Publications
400 results found
Ma D, Zhao H, 2018, VEGF mitigates histone-induced pyroptosis in the remote liver injury associated with renal allograft ischemia-reperfusion injury in rats., American Journal of Transplantation, ISSN: 1600-6135
Zac H, Suha A, Azeem A, et al., 2018, Ketamine: Old Drug but New Use for Neuropathic Pain, Translational Perioperative and Pain Medicine, Vol: 5
Wu Y, Wang X, Wang N, et al., 2018, Regularity changes of the retinal nerve fiber layer and macular ganglion cell complex in patients with the amnestic mild cognitive impairment, International Journal of Neuroscience, Vol: 128, Pages: 849-853, ISSN: 0020-7454
Purpose/aim: We investigated the regularity changes of the retinal nerve fiber layer (RNFL) and macular ganglion cell complex (mGCC) of the amnestic mild cognitive impairment (aMCI) patients in this prospective cohort study.Materials and methods: Twenty-four aMCI patients and 30 health controls, who are more than 60 years old, were recruited into the study. The RNFL and the mGCC average thickness were measured with Fourier-domain optical coherence tomography (FD-OCT).Results: Compared with that in the controls, the intraocular pressure (IOP) was significantly lower in the aMCI patients. A significant decrease in RNFL thickness in superior temporal, temporal upper (TU), and temporal upper and lower (TL) (TU+TL) quadrants was found in the aMCI patients than in the controls. The average thickness of the mGCC was also significantly thinner in the aMCI patients than in the controls.Conclusions: Retinal degeneration in the aMCI patients detected by OCT together with lower IOP may indicate disease pathological progression.
Zhao H, Alam A, Pac Soo A, et al., 2018, Ischemia-reperfusion injury reduces long term renal graft survival: mechanism and beyond, EBioMedicine, Vol: 28, Pages: 31-42, ISSN: 2352-3964
Ischemia-reperfusion injury (IRI) during renal transplantation often initiates non-specific inflammatory responses that can result in the loss of kidney graft viability. However, the long-term consequence of IRI on renal grafts survival is uncertain. Here we review clinical evidence and laboratory studies, and elucidate the association between early IRI and later graft loss. Our critical analysis of previous publications indicates that early IRI does contribute to later graft loss through reduction of renal functional mass, graft vascular injury, and chronic hypoxia, as well as subsequent fibrosis. IRI is also known to induce kidney allograft dysfunction and acute rejection, reducing graft survival. Therefore, attempts have been made to substitute traditional preserving solutions with novel agents, yielding promising results.
Singh M, Nabavi E, Zhou Y, et al., 2018, Fluorescence image-guided photothermal therapy: Diagnosis and treatment of upper gastrointestinal cancer and beyond (prize winner), Global Surgery
Ciechanowicz S, Zhao H, Chen Q, et al., 2018, Differential effects of sevoflurane on the metastatic potential and chemosensitivity of non-small-cell lung adenocarcinoma and renal cell carcinoma <i>in vitro</i>, BRITISH JOURNAL OF ANAESTHESIA, Vol: 120, Pages: 368-375, ISSN: 0007-0912
- Author Web Link
- Cite
- Citations: 48
Zhang Y, Li H-J, Wang D-X, et al., 2017, Impact of inhalational versus intravenous anaesthesia on early delirium and long-term survival in elderly patients after cancer surgery: study protocol of a multicentre, open-label, and randomised controlled trial., BMJ Open, Vol: 7, ISSN: 2044-6055
Introduction Elderly patients who have solid organ cancer often receive surgery. Some of them may develop delirium after surgery and delirium development is associated with worse outcomes. Furthermore, despite all of the advances in medical care, the long-term survival in cancer patients is far from optimal. Evidences suggest that choice of anaesthetics during surgery, that is, either inhalational or intravenous anaesthetics, may influence outcomes. However, the impact of general anaesthesia type on the occurrence of postoperative delirium is inconclusive. Although retrospective studies suggest that propofol-based intravenous anaesthesia was associated with longer survival after cancer surgery when compared with inhalational anaesthesia, prospective studies as such are still lacking. The purposes of this randomised controlled trial are to test the hypotheses that when compared with sevoflurane-based inhalational anaesthesia, propofol-based intravenous anaesthesia may reduce the incidence of early delirium and