Publications
398 results found
Lan F, Lin G, Cao G, et al., 2020, Altered Intrinsic Brain Activity and Functional Connectivity Before and After Knee Arthroplasty in the Elderly: A Resting-State fMRI Study, FRONTIERS IN NEUROLOGY, Vol: 11, ISSN: 1664-2295
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- Citations: 8
Ma DAQING, 2020, Propofol induced MiR-20b expression initiates endogenous cellular signal changes mitigating hypoxia/re-oxygenation-induced endothelial autophagy in vitro, Cell Death and Disease, ISSN: 2041-4889
Ishikawa M, Sakamoto A, Ma D, 2020, Recurrence of breast cancer after anaesthesia, LANCET, Vol: 396, Pages: 375-376, ISSN: 0140-6736
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- Citations: 2
Yang S-R, Hua K-F, Chu LJ, et al., 2020, Xenon blunts NF-κB/NLRP3 inflammasome activation and improves acute onset of accelerated and severe lupus nephritis in mice, KIDNEY INTERNATIONAL, Vol: 98, Pages: 378-390, ISSN: 0085-2538
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- Citations: 18
Jin Z, Hana Z, Alam A, et al., 2020, Review 1: Lung transplant-from donor selection to graft preparation, JOURNAL OF ANESTHESIA, Vol: 34, Pages: 561-574, ISSN: 0913-8668
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- Citations: 2
Hu C, Iwasaki M, Liu Z, et al., 2020, Propofol Attenuates Lung but not Brain Cancer Cell Malignancy through Metabolism and Cell Signaling Modulation In Vitro
<jats:title>Abstract</jats:title> <jats:p>Background: Intravenous anesthesia with propofol was reported to improve cancer surgical outcomes when compared with inhalational anesthesia. However, the underlying molecular mechanisms largely remain unknown. The current study aims to investigate whether propofol affects cancer cell biology including tumor metastasis-related gene expression, cellular signaling and metabolic changes in lung and brain cancer cells.Methods: Lung cancer (A549) or neuroglioma (H4) cells were treated with propofol at a clinically relevant concentration (4 μg/mL) for 2 hours, followed by 24 hours recovery. Tumor metastasis-related gene expressions were assessed using a PCR array and validated with qRT-PCR. Glucose transporter 1 (GLUT1), brain protein 44-like (BRP44L), pigment epithelium-derived factor (PEDF), Akt, phospho-Akt (p-Akt), extracellular-signal-regulated kinase 1/2 (Erk1/2), phospho-Erk1/2 (p-Erk1/2), and hypoxia-inducible factor 1 alpha (HIF-1α) expressions were determined using immunofluorescent staining and/or western blotting. The metabolites in cell extract and media following propofol treatment were characterized using proton nuclear magnetic resonance ( 1 H NMR) spectroscopy. The malignant hallmarks including cell viability, proliferation, migration, and invasion were evaluated using cell counting kit-8 (CCK-8) assay, Ki-67 staining, wound healing and transwell assay, respectively.Results: Propofol reduced cell viability and inhibited cell proliferation, migration and invasion of lung cancer cells, but not neuroglioma cells. In lung cancer cells, gene expressions of VEGFA, CTBP1, CST7, CTSK, CXCL12, and CXCR4 were downregulated, while NR4A3, RB1, NME1, MTSS1, NME4, SYK, APC, and FAT1 were upregulated following the propofol treatment. Furthermore, propofol downregulated GLUT1, BRP44L, p-Akt, p-Erk, and HIF-1α expressions in lung cancer cells and upregulated PEDF expression. Propofol increas
Chen R, Zeng Z, Zhang Y-Y, et al., 2020, Ischemic postconditioning attenuates acute kidney injury following intestinal ischemia-reperfusion through Nrf2-regulated autophagy, anti-oxidation, and anti-inflammation in mice, FASEB JOURNAL, Vol: 34, Pages: 8887-8901, ISSN: 0892-6638
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- Citations: 14
Wei W, Fan Y, Liu W, et al., 2020, Combined non-intubated anaesthesia and paravertebral nerve block in comparison with intubated anaesthesia in children undergoing video-assisted thoracic surgery, ACTA ANAESTHESIOLOGICA SCANDINAVICA, Vol: 64, Pages: 810-818, ISSN: 0001-5172
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- Citations: 5
Rampes S, Ma K, Divecha YA, et al., 2020, Postoperative sleep disorders and their potential impacts on surgical outcomes, JOURNAL OF BIOMEDICAL RESEARCH, Vol: 34, Pages: 271-280, ISSN: 1674-8301
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- Citations: 28
Huang W-W, Zhu W-Z, Mu D-L, et al., 2020, Intraoperative hypotension is associated with shortened overall survival after lung cancer surgery, BMC ANESTHESIOLOGY, Vol: 20, ISSN: 1471-2253
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- Citations: 4
