Imperial College London

Mr Daniel Richard Leff

Faculty of MedicineDepartment of Surgery & Cancer

Reader in Breast Surgery
 
 
 
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Contact

 

+44 (0)20 3312 1947d.leff

 
 
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Location

 

Queen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Patel:2019:10.3389/fnins.2019.01213,
author = {Patel, R and Ashcroft, J and Patel, A and Ashrafian, H and Woods, A and Singh, H and Darzi, A and Leff, D},
doi = {10.3389/fnins.2019.01213},
journal = {Frontiers in Neuroscience},
title = {The impact of transcranial direct current stimulation on upper-limb motor performance in healthy adults: A systematic review and meta-analysis},
url = {http://dx.doi.org/10.3389/fnins.2019.01213},
volume = {13},
year = {2019}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Background: Transcranial direct current stimulation (tDCS) has previously been reported to improve facets of upper limb motor performance such as accuracy and strength. However, the magnitude of motor performance improvement has not been reviewed by contemporaneous systematic review or meta-analysis of sham vs. active tDCS.Objective: To systematically review and meta-analyse the existing evidence regarding the benefits of tDCS on upper limb motor performance in healthy adults.Methods: A systematic search was conducted to obtain relevant articles from three databases (MEDLINE, EMBASE, and PsycINFO) yielding 3,200 abstracts. Following independent assessment by two reviewers, a total of 86 articles were included for review, of which 37 were deemed suitable for meta-analysis.Results: Meta-analyses were performed for four outcome measures, namely: reaction time (RT), execution time (ET), time to task failure (TTF), and force. Further qualitative review was performed for accuracy and error. Statistically significant improvements in RT (effect size −0.01; 95% CI −0.02 to 0.001, p = 0.03) and ET (effect size −0.03; 95% CI −0.05 to −0.01, p = 0.017) were demonstrated compared to sham. In exercise tasks, increased force (effect size 0.10; 95% CI 0.08 to 0.13, p < 0.001) and a trend towards improved TTF was also observed.Conclusions: This meta-analysis provides evidence attesting to the impact of tDCS on upper limb motor performance in healthy adults. Improved performance is demonstrable in reaction time, task completion time, elbow flexion tasks and accuracy. Considerable heterogeneity exists amongst the literature, further confirming the need for a standardised approach to reporting tDCS studies.
AU - Patel,R
AU - Ashcroft,J
AU - Patel,A
AU - Ashrafian,H
AU - Woods,A
AU - Singh,H
AU - Darzi,A
AU - Leff,D
DO - 10.3389/fnins.2019.01213
PY - 2019///
SN - 1662-453X
TI - The impact of transcranial direct current stimulation on upper-limb motor performance in healthy adults: A systematic review and meta-analysis
T2 - Frontiers in Neuroscience
UR - http://dx.doi.org/10.3389/fnins.2019.01213
UR - http://hdl.handle.net/10044/1/74341
VL - 13
ER -