prolong long-term survival in elderly patients after major cancer surgery.Methods and analysis This is a multicentre, open-label, randomised controlled trial with two parallel arms. 1200 elderly patients (≥65 years but <90 years) who are scheduled to undergo major cancer surgery (with predicted duration ≥2 hours) are randomised to receive either sevoflurane-based inhalational anaesthesia or propofol-based intravenous anaesthesia. Other anaesthetics and supplemental drugs including sedatives, opioids and muscle relaxants are administered in both arms according to routine practice. The primary early outcome is the incidence of 7-day delirium after surgery and the primary long-term outcome is the duration of 3-year survival after surgery.Ethics and dissemination The study protocol has been approved by the Clinical Research Ethics Committees of Peking University First Hospital (2015[869]) and all participating centres. The results of early and long-
Zhao H, Rossaint R, Coburn M, et al., 2017, The renoprotective properties of xenon and argon in kidney transplantation, EUROPEAN JOURNAL OF ANAESTHESIOLOGY, Vol: 34, Pages: 637-640, ISSN: 0265-0215
Li X, Yang J, Nie X-L, et al., 2017, Effect of epidural and combined spinal epidural labour analgesia on the occurrence of postpartum depression: amulticentre cohort study, 24th Annual Meeting of the Chinese-Society-of-Anesthesiology, Publisher: OXFORD UNIV PRESS, Pages: E48-E49, ISSN: 0007-0912
- Author Web Link
- Cite
- Citations: 1
Liu D, Li Z, Zhang X, et al., 2017, Assessment of intracranial pressure with ultrasonographic retrobulbar optic nerve sheath diameter measurement, BMC Neurology, Vol: 17, ISSN: 1471-2377
BackgroundUltrasonograpic retrobulbar optic nerve sheath diameter (ONSD) measurement is considered to be an alternative noninvasive method to estimate intracranial pressure,but the further validation is urgently needed. The aim of the current study was to investigate the association of the ultrasonographic ONSD and intracranial pressure (ICP) in patients.MethodsOne hundred and ten patients whose intracranial pressure measured via lumbar puncture were enrolled in the study. Their retrobulbar ONSD with B-scan ultrasound was determined just before lumber puncture. The correlation between the ICP and the body mass index (BMI), ONSD or age was established respectively with the Pearson correlation coefficient analysis. The discriminant analysis was used to obtain a discriminant formula for predicting ICP with the ONSD、BMI、gender and age. Another 20 patients were recruited for further validation the efficiency of this discriminant equation.ResultsThe mean ICP was 215.3 ± 81.2 mmH2O. ONSD was 5.70 ± 0.80 mm in the right eye and 5.80 ± 0.77 mm in the left eye. A significant correlation was found between ICP and BMI (r = 0.554, p < 0.001), the mean ONSD (r = 0.61, P < 0.001), but not with age (r = −0.131, p = 0.174) and gender (r = 0.03, p = 0.753). Using receiver operating characteristic (ROC) curve analysis, the critical value for the risk mean-ONSD was 5.6 mm from the ROC curve, with the sensitivity of 86.2% and specificity of 73.1%. With 200 mmH2O as the cutoff point for a high or low ICP, stepwise discriminant was applied, the sensitivity and specificity of ONSD predicting ICP was 84.5%-85.7% and 86.5%-92.3%.ConclusionsOphthalmic ultrasound measurement of ONSD may be a good surrogate of invasive ICP measurement. This non-invasive method may be an alternative approach to predict the ICP value of patients whose ICP measurement via lumbar puncture are in high risk. The discriminant formula, which incorporated the factor of BMI, had similar s
Sanders RD, Andropoulos D, Ma D, et al., 2017, Theseus, the Labyrinth, and the Minotaur of anaesthetic-induced developmental neurotoxicity, BRITISH JOURNAL OF ANAESTHESIA, Vol: 119, Pages: 453-455, ISSN: 0007-0912
Zhao H, Ma D, Alam A, 2017, EXPOSURE TO ARGON AT EX VIVO STAGE PROTECTS RAT DCD RENAL ALLOGRAFT AGAINST ISCHEMIC-HYPOTHERMIC INJURY, Publisher: WILEY, Pages: 66-66, ISSN: 0934-0874
Wang DX, Ma D, 2017, In reply, Anesthesiology, Vol: 127, Pages: 398-399, ISSN: 0003-3022
Chen Q, Zhao H, Gu J, et al., 2017, Dexmedetomidine modulates lung alveolar macrophage polarization in vitro, British Journal of Anaesthesia (BJA) Research Forum, Publisher: OXFORD UNIV PRESS, Pages: E25-E26, ISSN: 0007-0912
Suen KC, Zhao H, Ma D, 2017, Histone release mediated necroptosis in remote lung injury following renal allograft ischemia-reperfusion injury in rats, British Journal of Anaesthesia (BJA) Research Forum, Publisher: OXFORD UNIV PRESS, Pages: E25-E25, ISSN: 0007-0912