Ni C, Masters J, Zhu L, et al., 2020, Study design of the DAS-OLT trial: a randomized controlled trial to evaluate the impact of dexmedetomidine on early allograft dysfunction following liver transplantation, TRIALS, Vol: 21
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- Citations: 3
Saito J, Ma D, 2020, Can dexmedetomidine protect against surgical stress response?, CLINICAL AND TRANSLATIONAL MEDICINE, Vol: 10, ISSN: 2001-1326
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- Citations: 1
Zhang W, Sheng B, Chen S, et al., 2020, Sevoflurane Enhances Proliferation, Metastatic Potential of Cervical Cancer Cells <i>via</i> the Histone Deacetylase 6 Modulation <i>In Vitro</i>, ANESTHESIOLOGY, Vol: 132, Pages: 1469-1481, ISSN: 0003-3022
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- Citations: 18
Hu C, Liu Z, Zhao H, et al., 2020, A biochemical comparison of the lung, colonic, brain, renal, and ovarian cancer cell lines using 1H-NMR spectroscopy, Bioscience Reports, Vol: 40, ISSN: 0144-8463
Cancer cell lines are very often used for cancer research. However, continuous genetic instability-induced heterogeneity of cell lines can hinder the reproducibility of cancer research. Molecular profiling approaches including transcriptomics, chromatin modification profiling and proteomics are used to evaluate the phenotypic characteristics of cell lines. However, these do not reflect the metabolic function at the molecular level. Metabolic phenotyping is a powerful tool to profile the biochemical composition of cell lines. In this study, 1H-NMR spectroscopy-based metabolic phenotyping was used to detect metabolic differences among 5 cancer cell lines, namely, lung (A549), colonic (Caco2), brain (H4), renal (RCC), and ovarian (SKOV3) cancer cells. The concentrations of choline, creatine, lactate, alanine, fumarate and succinate varied remarkably among different cell types.The significantly higher intracellular concentrations of glutathione, myo-inositol, and phosphocholine were found in the SKOV3 cell line relative to other cell lines. Glutamate is higher in both SKOV3 and RCC cells compared to other cell lines. For cell culture media analysis, isopropanol was found to be the highest in RCC media, followed by A549 and SKOV3 media, while acetone was the highest in A549, followed by RCC and SKOV3. These results demonstrated that 1H-NMR-based metabolic phenotyping approach allows us to characterize specific metabolic signatures of cancer cell lines and provides phenotypical information of cellular metabolism.
Meng C, Yao X-Q, Chang R-J, et al., 2020, Exogenous GM1 Ganglioside Attenuates Ketamine-Induced Neurocognitive Impairment in the Developing Rat Brain, ANESTHESIA AND ANALGESIA, Vol: 130, Pages: 505-517, ISSN: 0003-2999
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- Citations: 15
Guo Y, Li Y, Zhang Y, et al., 2020, Post-operative delirium associated with metabolic alterations following hemi-arthroplasty in older patients, Age and Ageing, Vol: 49, Pages: 88-95, ISSN: 0002-0729
Backgroundpost-operative delirium (POD) is a common complication in older patients, though a possible link between metabolic changes and POD development has yet to be investigated.Methodsolder patients with hip fracture who underwent hemi-arthroplasty were recruited, and delirious states were assessed for 3 days after surgery using the confusion assessment method-Chinese revision. Simultaneously, fasting blood samples were collected on the morning of surgery and on the first post-operative day. Ultimately, 244 older patients who met the inclusion and exclusion criteria were assessed. Blood samples from 60 patients with POD and 60 matched controls were analysed using metabolomics platforms.Resultssixty patients (24.6%) developed POD. Principal component analysis scores plot and cross-validated scores plots from orthogonal partial least squares-discriminant analysis were implemented to visualise the differences in metabolites between the two groups before and after surgery (P < 0.05). Our data indicate that levels of ω3 and ω6 fatty acids were lower in the POD group than in the NPOD (non-POD) group both before and after surgery; tricarboxylic cycle intermediate levels were lower in the POD group than in the NPOD group, but glycolysis products were higher in the POD group than in the NPOD group after surgery. Furthermore, the branched-chain amino acid (BCAA)/aromatic amino acid ratio was lower in the POD group than in the NPOD group after surgery.Conclusionsmetabolic abnormalities, including deficiencies in ω3 and ω6 fatty acids, perturbations in tricarboxylic cycle and oxidative stress and metabolic imbalances in BCAA and AAA might contribute to POD development.
