Imperial College London
Alternate

ProfessorDebbieJarvis

Faculty of Medicine, National Heart & Lung Institute

Professor of Public Health
 
 
 
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Contact

 

+44 (0)20 7594 7944d.jarvis

 
 
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Assistant

 

Ms Hilary Barton +44 (0)20 7594 7942

 
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Location

 

28Emmanuel Kaye BuildingRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Wielscher:2021:10.1186/s13073-021-00914-x,
author = {Wielscher, M and Amaral, AFS and van, der Plaat D and Wain, LV and Sebert, S and Mosen-Ansorena, D and Auvinen, J and Herzig, K-H and Dehghan, A and Jarvis, DL and Jarvelin, M-R},
doi = {10.1186/s13073-021-00914-x},
journal = {Genome Medicine},
title = {Genetic correlation and causal relationships between cardio-metabolic traits and lung function impairment},
url = {http://dx.doi.org/10.1186/s13073-021-00914-x},
volume = {13},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - <jats:title>Abstract</jats:title><jats:sec>                <jats:title>Background</jats:title>                <jats:p>Associations of low lung function with features of poor cardio-metabolic health have been reported. It is, however, unclear whether these co-morbidities reflect causal associations, shared genetic heritability or are confounded by environmental factors.</jats:p>              </jats:sec><jats:sec>                <jats:title>Methods</jats:title>                <jats:p>We performed three analyses: (1) cardio-metabolic health to lung function association tests in Northern Finland Birth cohort 1966, (2) cross-trait linkage disequilibrium score regression (LDSC) to compare genetic backgrounds and (3) Mendelian randomisation (MR) analysis to assess the causal effect of cardio-metabolic traits and disease on lung function, and vice versa (bidirectional MR). Genetic associations were obtained from the UK Biobank data or published large-scale genome-wide association studies (<jats:italic>N</jats:italic> > 82,000).</jats:p>              </jats:sec><jats:sec>                <jats:title>Results</jats:title>                <jats:p>We observed a negative genetic correlation between lung function and cardio-metabolic traits and diseases. In Mendelian Randomisation analysis (MR), we found associations between type 2 diabetes (T2D) instruments and forced vital capacity (FVC) as well as FEV1/FVC. Body mass index (BMI) instruments were associated to all lung function traits and C-reactive protein (CRP) instruments to FVC. These genetic associations provide evidence for a causal effect of cardio-metabolic traits on lung function. Multivariable MR suggested independence of these causal effects from other tested cardio-metabolic traits and diseases. Analysis of lung function specific SNPs revealed a potential causal effect of FEV1/FVC on blood pres
AU  - Wielscher,M
AU  - Amaral,AFS
AU  - van,der Plaat D
AU  - Wain,LV
AU  - Sebert,S
AU  - Mosen-Ansorena,D
AU  - Auvinen,J
AU  - Herzig,K-H
AU  - Dehghan,A
AU  - Jarvis,DL
AU  - Jarvelin,M-R
DO  - 10.1186/s13073-021-00914-x
PY  - 2021///
TI  - Genetic correlation and causal relationships between cardio-metabolic traits and lung function impairment
T2  - Genome Medicine
UR  - http://dx.doi.org/10.1186/s13073-021-00914-x
UR  - http://hdl.handle.net/10044/1/97061
VL  - 13
ER  -
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