Imperial College London
Alternate

DrDavidMann

Faculty of Natural Sciences, Department of Life Sciences

Reader in Cell Cycle Control
 
 
 
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Contact

 

+44 (0)20 7594 5302d.mann

 
 
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Location

 

605Sir Ernst Chain BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Child:2011:10.1007/s12154-011-0059-5,
author = {Child, ES and Georgiades, SN and Rose, KN and Stafford, VS and Patel, CBK and Steinke, JHG and Mann, DJ and Vilar, R},
doi = {10.1007/s12154-011-0059-5},
journal = {J Chem Biol},
pages = {159--165},
title = {Inhibition of mitogen-activated protein kinase (MAPK) and cyclin-dependent kinase 2 (Cdk2) by platinum(II) phenanthroline complexes.},
url = {http://dx.doi.org/10.1007/s12154-011-0059-5},
volume = {4},
year = {2011}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - UNLABELLED: Inhibition of protein kinases in the fight against disease remains a constant challenge for medicinal chemists, who have screened multitudes of predominantly planar organic scaffolds, natural and synthetic, to identify potent-albeit not always selective-kinase inhibitors. Herein, in an effort to investigate the potential biological utility of metal-based compounds as inhibitors against the cancer-relevant targets mitogen-activated protein kinase and cyclin-dependent kinase 2, we explore various parameters in planar platinum(II) complexes with substituted phenanthroline ligands and aliphatic diamine chelate co-ligands, to identify combinations that yield promising inhibitory activity. The individual ligands' steric requirements as well as their pattern of hydrogen bond donors/acceptors appear to alter inhibitory potency when modulated. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s12154-011-0059-5) contains supplementary material, which is available to authorized users.
AU  - Child,ES
AU  - Georgiades,SN
AU  - Rose,KN
AU  - Stafford,VS
AU  - Patel,CBK
AU  - Steinke,JHG
AU  - Mann,DJ
AU  - Vilar,R
DO  - 10.1007/s12154-011-0059-5
EP  - 165
PY  - 2011///
SP  - 159
TI  - Inhibition of mitogen-activated protein kinase (MAPK) and cyclin-dependent kinase 2 (Cdk2) by platinum(II) phenanthroline complexes.
T2  - J Chem Biol
UR  - http://dx.doi.org/10.1007/s12154-011-0059-5
UR  - https://www.ncbi.nlm.nih.gov/pubmed/22368708
VL  - 4
ER  -
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