Imperial College London
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Emeritus Professor David Lane

Faculty of Medicine, Department of Immunology and Inflammation

Emeritus Professor of Haematology
 
 
 
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Contact

 

+44 (0)20 3313 2295d.lane

 
 
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Location

 

Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Maino:2015:10.1111/jth.13032,
author = {Maino, A and Siegerink, B and Lotta, LA and Crawley, JTB and Le, Cessie S and Leebeek, FWG and Lane, DA and Lowe, GDO and Peyvandi, F and Rosendaal, FR},
doi = {10.1111/jth.13032},
journal = {Journal of Thrombosis and Haemostasis},
pages = {1396--1404},
title = {Plasma ADAMTS-13 levels and the risk of myocardial infarction: an individual patient data meta-analysis},
url = {http://dx.doi.org/10.1111/jth.13032},
volume = {13},
year = {2015}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundLow ADAMTS-13 levels have been repeatedly associated with an increased risk of ischemic stroke, but results concerning the risk of myocardial infarction are inconclusive.ObjectivesTo perform an individual patient data meta-analysis from observational studies investigating the association between ADAMTS-13 levels and myocardial infarction.MethodsA one-step meta-analytic approach with random treatment effects was used to estimate pooled odds ratios (ORs) and corresponding 95% confidence intervals (CIs) adjusted for confounding. Analyses were based on dichotomous exposures, with the 5th and 1st percentiles of ADAMTS-13 antigen levels as cut-off values. Quartile analyses, with the highest quartile as a reference category, were used to assess a graded association between levels and risk (‘dose’ relationship). Additionally, we assessed the risk of the combined presence of low ADAMTS-13 and high von Willebrand factor (VWF) levels.ResultsFive studies were included, yielding individual data on 1501 cases and 2258 controls (mean age of 49 years). Low ADAMTS-13 levels were associated with myocardial infarction risk, with an OR of 1.89 (95% CI 1.15–3.12) for values below the 5th percentile versus above, and an OR of 4.21 (95% CI 1.73–10.21) for values below the 1st percentile versus above. Risk appeared to be restricted to these extreme levels, as there was no graded association between ADAMTS-13 levels and myocardial infarction risk over quartiles. Finally, there was only a minor synergistic effect for the combination of low ADAMTS-13 and high VWF levels.ConclusionsLow ADAMTS-13 levels are associated with an increased risk of myocardial infarction.
AU  - Maino,A
AU  - Siegerink,B
AU  - Lotta,LA
AU  - Crawley,JTB
AU  - Le,Cessie S
AU  - Leebeek,FWG
AU  - Lane,DA
AU  - Lowe,GDO
AU  - Peyvandi,F
AU  - Rosendaal,FR
DO  - 10.1111/jth.13032
EP  - 1404
PY  - 2015///
SN  - 1538-7933
SP  - 1396
TI  - Plasma ADAMTS-13 levels and the risk of myocardial infarction: an individual patient data meta-analysis
T2  - Journal of Thrombosis and Haemostasis
UR  - http://dx.doi.org/10.1111/jth.13032
UR  - http://hdl.handle.net/10044/1/26935
VL  - 13
ER  -
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