Summary
Dr David MacIntyre is a Reader in Reproductive Systems Medicine.
Description of research interests:
Our research is focused on understanding the role of inflammation and infection of the reproductive tract during pregnancy. We are particularly interested in understanding how vaginal microbiota and their interactions with the maternal host can influence poor pregnancy outcomes such as miscarriage, preterm premature rupture of membranes (PPROM) and preterm birth. This is achieved through a combination of classical biochemistry methods as well as “systems” modelling approaches that involve integration and analysis of genomic, transcriptomic, microbiomic and metabolic profiling data. It is hoped that will lead to improved diagnostic and predictive tools that will assist in patient stratification and ultimately, improved pregnancy outcomes.
Selected Publications
Journal Articles
Pruski P, Dos Santos Correia G, Lewis H, et al., 2021, Direct on-swab metabolic profiling of vaginal microbiome host interactions during pregnancy and preterm birth, Nature Communications, Vol:12, ISSN:2041-1723
Bonnardel F, Haslam SM, Dell A, et al., 2021, Proteome-wide prediction of bacterial carbohydrate-binding proteins as a tool for understanding commensal and pathogen colonisation of the vaginal microbiome, Npj Biofilms and Microbiomes, Vol:7, ISSN:2055-5008, Pages:1-10
Al-Memar M, Bobdiwala S, Fourie H, et al., 2020, The association between vaginal bacterial composition and miscarriage: a nested case-control study, BJOG - An International Journal of Obstetrics and Gynaecology, Vol:127, ISSN:1470-0328, Pages:264-274
Brown RG, Al-Memar M, Marchesi JR, et al., 2019, Establishment of vaginal microbiota composition in early pregnancy and its association with subsequent preterm prelabour rupture of the fetal membranes, Translational Research, Vol:207, ISSN:1931-5244, Pages:30-43