Imperial College London
Portrait Picture

Dr Donna Kennedy

Faculty of Medicine, Department of Surgery & Cancer

Honorary Clinical Research Fellow
 
 
 
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Contact

 

+44 (0)20 3315 8424d.kennedy Website

 
 
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Location

 

Chelsea and Westminster HospitalChelsea and Westminster Campus

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Summary

 

Publications

Citation

BibTex format

@article{Kennedy:2020:10.1016/j.jpain.2019.09.010,
author = {Kennedy, DL and Kemp, H and Wu, C and Ridout, DA and Rice, ASC},
doi = {10.1016/j.jpain.2019.09.010},
journal = {Journal of Pain},
pages = {708--721},
title = {Determining real change in conditioned pain modulation: a repeated measures study in healthy volunteers},
url = {http://dx.doi.org/10.1016/j.jpain.2019.09.010},
volume = {21},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Conditioned pain modulation (CPM) is a potentially useful biomarker in pain populations; however, a statistically robust interpretation of change scores is required. Currently, reporting of CPM does not consider measurement error. Hence, the magnitude of change representing a “true” CPM effect is unknown. This study determined the standard error of measurement (SEM) and proportion of healthy participants showing a “true” CPM effect with a standard CPM paradigm. Fifty healthy volunteers participated in an intersession reliability study using pressure pain threshold (PPT) test stimulus and contact heat, cold water, and sham conditioning stimuli. Baseline PPTs were used to calculate SEM and >±2×SEM to determine CPM effect. SEM for PPT was .21 kg/cm2. An inhibitory CPM effect (>+2 SEM) was elicited in 59% of subjects in response to cold stimulus; in 44% to heat. Intrasession and intersession reliability of within-subject CPM response was poor (kappa coefficient <.36). Measurement error is important in determining CPM effect and change over time. Even when using reliable test stimuli, and incorporating measures to limit bias and error, CPM intersession reliability was fair and demonstrated a large degree of within-subject variation. Determining “true” change in CPM will underpin future interrogations of intraindividual differences in CPM.
AU  - Kennedy,DL
AU  - Kemp,H
AU  - Wu,C
AU  - Ridout,DA
AU  - Rice,ASC
DO  - 10.1016/j.jpain.2019.09.010
EP  - 721
PY  - 2020///
SN  - 1526-5900
SP  - 708
TI  - Determining real change in conditioned pain modulation: a repeated measures study in healthy volunteers
T2  - Journal of Pain
UR  - http://dx.doi.org/10.1016/j.jpain.2019.09.010
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000574819200017&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.sciencedirect.com/science/article/abs/pii/S1526590019308478?via%3Dihub
VL  - 21
ER  -
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