Imperial College London
Alternate

Professor Deirdre Hollingsworth

Faculty of Medicine, School of Public Health

Honorary Lecturer
 
 
 
//

Contact

 

d.hollingsworth Website

 
 
//

Location

 

Norfolk PlaceSt Mary's Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Spencer:2021:10.12688/gatesopenres.13261.1,
author = {Spencer, SEF and Laeyendecker, O and Dyson, L and Hsieh, Y-H and Patel, EU and Rothman, RE and Kelen, GD and Quinn, TC and Hollingsworth, TD},
doi = {10.12688/gatesopenres.13261.1},
journal = {Gates Open Research},
pages = {116--116},
title = {Estimating HIV, HCV and HSV2 incidence from emergency department serosurvey},
url = {http://dx.doi.org/10.12688/gatesopenres.13261.1},
volume = {5},
year = {2021}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - <ns4:p><ns4:bold>Background: </ns4:bold>Our understanding of pathogens and disease transmission has improved dramatically over the past 100 years, but coinfection, how different pathogens interact with each other, remains a challenge. Cross-sectional serological studies including multiple pathogens offer a crucial insight into this problem. </ns4:p><ns4:p> <ns4:bold>Methods: </ns4:bold>We use data from three cross-sectional serological surveys (in 2003, 2007 and 2013) in a Baltimore emergency department to predict the prevalence for HIV, hepatitis C virus (HCV) and herpes simplex virus, type 2 (HSV2), in a fourth survey (in 2016). We develop a mathematical model to make this prediction and to estimate the incidence of infection and coinfection in each age and ethnic group in each year.</ns4:p><ns4:p> <ns4:bold>Results: </ns4:bold>Overall we find a much stronger age cohort effect than a time effect, so that, while incidence at a given age may decrease over time, individuals born at similar times experience a more constant force of infection over time.</ns4:p><ns4:p> <ns4:bold>Conclusions: </ns4:bold>These results emphasise the importance of age-cohort counselling and early intervention while people are young. Our approach adds value to data such as these by providing age- and time-specific incidence estimates which could not be obtained any other way, and allows forecasting to enable future public health planning.</ns4:p>
AU  - Spencer,SEF
AU  - Laeyendecker,O
AU  - Dyson,L
AU  - Hsieh,Y-H
AU  - Patel,EU
AU  - Rothman,RE
AU  - Kelen,GD
AU  - Quinn,TC
AU  - Hollingsworth,TD
DO  - 10.12688/gatesopenres.13261.1
EP  - 116
PY  - 2021///
SP  - 116
TI  - Estimating HIV, HCV and HSV2 incidence from emergency department serosurvey
T2  - Gates Open Research
UR  - http://dx.doi.org/10.12688/gatesopenres.13261.1
VL  - 5
ER  -
Download