Imperial College London

DrDavidMann

Faculty of Natural SciencesDepartment of Life Sciences

Reader in Cell Cycle Control
 
 
 
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Contact

 

+44 (0)20 7594 5302d.mann

 
 
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Location

 

605Sir Ernst Chain BuildingSouth Kensington Campus

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Summary

 

Summary

Research

Dr Mann's lab is interested in cancer biology, particularly that relating to cell proliferation and signal transduction. Many cancers exhibit aberrant signal transduction and the enzymes involved can make excellent targets for therapeutic intervention.  We aim to identify such targets, characterise their functions and establish techniques for regulating their activities.  For more details, click the Research tab above.

Enquiries

Enquiries are always welcome from individuals interested in pursuing research within our group.

Publications

Journals

Vilar R, Ruehl CL, Lim AHM, et al., 2019, An octahedral cobalt(III) complex with axial NH3 ligands that templates and selectively stabilises G-quadruplex DNA, Chemistry - a European Journal, ISSN:0947-6539

Craven G, Affron D, Raymond P, et al., 2019, Vinyl sulfonamide synthesis for irreversible tethering via a novel α-selenoether protection strategy, Medchemcomm, Vol:10, ISSN:2040-2503, Pages:158-163

Craven G, Affron D, Allen C, et al., 2018, High-throughput kinetic analysis for target-directed covalent ligand discovery, Angewandte Chemie, Vol:57, ISSN:1521-3757, Pages:5257-5261

Thinon E, Morales Sanfrutos J, Mann D, et al., 2016, N-Myristoyltransferase Inhibition Induces ER-Stress, Cell Cycle Arrest, and Apoptosis in Cancer Cells, Acs Chemical Biology, Vol:11, ISSN:1554-8937, Pages:2165-2176

Patents

Mann D, Armstrong A, Craven G, et al., 2018, (WO2018033753) ASSAY, PCT/GB2017/052456

More Publications