Publications
269 results found
Kulendran M, Leff DR, Kerr K, et al., 2013, Global cancer burden and sustainable health development, LANCET, Vol: 381, Pages: 427-429, ISSN: 0140-6736
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- Citations: 7
Patten DK, Leff DR, Wani Z, et al., 2013, Is the presence of small volume disease in the sentinel node an indication for axillary clearance?, BREAST, Vol: 22, Pages: 70-73, ISSN: 0960-9776
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- Citations: 2
Shetty K, Zander T, Leff DR, et al., 2013, Automated Cognitive Load Detection with Electroencephalography: Towards Brain-Computer Interfacing in Robotic Surgery, The 6th Hamlyn Symposium on Medical Robotics, Pages: 65-66
Clark J, Leff DR, Sodergren M, et al., 2012, Single-incision transumbilical levels 1 and 2 axillary lymph node dissection using a flexible endoscope in human cadaveric models, Surg Endosc
James DR, Leff DR, Orihuela-Espina F, et al., 2012, Enhanced frontoparietal network architectures following "gaze-contingent" versus "free-hand" motor learning., Neuroimage
Leff DR, Vincent C, Al-Mufti A, et al., 2012, A clinical "near miss" highlights risk management issues surrounding ultrasound-guided and wire-localised breast resections., Patient Safety in Surgery, Vol: 6, ISSN: 1754-9493
Background:The introduction of the National Health Service (NHS) Breast Screening Programme has led to aconsiderable increase in the detection of impalpable breast cancer. Patients with impalpable breast cancer typicallyundergo oncological resection facilitated either by the insertion of guide wires placed stereo-tactically or throughultra-sound guided skin markings to delineate the extent of a lesion. The need for radiological interventions on theday of surgery adds complexity and introduces the risk that a patient may accidentally transferred to the operatingroom directly without the image guidance procedure.Case report:A case is described of a patient who required a pre-operative ultrasound scan in order to localise animpalpable breast cancer but who was accidentally taken directly to the operating theatre (OR) and anaesthetisedwithout pre-operative intervention. The radiologist was called to the OR and an on-table ultrasound was performedwithout further consequence.Conclusion:It is evident that breast cancer patients undergoing image-guided resection are exposed to anadditional layer of clinical risks. These risks are not offset by the World Health Organisation surgical safety checklistin its present guise. Here, we review a number of simple and inexpensive changes to the system that may improvethe safety of the breast cancer patient undergoing surgery.
Mylonas GP, Kwok K-W, James DRC, et al., 2012, Gaze-Contingent Motor Channelling, haptic constraints and associated cognitive demand for robotic MIS, MEDICAL IMAGE ANALYSIS, Vol: 16, Pages: 612-631, ISSN: 1361-8415
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- Citations: 28
Yongue G, Leff DR, James DRC, et al., 2012, Expertise related disparity in prefrontal cortical excitation associated with intra-operative decision making, Annual Meeting of the Society-of-Academic-and-Research-Surgery, Publisher: WILEY-BLACKWELL, Pages: 39-39, ISSN: 0007-1323
Leff DR, Sait MR, Hanief M, et al., 2012, Inflammation of the residual appendix stump: a systematic review, COLORECTAL DISEASE, Vol: 14, Pages: 282-293, ISSN: 1462-8910
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- Citations: 17
Karimyan V, Orihuela-Espina F, Leff DR, et al., 2012, Spatial awareness in Natural Orifice Transluminal Endoscopic Surgery (NOTES) navigation, INTERNATIONAL JOURNAL OF SURGERY, Vol: 10, Pages: 80-86, ISSN: 1743-9191
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- Citations: 2
Patten DK, Wani Z, Leff DR, et al., 2011, A systematic review comparing surgical outcomes following implant and autologous breast reconstruction in post mastectomy breast cancer patients, International Surgical Congress of the Association-of-Surgeons-of-Great-Britain-and-Ireland, Publisher: WILEY-BLACKWELL, Pages: 198-198, ISSN: 0007-1323
James DRC, Orihuela-Espina F, Leff DR, et al., 2011, The ergonomics of natural orifice translumenal endoscopic surgery (NOTES) navigation in terms of performance, stress, and cognitive behavior, SURGERY, Vol: 149, Pages: 525-533, ISSN: 0039-6060
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- Citations: 23
