Dr Mann's lab is applying chemical biology techniques to cancer models, particularly those relating to cell proliferation and signal transduction. Many cancers exhibit aberrant signalling and the enzymes involved can make excellent targets for therapeutic intervention. We aim to generate chemical probes for key oncogenes and tumour suppressors to investigate their function and to act as starting points for therapeutic intervention. For more details, click the Research tab above.
Enquiries are always welcome from individuals interested in pursuing research within our group.
Hocking B, Armstrong A, Mann DJ, 2023, Covalent fragment libraries in drug discovery-Design, synthesis, and screening methods., Prog Med Chem, Vol:62, ISSN:0079-6468, Pages:105-146
et al., 2022, Acrylamide fragment inhibitors that induce unprecedented conformational distortions in enterovirus 71 3C and SARS-CoV-2 main protease, Acta Pharmaceutica Sinica B, Vol:12, ISSN:2211-3835, Pages:3924-3933
et al., 2021, Identification of the first structurally validated covalent ligands of the small GTPase RAB27A, Rsc Medicinal Chemistry, Vol:13, ISSN:2632-8682, Pages:150-155
et al., 2021, A genetically-encoded crosslinker screen identifies SERBP1 as a PKCε substrate influencing translation and cell division, Nature Communications, Vol:12
et al., 2021, Co-ordinated control of the Aurora B abscission checkpoint by PKCε complex assembly, midbody recruitment and retention, Biochemical Journal, Vol:478, ISSN:0264-6021, Pages:2247-2263