Li C-J, Wang B-J, Mu D-L, et al., 2020, Randomized clinical trial of intraoperative dexmedetomidine to prevent delirium in the elderly undergoing major non-cardiac surgery, BRITISH JOURNAL OF SURGERY, Vol: 107, Pages: E123-E132, ISSN: 0007-1323
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- Citations: 46
Chen H-P, Wang X-Y, Pan X-Y, et al., 2020, Circulating Neutrophil-Derived Microparticles Associated with the Prognosis of Patients with Sepsis, JOURNAL OF INFLAMMATION RESEARCH, Vol: 13, Pages: 1113-1124
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- Citations: 16
Dobrovolsky AP, Gedzun VR, Bogin VI, et al., 2019, Beneficial effects of xenon inhalation on behavioral changes in a valproic acid-induced model of autism in rats, JOURNAL OF TRANSLATIONAL MEDICINE, Vol: 17
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- Citations: 4
Wang K, Wu M, Xu J, et al., 2019, Effects of dexmedetomidine on perioperative stress, inflammation, and immune function: systematic review and meta-analysis, BRITISH JOURNAL OF ANAESTHESIA, Vol: 123, Pages: 777-794, ISSN: 0007-0912
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- Citations: 130
Ji C, Ni Q, Chen W, et al., 2019, General anesthetic neurotoxicity in the young: Mechanism and prevention, NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, Vol: 107, Pages: 883-896, ISSN: 0149-7634
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- Citations: 9
Shi J, Yu J, Zhang Y, et al., 2019, PI3K/Akt pathway-mediated HO-1 induction regulates mitochondrial quality control and attenuates endotoxin-induced acute lung injury, LABORATORY INVESTIGATION, Vol: 99, Pages: 1795-1809, ISSN: 0023-6837
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- Citations: 65
Hu C, Liu Z, Iwasaki M, et al., 2019, Propofol inhibits cancer malignancy by disturbing glucose metabolism through hypoxia-inducible factor-1 alpha and pigment epithelium-derived factor modulation, BJA Research Forum, Publisher: ELSEVIER SCI LTD, Pages: E499-E500, ISSN: 0007-0912
Saito J, Masters J, Hirota K, et al., 2019, Anesthesia and brain tumor surgery: technical considerations based on current research evidence, CURRENT OPINION IN ANESTHESIOLOGY, Vol: 32, Pages: 553-562, ISSN: 0952-7907
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- Citations: 9
Zhao H, Chen Q, Huang H, et al., 2019, Osteopontin mediates necroptosis in lung injury after transplantation of ischaemic renal allografts in rats, BRITISH JOURNAL OF ANAESTHESIA, Vol: 123, Pages: 519-530, ISSN: 0007-0912
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- Citations: 9
Li X, Cui J, Wu L, et al., 2019, Bv8 contributes to neutrophil infiltration and triggers the angiogenesis of colon cancer <i>via</i> extracellular signal-regulated kinase-vascular endothelial growth factor signalling pathway, BJA Research Forum, Publisher: ELSEVIER SCI LTD, Pages: E500-E500, ISSN: 0007-0912
Chang E, Wu L, Masters J, et al., 2019, Iatrogenic subglottic tracheal stenosis after tracheostomy and endotracheal intubation: A cohort observational study of more severity in keloid phenotype, ACTA ANAESTHESIOLOGICA SCANDINAVICA, Vol: 63, Pages: 905-912, ISSN: 0001-5172
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- Citations: 14
Wall T, Sherwin A, Ma D, et al., 2019, Influence or perioperative anaestnetic and analgesic interventions oncological outcomes: a narrative review, BRITISH JOURNAL OF ANAESTHESIA, Vol: 123, Pages: 135-150, ISSN: 0007-0912
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- Citations: 128
Perry NJS, Ma D, 2019, Cancer and Other Outcomes After Surgery With Fluoridated Anesthesia—Reply, JAMA Surgery, ISSN: 2168-6254
Forget P, Aguirre JA, Bencic I, et al., 2019, How Anesthetic, Analgesic and Other Non-Surgical Techniques During Cancer Surgery Might Affect Postoperative Oncologic Outcomes: A Summary of Current State of Evidence, CANCERS, Vol: 11
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- Citations: 38
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