN HEART JOURNAL, Vol: 42, Pages: 4638-4651, ISSN: 0195-668X

Journal article

Kanji R, Vandenbriele C, Arachchillage DRJ, Price S, Gorog DAet al., 2021, Optimal Tests to Minimise Bleeding and Ischaemic Complications in Patients on Extracorporeal Membrane Oxygenation, THROMBOSIS AND HAEMOSTASIS, Vol: 122, Pages: 480-491, ISSN: 0340-6245

Journal article

Kanji R, Gue YX, Memtsas V, Gorog DAet al., 2021, Fibrinolysis in Platelet Thrombi, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, Vol: 22

Journal article

Gue YX, Ding WY, Lip GYH, Gorog DAet al., 2021, Assessment of endogenous fibrinolysis in clinical practice using novel tests: ready for clinical roll-out?, SN APPLIED SCIENCES, Vol: 3, ISSN: 2523-3963

Journal article

Mirsadraee S, Gorog DA, Mahon CF, Rawal B, Semple TR, Nicol ED, Arachchillage DRJ, Devaraj A, Price S, Desai SR, Ridge CA, Singh S, Padley SPGet al., 2021, Prevalence of Thrombotic Complications in ICU-Treated Patients With Coronavirus Disease 2019 Detected With Systematic CT Scanning, CRITICAL CARE MEDICINE, Vol: 49, Pages: 804-815, ISSN: 0090-3493

Journal article

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