Leff DR, Orihuela-Espina F, Elwell CE, et al., 2011, Assessment of the cerebral cortex during motor task behaviours in adults: A systematic review of functional near infrared spectroscopy (fNIRS) studies, NEUROIMAGE, Vol: 54, Pages: 2922-2936, ISSN: 1053-8119
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- Citations: 317
Leff DR, Vashisht R, Yongue G, et al., 2011, Endoscopic breast surgery: where are we now and what might the future hold for video-assisted breast surgery?, BREAST CANCER RESEARCH AND TREATMENT, Vol: 125, Pages: 607-625, ISSN: 0167-6806
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- Citations: 54
Hanief M, Aref F, Lamb BW, et al., 2011, A painful perineal lump: an unusual case of ectopic breast tissue, Annals of the Royal College of Surgeons of England, Vol: 93, Pages: e147-e148
Leff DR, Orihuela-Espina F, Athanasiou T, et al., 2010, "Circadian Cortical Compensation" <i>A Longitudinal Study of Brain Function During Technical and Cognitive Skills in Acutely Sleep</i>-<i>Deprived Surgical Residents</i>, ANNALS OF SURGERY, Vol: 252, Pages: 1082-1090, ISSN: 0003-4932
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- Citations: 23
Leff DR, Orihuela-Espina F, Athanasiou T, et al., 2010, Decoupling neurocognitive and technical performance in sleep deprived surgical residents through longitudinal analyses of cortical brain function: Advancing our understanding of compensation to acute fatigue, Annual Clinical Congress of American-College-of-Surgeons, Publisher: ELSEVIER SCIENCE INC, Pages: S118-S118, ISSN: 1072-7515
Orihuela-Espina F, Leff DR, James DRC, et al., 2010, Quality control and assurance in functional near infrared spectroscopy (fNIRS) experimentation, Physics in Medicine and Biology, Vol: 55, Pages: 3701-3724, ISSN: 1361-6560
Najefi A, Leff DR, Nicolaou M, et al., 2010, Monitoring of Free Flaps Using Near-Infrared Spectroscopy: A Systematic Review of the Initial Trials, PLASTIC AND RECONSTRUCTIVE SURGERY, Vol: 125, Pages: 182E-184E, ISSN: 0032-1052
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- Citations: 8
Leff DR, James DRC, Orihuela-Espina F, et al., 2010, The frontal cortex is activated during learning of endoscopic procedures (Ohuchida et al., Surgical Endoscopy, January 2009), SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES, Vol: 24, Pages: 968-969, ISSN: 0930-2794
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- Citations: 2
Unadkat SN, Leff DR, Teoh T-G, et al., 2010, Anorectal symptoms during pregnancy: how important is trimester?, INTERNATIONAL JOURNAL OF COLORECTAL DISEASE, Vol: 25, Pages: 375-379, ISSN: 0179-1958
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- Citations: 4
Saso S, Vecht JA, Rao C, et al., 2010, Statin therapy may influence the incidence of postoperative atrial fibrillation: what is the evidence?, Texas Heart Institute Journal, Vol: 36, Pages: 521-529, ISSN: 1526-6702
Atrial fibrillation is the most common postoperative arrhythmia in patients who undergo cardiac surgery. We sought to determine whether the administration of statins reduces the incidence of postoperative atrial fibrillation in cardiac surgery patients. We performed a meta-analysis on all studies published between 2004 and 2008 that reported comparisons between statin treatment or nontreatment in these patients. Our primary focus was the incidence of postoperative atrial fibrillation. Random-effects modeling and sensitivity analysis were used to evaluate the consistency of the calculated treatment effect. Ten qualifying studies generated a total of 4,459 patients. The incidence of postoperative atrial fibrillation was 22.6% (622/2,758) in the statin-treated group and 29.8% (507/1,701) in the untreated group. Using the random-effects model, we calculated an odds ratio (OR) of 0.60 (95% confidence interval [CI], 0.48-0.76). When we considered only the 4 randomized studies (919 patients) in order to reduce the effects of heterogeneity, this significant reduction in the incidence of postoperative atrial fibrillation in the statin group was maintained (OR, 0.55; 95% CI, 0.41-0.73) with no heterogeneity (chi2 of heterogeneity, 2.96; P = 0.4). In studies wherein only coronary artery bypass grafting was performed, statin treatment decreased postoperative atrial fibrillation (OR, 0.64; 95% CI, 0.43-0.95). We conclude that statin administration results in a reduction in the incidence of atrial fibrillation in patients who undergo cardiac surgery. Further research into the underlying mechanism can elucidate possible relationships between the dosage and type of statin used.
