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@article{Eccles:2013:10.1186/bcr3493,
author = {Eccles, SA and Aboagye, EO and Ali, S and Anderson, AS and Armes, J and Berditchevski, F and Blaydes, JP and Brennan, K and Brown, NJ and Bryant, HE and Bundred, NJ and Burchell, JM and Campbell, AM and Carroll, JS and Clarke, RB and Coles, CE and Cook, GJR and Cox, A and Curtin, NJ and Dekker, LV and dos, Santos Silva I and Duffy, SW and Easton, DF and Eccles, DM and Edwards, DR and Edwards, J and Evans, D and Fenlon, DF and Flanagan, JM and Foster, C and Gallagher, WM and Garcia-Closas, M and Gee, JMW and Gescher, AJ and Goh, V and Groves, AM and Harvey, AJ and Harvie, M and Hennessy, BT and Hiscox, S and Holen, I and Howell, SJ and Howell, A and Hubbard, G and Hulbert-Williams, N and Hunter, MS and Jasani, B and Jones, LJ and Key, TJ and Kirwan, CC and Kong, A and Kunkler, IH and Langdon, SP and Leach, MO and Mann, DJ and Marshall, JF and Martin, L and Martin, SG and Macdougall, JE and Miles, DW and Miller, WR and Morris, JR and Moss, SM and Mullan, P and Natrajan, R and OConnor, JP},
doi = {10.1186/bcr3493},
journal = {Breast Cancer Research},
pages = {R--R},
title = {Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer},
url = {http://dx.doi.org/10.1186/bcr3493},
volume = {15},
year = {2013}
}

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TY  - JOUR
AB  - IntroductionBreast cancer remains a significant scientific, clinical and societal challenge. This gap analysis has reviewed and critically assessed enduring issues and new challenges emerging from recent research, and proposes strategies for translating solutions into practice.MethodsMore than 100 internationally recognised specialist breast cancer scientists, clinicians and healthcare professionals collaborated to address nine thematic areas: genetics, epigenetics and epidemiology; molecular pathology and cell biology; hormonal influences and endocrine therapy; imaging, detection and screening; current/novel therapies and biomarkers; drug resistance; metastasis, angiogenesis, circulating tumour cells, cancer ‘stem’ cells; risk and prevention; living with and managing breast cancer and its treatment. The groups developed summary papers through an iterative process which, following further appraisal from experts and patients, were melded into this summary account.ResultsThe 10 major gaps identified were: (1) understanding the functions and contextual interactions of genetic and epigenetic changes in normal breast development and during malignant transformation; (2) how to implement sustainable lifestyle changes (diet, exercise and weight) and chemopreventive strategies; (3) the need for tailored screening approaches including clinically actionable tests; (4) enhancing knowledge of molecular drivers behind breast cancer subtypes, progression and metastasis; (5) understanding the molecular mechanisms of tumour heterogeneity, dormancy, de novo or acquired resistance and how to target key nodes in these dynamic processes; (6) developing validated markers for chemosensitivity and radiosensitivity; (7) understanding the optimal duration, sequencing and rational combinations of treatment for improved personalised therapy; (8) validating multimodality imaging biomarkers for minimally invasive diagnosis and monitoring of responses in primary and metastatic disease
AU  - Eccles,SA
AU  - Aboagye,EO
AU  - Ali,S
AU  - Anderson,AS
AU  - Armes,J
AU  - Berditchevski,F
AU  - Blaydes,JP
AU  - Brennan,K
AU  - Brown,NJ
AU  - Bryant,HE
AU  - Bundred,NJ
AU  - Burchell,JM
AU  - Campbell,AM
AU  - Carroll,JS
AU  - Clarke,RB
AU  - Coles,CE
AU  - Cook,GJR
AU  - Cox,A
AU  - Curtin,NJ
AU  - Dekker,LV
AU  - dos,Santos Silva I
AU  - Duffy,SW
AU  - Easton,DF
AU  - Eccles,DM
AU  - Edwards,DR
AU  - Edwards,J
AU  - Evans,D
AU  - Fenlon,DF
AU  - Flanagan,JM
AU  - Foster,C
AU  - Gallagher,WM
AU  - Garcia-Closas,M
AU  - Gee,JMW
AU  - Gescher,AJ
AU  - Goh,V
AU  - Groves,AM
AU  - Harvey,AJ
AU  - Harvie,M
AU  - Hennessy,BT
AU  - Hiscox,S
AU  - Holen,I
AU  - Howell,SJ
AU  - Howell,A
AU  - Hubbard,G
AU  - Hulbert-Williams,N
AU  - Hunter,MS
AU  - Jasani,B
AU  - Jones,LJ
AU  - Key,TJ
AU  - Kirwan,CC
AU  - Kong,A
AU  - Kunkler,IH
AU  - Langdon,SP
AU  - Leach,MO
AU  - Mann,DJ
AU  - Marshall,JF
AU  - Martin,L
AU  - Martin,SG
AU  - Macdougall,JE
AU  - Miles,DW
AU  - Miller,WR
AU  - Morris,JR
AU  - Moss,SM
AU  - Mullan,P
AU  - Natrajan,R
AU  - OConnor,JPB
AU  - OConnor,R
AU  - Palmieri,C
AU  - Pharoah,PDP
AU  - Rakha,EA
AU  - Reed,E
AU  - Robinson,SP
AU  - Sahai,E
AU  - Saxton,JM
AU  - Schmid,P
AU  - Smalley,MJ
AU  - Speirs,V
AU  - Stein,R
AU  - Stingl,J
AU  - Streuli,CH
AU  - Tutt,ANJ
AU  - Velikova,G
AU  - Walker,RA
AU  - Watson,CJ
AU  - Williams,KJ
AU  - Young,LS
AU  - Thompson,AM
DO  - 10.1186/bcr3493
PY  - 2013///
SN  - 1465-542X
TI  - Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer
T2  - Breast Cancer Research
UR  - http://dx.doi.org/10.1186/bcr3493
UR  - http://hdl.handle.net/10044/1/33445
VL  - 15
ER  -

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