Publications
282 results found
Costopoulos C, Gorog DA, Di Mario C, et al., 2013, Use of thrombectomy devices in primary percutaneous coronary intervention: A systematic review and meta-analysis, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 163, Pages: 229-241, ISSN: 0167-5273
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- Citations: 36
Sharma S, Farrington K, Kozarski R, et al., 2013, Impaired thrombolysis: a novel cardiovascular risk factor in end-stage renal disease, EUROPEAN HEART JOURNAL, Vol: 34, Pages: 354-+, ISSN: 0195-668X
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- Citations: 37
Sharma S, Sandler B, Cristopoulos C, et al., 2012, Temporary transvenous pacing: endangered skill, EMERGENCY MEDICINE JOURNAL, Vol: 29, Pages: 926-927, ISSN: 1472-0205
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- Citations: 8
Niespialowska-Steuden MM, Markides V, Gorog DA, 2012, Novel antithrombotic agents for atrial fibrillation, PHARMACOLOGY & THERAPEUTICS, Vol: 134, Pages: 345-354, ISSN: 0163-7258
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- Citations: 2
Morrow DA, Braunwald E, Bonaca MP, et al., 2012, Vorapaxar in the Secondary Prevention of Atherothrombotic Events, NEW ENGLAND JOURNAL OF MEDICINE, Vol: 366, Pages: 1404-1413, ISSN: 0028-4793
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- Citations: 712
Gorog DA, Yamamoto J, Saraf S, et al., 2011, First direct comparison of platelet reactivity and thrombolytic status between Japanese and Western volunteers: Possible relationship to the "Japanese paradox", INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 152, Pages: 43-48, ISSN: 0167-5273
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- Citations: 44
Sharma S, Christopoulos C, Kukreja N, et al., 2011, Local drug delivery for percutaneous coronary intervention, PHARMACOLOGY & THERAPEUTICS, Vol: 129, Pages: 260-266, ISSN: 0163-7258
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- Citations: 22
Sharma S, Moffat D, Gorog DA, 2010, Coronary spasm: an unusual cause of ST elevation., BMJ Case Rep, Vol: 2010
Kumar S, Gorog DA, Secco GG, et al., 2010, The Guide Liner "Child" Catheter for Percutaneous Coronary Intervention - Early Clinical Experience, JOURNAL OF INVASIVE CARDIOLOGY, Vol: 22, Pages: 495-498, ISSN: 1042-3931
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- Citations: 35
Sharma S, Moffat D, Christopoulous C, et al., 2010, Global thrombotic status predicts cardiovascular events in end-stage renal failure, ESC Congress, Publisher: OXFORD UNIV PRESS, Pages: 971-971, ISSN: 0195-668X
Sharma S, Kukreja N, Christopoulos C, et al., 2010, Erratum: Drug-eluting balloon: New tool in the box (Expert Review of Medical Devices (2010) 7:3 (381-388)), Expert Review of Medical Devices, Vol: 7, ISSN: 1743-4440
Sharma S, Kukreja N, Christopoulos C, et al., 2010, Drug-eluting balloon: new tool in the box (vol 7, pg 381, 2010), EXPERT REVIEW OF MEDICAL DEVICES, Vol: 7, Pages: 576-576, ISSN: 1743-4440
Gorog DA, 2010, Prognostic Value of Plasma Fibrinolysis Activation Markers in Cardiovascular Disease, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 55, Pages: 2701-2709, ISSN: 0735-1097
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- Citations: 92
Rao U, Gorog D, Syzgula J, et al., 2010, The GuideLiner™ "child" catheter, EUROINTERVENTION, Vol: 6, Pages: 277-279, ISSN: 1774-024X
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- Citations: 18
Saraf S, Christopoulos C, Ben Salha I, et al., 2010, Impaired Endogenous Thrombolysis in Acute Coronary Syndrome Patients Predicts Cardiovascular Death and Nonfatal Myocardial Infarction, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 55, Pages: 2107-2115, ISSN: 0735-1097
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- Citations: 57
Sharma S, Kukreja N, Christopoulos C, et al., 2010, Drug-eluting balloon: new tool in the box, EXPERT REVIEW OF MEDICAL DEVICES, Vol: 7, Pages: 381-388, ISSN: 1743-4440
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- Citations: 21
Duhot D, McGregor E, Gorog D, et al., 2010, An international perspective on cardiovascular risk management: Recommendations for high-risk patients, Primary Care Cardiovascular Journal, Vol: 3, Pages: 91-96, ISSN: 1756-5138
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- Citations: 1
Jones DG, Wong T, Gorog D, et al., 2010, Atrial fibrillation: which patients should be managed in primary, secondary and tertiary care?, Primary Care Cardiovascular Journal (PCCJ), Vol: 3, Pages: 19-31, ISSN: 1756-5138
Saraf S, Bensalha I, Gorog DA, 2009, Antiplatelet Resistance-Does it Exist and How to Measure it?, Clin Med Cardiol, Vol: 3, Pages: 77-91
Aspirin and clopidogrel are the most commonly used antiplatelet agents in patients with coronary artery disease. The existence of resistance to these agents has been a controversial issue and new drugs are being developed to overcome this problem. Laboratory tests, which can identify resistance and correlate this with clinical outcome, are being studied in order to identify patients at risk of future thrombotic events. We discuss the evidence for the existence of antiplatelet resistance-both in the laboratory and in the clinical setting. So far, platelet aggregometry has been considered the gold standard test, but is very operator dependant, time consuming, and has shown little correlation with other available tests of antiplatelet resistance. We discuss the available tests of platelet function, their limitations, and evidence for their use. A simple, rapid, near-patient test, which is affordable and useful in the clinical (not just laboratory) setting, could allow risk stratification of patients and individualization of antiplatelet medication to improve outcome.
