Imperial College London
Alternate

DrDeborahMorris-Rosendahl

Faculty of Medicine, National Heart & Lung Institute

Honorary Senior Research Fellow
 
 
 
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Contact

 

+44 (0)20 7351 8412d.morris-rosendahl

 
 
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Location

 

2091Royal BromptonRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Hoehe:2018:DCNS.2018.20.3/mhoehe,
author = {Hoehe, MR and Morris-Rosendahl, DJ},
doi = {DCNS.2018.20.3/mhoehe},
journal = {Dialogues in Clinical Neuroscience},
pages = {169--177},
title = {The role of genetics and genomics in clinical psychiatry},
url = {http://dx.doi.org/10.31887/DCNS.2018.20.3/mhoehe},
volume = {20},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The enormous successes in the genetics and genomics of many diseases have provided the basis for the advancement of precision medicine. Thus, the detection of genetic variants associated with neuropsychiatric disorders, as well as treatment outcome, has raised growing expectations that these findings could soon be translated into the clinic to improve diagnosis, the prediction of disease risk and individual response to drug therapy. In this article, we will provide an introduction to the search for genes involved in psychiatric illness and summarize the present findings in major psychiatric disorders. We will review the genetic variants in genes encoding drug metabolizing enzymes and specific drug targets which were found to be associated with variable drug response and severe side effects. We will evaluate the clinical translatability of these findings, whether there is currently any role for genetic testing and in this context, make valuable sources of information available to the clinician seeking guidance and advice in this rapidly developing field of psychiatric genetics.
AU  - Hoehe,MR
AU  - Morris-Rosendahl,DJ
DO  - DCNS.2018.20.3/mhoehe
EP  - 177
PY  - 2018///
SN  - 1294-8322
SP  - 169
TI  - The role of genetics and genomics in clinical psychiatry
T2  - Dialogues in Clinical Neuroscience
UR  - http://dx.doi.org/10.31887/DCNS.2018.20.3/mhoehe
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000456119400004&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://pubmed.ncbi.nlm.nih.gov/30581286/
UR  - http://hdl.handle.net/10044/1/91532
VL  - 20
ER  -
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