Publications
117 results found
Collins J, Mann DJ, Armstrong A, 2009, Discovery of a novel class of phosphatase inhibitors, RSC-SCI Medicinal Chemistry Symposium
Collins J, Mann DJ, Armstrong A, 2009, iscovery of a novel class of phosphatase inhibitor by virtual screening, QMUL Chemical Biology Symposium
McCague K, Armstrong A, Mann DJ, et al., 2009, Towards a New Technique for Identifying Substrates of Protein Kinases, 3rd Biological and Medicinal Chemistry Symposium
McCague K, Armstrong A, Mann DJ, et al., 2009, Towards a New Technique for Identifying Substrates of Protein Kinases, 1st RSC/SGC Chemical Biology for Drug Discovery Symposium
McCague K, Armstrong A, Mann DJ, et al., 2009, Towards a New Technique for Identifying Substrates of Protein Kinases, Pfizer Poster Symposium
McCague K, Armstrong A, Mann DJ, et al., 2009, Towards a New Technique for Identifying Substrates of Protein Kinases, 15TH RSC-SCI Medicinal Chemistry Symposium
McCague K, Armstrong A, Mann DJ, et al., 2009, Towards a New Technique for Identifying Substrates of Protein Kinases, Chemical Biology Symposium
Bishop RP, Odongo DO, Mann DJ, et al., 2009, Theileria, Genome Mapping and Genomics in Animal-Associated Microbes, Editors: Nene, Kole, Berlin Heidelberg, Germany, Publisher: Springer-Verlag, Pages: 191-231
Ho KK, Anderson AA, Rosivatz E, et al., 2008, Identification of cyclin A2 as the downstream effector of the nuclear phosphatidylinositol 4,5-bisphosphate signaling network, J.Biol.Chem., Vol: 283, Pages: 5477-5485
In addition to the well characterized phosphoinositide second messengers derived from the plasma membrane, increasing evidence supports the existence of a nuclear phosphoinositide signaling network. The aim of this investigation was to dissect the role played by nuclear phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) in cell cycle progression and to determine the cell cycle regulatory component(s) that are involved. A number of cytosolic/nuclear PtdIns(4,5)P2-deficient Swiss 3T3 cell lines were established, and their G 0/G 1/S cell cycle phase transitions induced by defined mitogens were examined. Our results demonstrate that nuclear PtdIns(4,5)P2 down-regulation caused a delay in phorbol ester-induced S phase entry and that this was at least in part channeled through cyclin A2 at the transcriptional level. In summary, these data identify cyclin A2 as a downstream effector of the nuclear PtdIns(4,5)P2 signaling network and highlight the importance of nuclear PtdIns(4,5)P2 in the regulation of mammalian mitogenesis
McCague K, Armstrong A, Mann DJ, et al., 2008, Identifying Protein Kinase Substrates using Chemical Genetics, RSC Bioorganic Chemistry and Chemical Biology Symposium
Elphick LM, Lee SE, Gouverneur V, et al., 2008, Dissecting Protein Kinase Function using ATP Analogues, BBSRC SCIBS Workshop
Yarmishyn A, Child ES, Elphick LM, et al., 2008, Differential regulation of the cyclin-dependent kinase inhibitors p21<SUP>Cip1</SUP> and p27<SUP>Kip1</SUP> by phosphorylation directed by the cyclin encoded by Murine Herpesvirus 68, EXPERIMENTAL CELL RESEARCH, Vol: 314, Pages: 204-212, ISSN: 0014-4827
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- Citations: 6
Brayton KA, Lau AOT, Herndon DR, et al., 2007, Genome sequence of babesia bovis and comparative analysis of apicomplexan hemoprotozoa, PLOS PATHOGENS, Vol: 3, Pages: 1401-1413, ISSN: 1553-7366
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- Citations: 310
Ohtani N, Imamura Y, Yamakoshi K, et al., 2007, Visualizing the dynamics of p21<SUP>Waf1/Cip1</SUP> cyclin-dependent kinase inhibitor expression in living animals, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 104, Pages: 15034-15039, ISSN: 0027-8424
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- Citations: 54
Elphick LM, Lee SE, Gouverneur V, et al., 2007, Using chemical genetics and ATP analogues to dissect protein kinase function, ACS CHEMICAL BIOLOGY, Vol: 2, Pages: 299-314, ISSN: 1554-8929