Gorog DA, Jabr RI, Tanno M, et al., 2009, MAPKAPK-2 modulates p38-MAPK localization and small heat shock protein phosphorylation but does not mediate the injury associated with p38-MAPK activation during myocardial ischemia, CELL STRESS & CHAPERONES, Vol: 14, Pages: 477-489, ISSN: 1355-8145
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- Citations: 16
Saraf S, Wellsted D, Sharma S, et al., 2009, Shear-induced global thrombosis test of native blood: Pivotal role of ADP allows monitoring of P2Y12 antagonist therapy, THROMBOSIS RESEARCH, Vol: 124, Pages: 447-451, ISSN: 0049-3848
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- Citations: 13
Gorog DA, Sweeny JM, Fuster V, 2009, Antiplatelet drug 'resistance'. Part 2: laboratory resistance to antiplatelet drugs-fact or artifact?, NATURE REVIEWS CARDIOLOGY, Vol: 6, Pages: 365-373, ISSN: 1759-5002
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- Citations: 47
Sweeny JM, Gorog DA, Fuster V, 2009, Antiplatelet drug 'resistance'. Part 1: mechanisms and clinical measurements, NATURE REVIEWS CARDIOLOGY, Vol: 6, Pages: 273-282, ISSN: 1759-5002
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- Citations: 81
Saraf S, Sharma S, Ben Salha I, et al., 2009, Impaired Endogenous Thrombolysis: A Novel Predictor of Recurrent Cardiovascular Events in Patients With Acute Coronary Syndrome, 58th Annual Scientific Session of the American-College-of-Cardiology, Publisher: ELSEVIER SCIENCE INC, Pages: A439-A439, ISSN: 0735-1097
Saraf S, Ishii H, Yamamoto J, et al., 2009, Marked Differences in Thrombotic and Thrombolytic Status Between Japanese and Western Subjects, 58th Annual Scientific Session of the American-College-of-Cardiology, Publisher: ELSEVIER SCIENCE INC, Pages: A421-A421, ISSN: 0735-1097
Saraf S, Sharma S, Ben Salha I, et al., 2009, Clopidogrel Resistance as Assessed by P2Y(12) Receptor Inhibition Is Not Reflective of Global Thrombotic Status, 58th Annual Scientific Session of the American-College-of-Cardiology, Publisher: ELSEVIER SCIENCE INC, Pages: A422-A422, ISSN: 0735-1097
Saraf S, Gorog D, 2009, When is coronary revascularisation superior to medical therapy in patients with angina?, Primary Care Cardiovascular Journal, Vol: 2, Pages: 25-30, ISSN: 1756-5138
Gorog DA, Saraf S, Markides V, 2009, Coronary thrombosis: In vivo, ex vivo and in vitro., BMJ Case Rep, Vol: 2009
Acute stent thrombosis remains one of the most important concerns in clinical cardiology. The mechanism is not fully understood but a prothrombotic state is a key component. We describe a case of acute stent thrombosis, within an hour of rescue angioplasty, despite use of full dose fibrinolytic (reteplase) and antiplatelet therapy (aspirin and clopidogrel). Risk of acute stent thrombosis was predicted an hour earlier, when the patient was clinically well, by a novel near-patient test of thrombotic and thrombolytic status (in vitro). Subsequent stent thrombosis was visualised angiographically (in vivo) and confirmed by extraction of the thrombus (ex vivo). The near-patient test sensitively detected reversal of the prothrombotic state after abciximab treatment. We believe this is the first description of the clinical use of a near-patient test within the cardiac catheterisation laboratory to predict risk of imminent stent thrombosis.
Ball MJ, Keenan N, Lynch M, et al., 2009, Identifying the aetiology of left ventricular hypertrophy in an athlete: importance of lifestyle modification., BMJ Case Rep, Vol: 2009
The aetiology of left ventricular hypertrophy (LVH) in an athlete is often difficult to identify. We describe a 29-year-old fitness instructor who was referred for investigation of syncope. He gave a history of intensive weight lifting and anabolic steroid use at supra-therapeutic doses for the preceding 6 years. Electrocardiography showed inferolateral repolarisation abnormalities and a transthoracic echocardiogram demonstrated asymmetrical LVH with reduced left ventricular cavity dimensions. There was no left ventricular outflow tract obstruction or systolic motion of the anterior mitral valve leaflet. These findings were confirmed on cardiac magnetic resonance imaging (CMR). The differential diagnosis included athlete's heart, steroid-induced cardiomyopathy and non-obstructive hypertrophic cardiomyopathy. The patient was advised to discontinue both steroid use and intensive training. After 3 years of steroid abstinence but continued training, the syncopal episodes and the ECG abnormalities completely resolved, associated with regression of LVH on echocardiography and CMR.
Gorog DA, Saraf S, Ben Salha I, et al., 2008, Measurement of clopidogrel resistance by ADP-inhibition does not reflect the benefit of clopidogrel on overall thrombotic status, 57th Annual Scientific Session of the American-College-of-Cardiology, Publisher: ELSEVIER SCIENCE INC, Pages: A335-A335, ISSN: 0735-1097
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- Citations: 2
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