James DRC, Orihuela-Espina F, Leff DR, et al., 2010, Cognitive Burden Estimation for Visuomotor Learning with fNIRS, 13th International Conference on Medical Image Computing and Computer-Assisted Intervention (MICCAI), Publisher: SPRINGER-VERLAG BERLIN, Pages: 319-326, ISSN: 0302-9743
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- Citations: 17
Paggetti G, Menegaz G, Leff DR, et al., 2010, Exploring the link between depth perception, hand eye coordination and parietal lobe activation during robotic-assisted interventions, PERCEPTION, Vol: 39, Pages: 162-163, ISSN: 0301-0066
Paggetti G, Lin Y-C, Menegaz G, et al., 2010, DOES IT EXIST A LINK BETWEEN PERFORMANCE AND PARIETAL CORTEX ACTIVITY IN SURGICAL TASKS?, International Conference on Fuzzy Computation (ICFC 2010) and International Conference on Neural Computation (ICNC 2010), Publisher: SCITEPRESS, Pages: 381-384
Leff DR, Lovegrove RE, Darzi LA, et al., 2010, Data Collection, Database Development and Quality Control: Guidance for Clinical Research Studies, KEY TOPICS IN SURGICAL RESEARCH AND METHODOLOGY, Editors: Athanasiou, Debas, Darzi, Publisher: SPRINGER-VERLAG BERLIN, Pages: 305-320, ISBN: 978-3-540-71914-4
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- Citations: 1
Saso S, Vecht JA, Rao C, et al., 2009, Statin Therapy May Influence the Incidence of Postoperative Atrial Fibrillation What Is the Evidence?, TEXAS HEART INSTITUTE JOURNAL, Vol: 36, Pages: 521-529, ISSN: 0730-2347
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- Citations: 10
Leff DR, Heath D, 2009, Surgery for obesity in adulthood., BMJ, Vol: 339
Leff DR, Hassell J, Sufi P, et al., 2009, Emergency and elective laparoscopic repair of spigelian hernias: two case reports and a review of the literature, Surgical Laparoscopy, Endoscopy & Percutaneous Techniques, Vol: 19, Pages: e152-e155, ISSN: 1530-4515
Diagnosing spigelian hernias through physical examinationcan be particularly challenging. Increasingly, laparoscopy isbeing used to both confirm the diagnosis and carry out therapeuticrepair. Here, we describe 2 cases of successful laparoscopic repairof spigelian hernias using an Endocatch assisted sutured technique.A review of the literature describing the role of laparoscopy in themanagement of spigelian hernia is also provided.
Patten DK, Layfield D, Arya S, et al., 2009, Single Best Answers in Surgery (SBA), Publisher: Hodder and Arnold, ISBN: 978-0340972359
Single Best Answers in Surgery offers a new approach to revising for surgical finals; by not only indicating the correct answer to each question, but explaining the full rationale used for finding the answer in each case. This means the book is invaluable not only for self-testing before an exam, but will have long-term value throughout a student's surgical studies, through to finals exams and beyond. The questions are arranged into topic areas, followed by a practice exam for true self-assessment.
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