Imperial College London
Alternate

ProfessorDavidHolden

Faculty of Medicine, Department of Infectious Disease

Professor
 
 
 
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Contact

 

+44 (0)20 7594 3073d.holden

 
 
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Location

 

221Flowers buildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Cerny:2019:10.1016/j.imlet.2019.01.006,
author = {Cerny, O and Holden, D},
doi = {10.1016/j.imlet.2019.01.006},
journal = {Immunology Letters},
pages = {35--39},
title = {Salmonella SPI-2 type III secretion system-dependent inhibition of antigen presentation and T cell function},
url = {http://dx.doi.org/10.1016/j.imlet.2019.01.006},
volume = {215},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Salmonella enterica serovars infect a broad range of mammalian hosts, including humans, causing both gastrointestinal and systemic diseases. Effective immune responses to Salmonella infections depend largely on CD4+ T cell activation by dendritic cells (DCs). Bacteria are internalised by intestinal DCs and respond by translocating effectors of the Salmonella pathogenicity island 2 (SPI-2) type III secretion system (T3SS) into host cells. In this review, we discuss processes that are hijacked by SPI-2 T3SS effectors and how this affects DC biology and the activation of T cell responses.
AU  - Cerny,O
AU  - Holden,D
DO  - 10.1016/j.imlet.2019.01.006
EP  - 39
PY  - 2019///
SN  - 0165-2478
SP  - 35
TI  - Salmonella SPI-2 type III secretion system-dependent inhibition of antigen presentation and T cell function
T2  - Immunology Letters
UR  - http://dx.doi.org/10.1016/j.imlet.2019.01.006
UR  - http://hdl.handle.net/10044/1/67103
VL  - 215
ER  -
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