Imperial College London
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Emeritus Professor David Lane

Faculty of Medicine, Department of Immunology and Inflammation

Emeritus Professor of Haematology
 
 
 
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Contact

 

+44 (0)20 3313 2295d.lane

 
 
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Location

 

Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{South:2017:10.1111/jth.13898,
author = {South, K and Lane, DA},
doi = {10.1111/jth.13898},
journal = {Journal of Thrombosis and Haemostasis},
pages = {6--18},
title = {ADAMTS13 and von Willebrand factor: a Dynamic Duo},
url = {http://dx.doi.org/10.1111/jth.13898},
volume = {16},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - von Willebrand factor (VWF) is a key player in hemostasis, acting as a carrier for factor VIII and capturing platelets at sites of vascular damage. To capture platelets, it must undergo conformational changes, both within its A1 domain and at the macromolecular level through A2 domain unfolding. Its size and this function are regulated by the metalloproteinase ADAMTS-13. Recently, it has been shown that ADAMTS-13 undergoes a conformational change upon interaction with VWF, and that this enhances its activity towards its substrate. This review summarizes recent work on these conformational transitions, describing how they are controlled. It points to their importance in hemostasis, bleeding disorders, and the developing field of therapeutic application of ADAMTS-13 as an antithrombotic agent in obstructive microvascular thrombosis and in cardiovascular disease.
AU  - South,K
AU  - Lane,DA
DO  - 10.1111/jth.13898
EP  - 18
PY  - 2017///
SN  - 1538-7836
SP  - 6
TI  - ADAMTS13 and von Willebrand factor: a Dynamic Duo
T2  - Journal of Thrombosis and Haemostasis
UR  - http://dx.doi.org/10.1111/jth.13898
UR  - http://hdl.handle.net/10044/1/53061
VL  - 16
ER  -
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