Imperial College London
Alternate

DrDavidHodson

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Honorary Senior Lecturer (non-clinical)
 
 
 
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Contact

 

+44 (0)20 7594 1713d.hodson Website

 
 
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Location

 

329ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Janjuha:2018:10.7554/eLife.32965,
author = {Janjuha, S and Singh, SP and Tsakmaki, A and Mousavy, Gharavy NS and Murawala, P and Konantz, J and Birke, S and Hodson, DJ and Rutter, GA and Bewick, GA},
doi = {10.7554/eLife.32965},
journal = {eLife},
title = {Age-related islet inflammation marks the proliferative decline of pancreatic beta-cells in zebrafish},
url = {http://dx.doi.org/10.7554/eLife.32965},
volume = {7},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The pancreatic islet, a cellular community harboring the insulin-producing beta-cells, is known to undergo age-related alterations. However, only a handful of signals associated with aging have been identified. By comparing beta-cells from younger and older zebrafish, here we show that the aging islets exhibit signs of chronic inflammation. These include recruitment of tnfα-expressing macrophages and the activation of NF-kB signaling in beta-cells. Using a transgenic reporter, we show that NF-kB activity is undetectable in juvenile beta-cells, whereas cells from older fish exhibit heterogeneous NF-kB activity. We link this heterogeneity to differences in gene expression and proliferation. Beta-cells with high NF-kB signaling proliferate significantly less compared to their neighbors with low activity. The NF-kB signalinghi cells also exhibit premature upregulation of socs2, an age-related gene that inhibits beta-cell proliferation. Together, our results show that NF-kB activity marks the asynchronous decline in beta-cell proliferation with advancing age.
AU  - Janjuha,S
AU  - Singh,SP
AU  - Tsakmaki,A
AU  - Mousavy,Gharavy NS
AU  - Murawala,P
AU  - Konantz,J
AU  - Birke,S
AU  - Hodson,DJ
AU  - Rutter,GA
AU  - Bewick,GA
DO  - 10.7554/eLife.32965
PY  - 2018///
SN  - 2050-084X
TI  - Age-related islet inflammation marks the proliferative decline of pancreatic beta-cells in zebrafish
T2  - eLife
UR  - http://dx.doi.org/10.7554/eLife.32965
UR  - http://hdl.handle.net/10044/1/58916
VL  - 7
ER  -
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