Summary
David Lane is Emeritus Professor of Molecular Haematology in the Centre for Haematology. He obtained a BA in Physics (1970) from the University of Essex and his PhD in 1974 from the University of London. He joined Imperial College (in the then Charing Cross and Westminster Medical School) in 1979. He was joint Editor-in-Chief of the Journal of Thrombosis & Haemostasis between 2007-2012. He was awarded a Distinguished Career Award from the International Society on Thrombosis and Haemostasis in 2011.
Highlighted publications:
South, K., Luken, B. M., Crawley, J. T., Phillips, R., Thomas, M., Collins, R. F., Deforche, L., Vanhoorelbeke, K., and Lane, D. A. (2014) Conformational activation of ADAMTS13, Proceedings of the National Academy of Sciences of the United States of America 111, 18578-18583.
Andersson, H. M., Siegerink, B., Luken, B. M., Crawley, J. T., Algra, A., Lane, D. A., and Rosendaal, F. R. (2012) High VWF, low ADAMTS13, and oral contraceptives increase the risk of ischemic stroke and myocardial infarction in young women, Blood 119, 1555-1560.
Xiang, Y., de Groot, R., Crawley, J. T., and Lane, D. A. (2011) Mechanism of von Willebrand factor scissile bond cleavage by a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13), Proceedings of the National Academy of Sciences of the United States of America 108, 11602-11607.
Crawley, J. T., de Groot, R., Xiang, Y., Luken, B. M., and Lane, D. A. (2011) Unraveling the scissile bond: how ADAMTS13 recognizes and cleaves von Willebrand factor, Blood 118, 3212-3221.
He is a member of the Haemostasis and Thrombosis Research Group, see http://www1.imperial.ac.uk/departmentofmedicine/divisions/experimentalmedicine/haematology/coag/
Publications
Journals
Ahnström J, Gierula M, Temenu J, et al., 2020, Partial rescue of naturally occurring active site factor X variants through decreased inhibition by tissue factor pathway inhibitor and antithrombin., Journal of Thrombosis and Haemostasis, Vol:18, ISSN:1538-7836, Pages:136-150
Gierula M, Salles‐Crawley II, Santamaria S, et al., 2019, The roles of factor Va and protein S in formation of the activated protein C/protein S/factor Va inactivation complex, Journal of Thrombosis and Haemostasis, ISSN:1538-7933
Santamaria S, Yamamoto Y, Teraz-Orosz A, et al., 2019, Exosites in hypervariable loops of ADAMTS dpacer domains control substrate recognition and proteolysis, Scientific Reports, Vol:9, ISSN:2045-2322
Crawley JTB, Zalli A, Monkman JH, et al., 2019, Defective fibrin deposition and thrombus stability in Bambi‐/‐ mice is mediated by elevated anticoagulant function, Journal of Thrombosis and Haemostasis, ISSN:1538-7933
Newnham M, South K, Bleda M, et al., 2019, The ADAMTS13-VWF axis is dysregulated in chronic thromboembolic pulmonary hypertension, European Respiratory Journal, Vol:53, ISSN:0903-1936