Imperial College London
Alternate

ProfessorDebbieJarvis

Faculty of Medicine, National Heart & Lung Institute

Professor of Public Health
 
 
 
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Contact

 

+44 (0)20 7594 7944d.jarvis

 
 
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Assistant

 

Ms Hilary Barton +44 (0)20 7594 7942

 
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Location

 

28Emmanuel Kaye BuildingRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Emilsson:2020:10.1007/s11325-020-02086-1,
author = {Emilsson, OI and Sundbom, F and Ljunggren, M and Benediktsdottir, B and Garcia-Aymerich, J and Bui, DS and Jarvis, D and Olin, A-C and Franklin, KA and Demoly, P and Lindberg, E and Janson, C and Aspelund, T and Gislason, T},
doi = {10.1007/s11325-020-02086-1},
journal = {Sleep and Breathing: international journal of the science and practice of sleep medicine},
pages = {587--596},
title = {Association between lung function decline and obstructive sleep apnoea: the ALEC study},
url = {http://dx.doi.org/10.1007/s11325-020-02086-1},
volume = {25},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - PurposeTo study changes in lung function among individuals with a risk of obstructive sleep apnoea (OSA), and if asthma affected this relationship.MethodsWe used data from the European Community Respiratory Health Survey II and III, a multicentre general population study. Participants answered questionnaires and performed spirometry at baseline and 10-year follow-up (n = 4,329 attended both visits). Subjects with high risk for OSA were identified from the multivariable apnoea prediction (MAP) index, calculated from BMI, age, gender, and OSA symptoms at follow-up. Asthma was defined as having doctor’s diagnosed asthma at follow-up. Primary outcomes were changes in forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) from baseline to follow-up.ResultsAmong 5108 participants at follow-up, 991 (19%) had a high risk of OSA based on the MAP index. Participants with high OSA risk more often had wheeze, cough, chest tightness, and breathlessness at follow-up than those with low OSA risk. Lung function declined more rapidly in subjects with high OSA risk (low vs high OSA risk [mean ± SD]: FEV1 = − 41.3 ± 24.3 ml/year vs − 50.8 ± 30.1 ml/year; FVC = − 30.5 ± 31.2 ml/year vs − 45.2 ± 36.3 ml/year). Lung function decline was primarily associated with higher BMI and OSA symptoms. OSA symptoms had a stronger association with lung function decline among asthmatics, compared to non-asthmatics.ConclusionIn the general population, a high probability of obstructive sleep apnoea was related to faster lung function decline in the previous decade. This was driven by a higher BMI and more OSA symptoms among these subjects. The association between OSA symptoms and lung function decline was stronger among asthmatics.
AU  - Emilsson,OI
AU  - Sundbom,F
AU  - Ljunggren,M
AU  - Benediktsdottir,B
AU  - Garcia-Aymerich,J
AU  - Bui,DS
AU  - Jarvis,D
AU  - Olin,A-C
AU  - Franklin,KA
AU  - Demoly,P
AU  - Lindberg,E
AU  - Janson,C
AU  - Aspelund,T
AU  - Gislason,T
DO  - 10.1007/s11325-020-02086-1
EP  - 596
PY  - 2020///
SN  - 1520-9512
SP  - 587
TI  - Association between lung function decline and obstructive sleep apnoea: the ALEC study
T2  - Sleep and Breathing: international journal of the science and practice of sleep medicine
UR  - http://dx.doi.org/10.1007/s11325-020-02086-1
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000545929200001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://link.springer.com/article/10.1007%2Fs11325-020-02086-1
UR  - http://hdl.handle.net/10044/1/82729
VL  - 25
ER  -
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