Jaffer T, Ma D, 2017, The effects of sevoflurane and propofol on ovarian cancer in vitro, British Journal of Anaesthesia (BJA) Research Forum, Publisher: OXFORD UNIV PRESS, Pages: E24-E24, ISSN: 0007-0912
Zhao H, Chen Q, Suen K, et al., 2017, Osteopontin mediates necroptosis in remote lung injury after receiving ischemic renal allografts in rats, British Journal of Anaesthesia (BJA) Research Forum, Publisher: OXFORD UNIV PRESS, Pages: E29-E29, ISSN: 0007-0912
Zhang W, Zhu X, Lian Q, et al., 2017, Sevoflurane enhances proliferation, migration and invasion of cervical cancer cells in vitro, British Journal of Anaesthesia (BJA) Research Forum, Publisher: OXFORD UNIV PRESS, Pages: E23-E24, ISSN: 0007-0912
Zhao H, Alam A, San C-Y, et al., 2017, Molecular mechanisms of brain-derived neurotrophic factor in neuroprotection: Recent developments, BRAIN RESEARCH, Vol: 1665, Pages: 1-21, ISSN: 0006-8993
- Author Web Link
- Cite
- Citations: 81
Dobrovolsky A, Ichim TE, Ma D, et al., 2017, Xenon in the treatment of panic disorder: an open label study, JOURNAL OF TRANSLATIONAL MEDICINE, Vol: 15, ISSN: 1479-5876
- Author Web Link
- Cite
- Citations: 11
Silk E, Zhao H, Weng H, et al., 2017, The role of extracellular histone in organ injury, Cell Death & Disease, Vol: 8, ISSN: 2041-4889
Histones are intra-nuclear cationic proteins that are present in all eukaryotic cells and are highly conserved acrosss pecies. Within the nucleus, they provide structural stability to chromatin and regulate gene expression. Histone may be released into the extracellular space in three forms: freely, as a DNA-bound nucleosome or as part of neutrophilextracellular traps, and all three can be deteted in serum after significant cellular death such as sepsis, trauma, ischaemia/reperfusion (I/R) injury and autoimmune disease. Once in the extracellular space, histones actas Damage-Associated Molecular Pattern (DAMP) proteins,activating theimmune system and causing further cytotoxicity. They interact with Toll-Like Receptors (TLRs), complement and the phospholipids of cell membranes inducing endothelial and epithelial cytotoxicity, TLR2/TLR4/TLR9 activation and pro-inflammatory cytokine/chemokine release via MyD88, NFκB and NLRP3 inflammasome dependent pathways. Drugs that block the release of histone, neutralise circulating histone or block histone signal transduction provide significant protection from mortality in animal models of acute organinjury but warrant further research to in form future clinical applications.
Ma D, Zhao H, 2017, Differential effects of sevoflurane on the metastatic potential and chemosensitivity of non-small-cell lung adenocarcinoma and renal cell carcinoma in vitro., Br J Anaesth
Xu Y, Li Y, Huang X, et al., 2017, Single bolus low-dose of ketamine does not prevent postpartum depression: a randomized, double-blind, placebo-controlled, prospective clinical trial, ARCHIVES OF GYNECOLOGY AND OBSTETRICS, Vol: 295, Pages: 1167-1174, ISSN: 0932-0067
- Author Web Link
- Cite
- Citations: 38
Alam A, Suen KC, Ma D, 2017, Acute-on-chronic liver failure: recent update, JOURNAL OF BIOMEDICAL RESEARCH, Vol: 31, Pages: 283-300, ISSN: 1674-8301
Zhao H, Alam A, Chen Q, et al., 2017, The role of microglia in the pathobiology of neuropathic pain development: what do we know?, BRITISH JOURNAL OF ANAESTHESIA, Vol: 118, Pages: 504-516, ISSN: 0007-0912
Su X, Wang D-X, Ma D, 2017, Preventing delirium: beyond dexmedetomidine Reply, LANCET, Vol: 389, Pages: 1009-1010, ISSN: 0140-6736
Li X, Yang J, Nie X-L, et al., 2017, Impact of dexmedetomidine on the incidence of delirium in elderly patients after cardiac surgery: A randomized controlled trial, PLOS ONE, Vol: 12, ISSN: 1932-6203
- Author Web Link
- Cite
- Citations: 82
Zhao H, Eguchi S, Alam A, et al., 2017, The role of nuclear factor-erythroid 2 related factor 2 (Nrf-2) in the protection against lung injury, AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, Vol: 312, Pages: L155-L162, ISSN: 1040-0605
Goh EL, Chidambaram S, Ma D, 2017, Complex regional pain syndrome: a recent update, BURNS & TRAUMA, Vol: 5, ISSN: 2321-3868
- Author Web Link
- Cite
- Citations: 86
Alam A, Suen KC, Hana Z, et al., 2017, Neuroprotection and neurotoxicity in the developing brain: an update on the effects of dexmedetomidine and xenon, NEUROTOXICOLOGY AND TERATOLOGY, Vol: 60, Pages: 102-116, ISSN: 0892-0362
This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.