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- Citations: 52
McCague K, Armstrong A, Mann DJ, et al., 2007, Identifying Protein Kinase Substrates using Chemical Genetics, European Biophysics Congress Satellite Meeting
Elphick LM, Lee SE, Gouverneur V, et al., 2007, Dissecting Protein Kinase Function using Chemical Genetics and ATP Analogues, BBSRC SCIBS Workshop
Kowalski K, Suwaki N, Zakrzewski J, et al., 2007, <i>In vitro</i> DNA scission activity of heterometallocenes, DALTON TRANSACTIONS, Pages: 743-748, ISSN: 1477-9226
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- Citations: 17
Soeiro I, Mohamedali A, Romanska HM, et al., 2006, p27<SUP>Kip1</SUP> and p130 cooperate to regulate hematopoietic cell proliferation in vivo, MOLECULAR AND CELLULAR BIOLOGY, Vol: 26, Pages: 6170-6184, ISSN: 0270-7306
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- Citations: 15
Child ES, Mann DJ, 2006, The intricacies of p21 phosphorylation - Protein/protein interactions, subcellular localization and stability, CELL CYCLE, Vol: 5, Pages: 1313-1319, ISSN: 1538-4101
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- Citations: 148
Järviluoma A, Child ES, Sarek G, et al., 2006, Phosphorylation of the cyclin-dependent kinase inhibitor p21<SUP>Cip1</SUP> on serine 130 is essential for viral cyclin-mediated bypass of a p21<SUP>Cip1</SUP>-imposed G<sub>1</sub> arrest, MOLECULAR AND CELLULAR BIOLOGY, Vol: 26, Pages: 2430-2440, ISSN: 0270-7306
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- Citations: 43
Kowalski K, Zakrzewski J, Long NJ, et al., 2006, Synthesis, structure and assessment of the cytotoxic properties of 2,5-dimethylazaferrocenyl phosphonates, DALTON TRANSACTIONS, Pages: 571-576, ISSN: 1477-9226
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- Citations: 8
Yarmishyn A, Mann DJ, 2006, Properties of the cyclin encoded by Murine Herpesvirus 68, Cold Spring Harbor Cell Cycle Symposium
Suwaki N, Mann DJ, 2006, Potential role of cyclin D<sub>1</sub> in DNA damage response, Meeting on Breast Cancer Research - The Past and the Future, Publisher: BIOMED CENTRAL LTD, Pages: S8-S9, ISSN: 1465-5411
Gardner MJ, Bishop R, Shah T, et al., 2005, Genome sequence of <i>Theileria parva</i>, a bovine pathogen that transforms lymphocytes, SCIENCE, Vol: 309, Pages: 134-137, ISSN: 0036-8075
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- Citations: 261
Kinnaird JH, Bumstead JM, Mann DJ, et al., 2004, <i>EtCRK2</i>, a cyclin-dependent kinase gene expressed during the sexual and asexual phases of the <i>Eimeria tenella</i> life cycle, INTERNATIONAL JOURNAL FOR PARASITOLOGY, Vol: 34, Pages: 683-692, ISSN: 0020-7519
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- Citations: 24
Chopra S, de Mattos SF, Lam EWF, et al., 2002, Jab1 co-activation of c-Jun is abrogated by the serine 10-phosphorylated form of p27<SUP>Kip1</SUP>, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 277, Pages: 32413-32416, ISSN: 0021-9258
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- Citations: 22
Barnouin K, Dubuisson ML, Child ES, et al., 2002, H<sub>2</sub>O<sub>2</sub> induces a transient multi-phase cell cycle arrest in mouse fibroblasts through modulating cyclin D and p21<SUP>Cip1</SUP> expression, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 277, Pages: 13761-13770, ISSN: 0021-9258
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- Citations: 134
Child ES, Mann DJ, 2001, Novel properties of the cyclin encoded by Human Herpesvirus 8 that facilitate exit from quiescence, ONCOGENE, Vol: 20, Pages: 3311-3322, ISSN: 0950-9232
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- Citations: 33
Laman H, Mann DJ, Jones NC, 2000, Viral-encoded cyclins, CURRENT OPINION IN GENETICS & DEVELOPMENT, Vol: 10, Pages: 70-74, ISSN: 0959-437X
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- Citations: 26
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