Imperial College London

Professor David Nutt DM, FRCP, FRCPsych, FSB, FMedSci

Faculty of MedicineDepartment of Medicine

The Edmond J Safra Chair in Neuropsychopharmacology
 
 
 
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Contact

 

d.nutt

 
 
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Location

 

Burlington Danes BuildingBurlington DanesHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

1250 results found

Heal DJ, Henningfield J, Frenguelli BG, Nutt DJ, Smith SLet al., 2018, Psychedelics - Re-opening the doors of perception, NEUROPHARMACOLOGY, Vol: 142, Pages: 1-6, ISSN: 0028-3908

JOURNAL ARTICLE

Rucker JJH, Iliff J, Nutt DJ, 2018, Psychiatry & the psychedelic drugs. Past, present & future, NEUROPHARMACOLOGY, Vol: 142, Pages: 200-218, ISSN: 0028-3908

JOURNAL ARTICLE

Timmermann C, Spriggs MJ, Kaelen M, Leech R, Nutt DJ, Moran RJ, Carhart-Harris RL, Muthukumaraswamy SDet al., 2018, LSD modulates effective connectivity and neural adaptation mechanisms in an auditory oddball paradigm, NEUROPHARMACOLOGY, Vol: 142, Pages: 251-262, ISSN: 0028-3908

JOURNAL ARTICLE

Roseman L, Demetriou L, Wall MB, Nutt DJ, Carhart-Harris RLet al., 2018, Increased amygdala responses to emotional faces after psilocybin for treatment-resistant depression, NEUROPHARMACOLOGY, Vol: 142, Pages: 263-269, ISSN: 0028-3908

JOURNAL ARTICLE

Horder J, Andersson M, Mendez MA, Singh N, Tangen A, Lundberg J, Gee A, Halldin C, Veronese M, Bolte S, Farde L, Sementa T, Cash D, Higgins K, Spain D, Turkheimer F, Mick I, Selvaraj S, Nutt DJ, Lingford-Hughes A, Howes OD, Murphy DG, Borg Jet al., 2018, GABA(A) receptor availability is not altered in adults with autism spectrum disorder or in mouse models, SCIENCE TRANSLATIONAL MEDICINE, Vol: 10, ISSN: 1946-6234

JOURNAL ARTICLE

Tyacke RJ, Myers JFM, Venkataraman A, Mick I, Turton S, Passchier J, Husbands SM, Rabiner EA, Gunn RN, Murphy PS, Parker CA, Nutt DJet al., 2018, Evaluation of C-11-BU99008, a PET Ligand for the Imidazoline(2) Binding Site in Human Brain, JOURNAL OF NUCLEAR MEDICINE, Vol: 59, Pages: 1597-1602, ISSN: 0161-5505

JOURNAL ARTICLE

Timmermann C, Roseman L, Williams L, Erritzoe D, Martial C, Cassol H, Laureys S, Nutt D, Carhart-Harris Ret al., 2018, DMT Models the Near-Death Experience, FRONTIERS IN PSYCHOLOGY, Vol: 9, ISSN: 1664-1078

JOURNAL ARTICLE

Rogeberg O, Blomkvist AW, Nutt D, 2018, CANNABIS AND OPIOID OVERDOSES: TIME TO MOVE ON AND EXAMINE POTENTIAL MECHANISMS, ADDICTION, Vol: 113, Pages: 1551-1552, ISSN: 0965-2140

JOURNAL ARTICLE

van den Brink W, Addolorato G, Aubin H-J, Benyamina A, Caputo F, Dematteis M, Gual A, Lesch O-M, Mann K, Maremmani I, Nutt D, Paille F, Perney P, Rehm J, Reynaud M, Simon N, Soederpalm B, Sommer WH, Walter H, Spanagel Ret al., 2018, Efficacy and safety of sodium oxybate in alcohol-dependent patients with a very high drinking risk level, ADDICTION BIOLOGY, