Summary
Dr David MacIntyre is a Reader in Reproductive Systems Medicine.
Description of research interests:
Our research is focused on understanding the role of inflammation and infection of the reproductive tract during pregnancy. We are particularly interested in understanding how vaginal microbiota and their interactions with the maternal host can influence poor pregnancy outcomes such as miscarriage, preterm premature rupture of membranes (PPROM) and preterm birth. This is achieved through a combination of classical biochemistry methods as well as “systems” modelling approaches that involve integration and analysis of genomic, transcriptomic, microbiomic and metabolic profiling data. It is hoped that will lead to improved diagnostic and predictive tools that will assist in patient stratification and ultimately, improved pregnancy outcomes.
Selected Publications
Journal Articles
Brown RG, Al-Memar M, Marchesi JR, et al., 2019, Establishment of vaginal microbiota composition in early pregnancy and its association with subsequent preterm prelabour rupture of the fetal membranes, Translational Research, Vol:207, ISSN:1931-5244, Pages:30-43
Pruski P, Lewis H, Lee Y, et al., 2018, Assessment of microbiota:host interactions at the vaginal mucosa interface, Methods, Vol:149, ISSN:1046-2023, Pages:74-84
MacIntyre DA, Brown R, Marchesi J, et al., 2018, Vaginal dysbiosis increases risk of preterm fetal membrane rupture, neonatal sepsis and is exacerbated by erythromycin, BMC Medicine, Vol:16, ISSN:1741-7015
Kindinger LM, MacIntyre DA, Lee YS, et al., 2016, Relationship between vaginal microbial dysbiosis, inflammation, and pregnancy outcomes in cervical cerclage., Sci Transl Med, Vol:8