Imperial College London
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Professor David W. McComb

Faculty of Engineering, Department of Materials

Adjunct Professor
 
 
 
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Contact

 

+44 (0)20 7594 6750d.mccomb Website

 
 
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Location

 

Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Liu:2021:10.1038/s41598-021-93513-0,
author = {Liu, Y and Feng, X and Liu, H and McComb, DW and Breuer, CK and Sacks, MS},
doi = {10.1038/s41598-021-93513-0},
journal = {Sci Rep},
title = {On the shape and structure of the murine pulmonary heart valve.},
url = {http://dx.doi.org/10.1038/s41598-021-93513-0},
volume = {11},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Murine animal models are an established standard in translational research and provides a potential platform for studying heart valve disease. To date, studies on heart valve disease using murine models have been hindered by a lack of appropriate methodologies due to their small scale. In the present study, we developed a multi-scale, imaging-based approach to extract the functional structure and geometry for the murine heart valve. We chose the pulmonary valve (PV) to study, due to its importance in congenital heart valve disease. Excised pulmonary outflow tracts from eleven 1-year old C57BL/6J mice were fixed at 10, 20, and 30 mmHg to simulate physiological loading. Micro-computed tomography was used to reconstruct the 3D organ-level PV geometry, which was then spatially correlated with serial en-face scanning electron microscopy imaging to quantify local collagen fiber distributions. From the acquired volume renderings, we obtained the geometric descriptors of the murine PV under increasing transvalvular pressures, which demonstrated remarkable consistency. Results to date suggest that the preferred collagen orientation was predominantly in the circumferential direction, as in larger mammalian valves. The present study represents a first step in establishing organ-level murine models for the study of heart valve disease.
AU  - Liu,Y
AU  - Feng,X
AU  - Liu,H
AU  - McComb,DW
AU  - Breuer,CK
AU  - Sacks,MS
DO  - 10.1038/s41598-021-93513-0
PY  - 2021///
TI  - On the shape and structure of the murine pulmonary heart valve.
T2  - Sci Rep
UR  - http://dx.doi.org/10.1038/s41598-021-93513-0
UR  - https://www.ncbi.nlm.nih.gov/pubmed/34234231
VL  - 11
ER  -
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