Dr Mann's lab is interested in cancer biology, particularly that relating to cell proliferation and signal transduction. Many cancers exhibit aberrant signal transduction and the enzymes involved can make excellent targets for therapeutic intervention. We aim to identify such targets, characterise their functions and establish techniques for regulating their activities. For more details, click the Research tab above.
Enquiries are always welcome from individuals interested in pursuing research within our group.
et al., 2021, Visualising G-quadruplex DNA dynamics in live cells by fluorescence lifetime imaging microscopy, Nature Communications, Vol:12, ISSN:2041-1723
Craven GB, Armstrong A, Mann DJ, 2020, Quantitative Irreversible Tethering (qIT) for Target-directed Covalent Fragment Screening, Bio-protocol, Vol:10
et al., 2020, Acrylamide Fragment Inhibitors that Induce Unprecedented Conformational Distortions in Enterovirus 71 3C and SARS-CoV-2 Main Protease
et al., 2020, Multiparameter kinetic analysis for covalent fragment optimization using quantitative irreversible tethering (qIT), Chembiochem: a European Journal of Chemical Biology, Vol:21, ISSN:1439-4227, Pages:3417-3422
et al., 2019, An octahedral cobalt(III) complex with axial NH3 ligands that templates and selectively stabilises G-quadruplex DNA, Chemistry - a European Journal, Vol:25, ISSN:0947-6539, Pages:9691-9700