Imperial College London
Alternate

ProfessorDebbieJarvis

Faculty of Medicine, National Heart & Lung Institute

Professor of Public Health
 
 
 
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Contact

 

+44 (0)20 7594 7944d.jarvis

 
 
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Assistant

 

Ms Hilary Barton +44 (0)20 7594 7942

 
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Location

 

28Emmanuel Kaye BuildingRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Weber:2020:10.1183/23120541.00065-2020,
author = {Weber, P and Menezes, AMB and Gonçalves, H and Perez-Padilla, R and Jarvis, D and de, Oliveira PD and Wehrmeister, FC},
doi = {10.1183/23120541.00065-2020},
journal = {ERJ Open Research},
title = {Characterisation of pulmonary function trajectories: results from a Brazilian cohort.},
url = {http://dx.doi.org/10.1183/23120541.00065-2020},
volume = {6},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background: Pulmonary function (PF) trajectories are determined by different exposures throughout the life course. The aim of this study was to investigate characteristics related to PF trajectories from 15 to 22years in a Brazilian cohort. Methods: A birth cohort study (1993 Pelotas Birth Cohort) was conducted with spirometry at 15, 18 and 22years. PF trajectories were built based on z-score of forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and their ratio using a group-based trajectory model. Associations with exposures reported from perinatal to 22years were described. Results: Three trajectories, low (LT), average (AT) and high (HT) were identified in 2917 individuals. Wealthiest individuals belonged to the HT of FEV1 (p=0.023). Lower maternal pregestational body mass index (BMI) (22.4±0.2; p<0.001 and 22.1±0.14; p<0.001) and lower birth weight (3164.8±25.4; p=0.029 and 3132.3±19.4; p=0.005) were related to the LT of FEV1 and FVC. Mother's smoking exposure during pregnancy (37.7%; p=0.002), active smoking at ages 18 and 22 years (20.1% and 25.8%; p<0.001) and family history of asthma (44.8%; p<0.001) were related to the LT of FEV1/FVC. Wheezing, asthma and hospitalisations due to respiratory diseases in childhood were related to the LT of both FEV1 and FEV1/FVC. Higher BMIs were related to the HT of FEV1 and FVC at all ages. Conclusions: PF trajectories were mainly related to income, pregestational BMI, birth weight, hospitalisation due to respiratory diseases in childhood, participant's BMI, report of wheezing, medical diagnosis and family history of asthma, gestational exposure to tobacco and current smoking status in adolescence and young adult age.
AU  - Weber,P
AU  - Menezes,AMB
AU  - Gonçalves,H
AU  - Perez-Padilla,R
AU  - Jarvis,D
AU  - de,Oliveira PD
AU  - Wehrmeister,FC
DO  - 10.1183/23120541.00065-2020
PY  - 2020///
SN  - 2312-0541
TI  - Characterisation of pulmonary function trajectories: results from a Brazilian cohort.
T2  - ERJ Open Research
UR  - http://dx.doi.org/10.1183/23120541.00065-2020
UR  - https://www.ncbi.nlm.nih.gov/pubmed/32864380
UR  - http://hdl.handle.net/10044/1/82281
VL  - 6
ER  -
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