Imperial College London
Alternate

PROFESSOR DAVID HANSELL

Faculty of Medicine, National Heart & Lung Institute

Emeritus Professor of Thoracic Imaging
 
 
 
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Contact

 

d.m.hansell Website

 
 
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Location

 

RadiologySouth BlockRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Egashira:2017:10.1148/radiol.2017152419,
author = {Egashira, R and Jacob, J and Kokosi, MA and Brun, A-L and Rice, A and Nicholson, AG and Wells, AU and Hansell, DM},
doi = {10.1148/radiol.2017152419},
journal = {Radiology},
pages = {255--263},
title = {Diffuse Pulmonary Ossification in Fibrosing Interstitial Lung Diseases: Prevalence and Associations},
url = {http://dx.doi.org/10.1148/radiol.2017152419},
volume = {284},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - PurposeTo investigate the prevalence of diffuse pulmonary ossification (DPO) in patients with fibrosing interstitial lung disease (ILD) and determine whether there are differences among the types of ILDs.Materials and MethodsInstitutional review board approval was given and patient consent was not required for this study. The study population comprised 892 consecutive patients with fibrosing ILD, including 456 patients with idiopathic pulmonary fibrosis (IPF) (men, 366; women, 90; median age, 72 years [range, 38–93 years]), 244 with nonspecific interstitial pneumonia (men, 79; women, 165; median age, 60.5 years [range, 23–86 years]), and 192 with chronic hypersensitivity pneumonitis (men, 76; women, 116; median age, 66 years [range, 35–88 years]). Pulmonary ossifications were recorded when nodules (<4 mm diameter) were identified on bone window images (width, 2500 HU; level, 500 HU). DPO was defined as 10 or more bilateral nodular ossifications (definition 1) or as one or more lobes with five or more bilateral nodular ossifications (definition 2). Relationships among pulmonary ossification and parenchymal patterns, clinical parameters, and multidisciplinary team diagnoses were examined. The prevalence of DPO was compared with the χ2 statistic or Fisher exact test, and multivariate analysis was performed with logistic regression.ResultsIn the whole population, the prevalence of DPO was 166 (18.6%) and 106 (11.9%) of 892 patients according to definitions 1 and 2, respectively. The prevalence of DPO (definition 1) was significantly higher in patients with IPF (28.5%) than in those without IPF (8.3%, P < .001). Nine of 192 (4.7%) had chronic hypersensitivity pneumonitis (P < .001), and 27 of 244 (11.1%) had nonspecific interstitial pneumonia (P < .001). At multivariate analysis, DPO according to definition 1 was an independent predictor of IPF diagnosis (P < .001) and male sex (P = .003). Coarseness of fibrosing ILD (P = .011) and IP
AU  - Egashira,R
AU  - Jacob,J
AU  - Kokosi,MA
AU  - Brun,A-L
AU  - Rice,A
AU  - Nicholson,AG
AU  - Wells,AU
AU  - Hansell,DM
DO  - 10.1148/radiol.2017152419
EP  - 263
PY  - 2017///
SN  - 0033-8419
SP  - 255
TI  - Diffuse Pulmonary Ossification in Fibrosing Interstitial Lung Diseases: Prevalence and Associations
T2  - Radiology
UR  - http://dx.doi.org/10.1148/radiol.2017152419
VL  - 284
ER  -
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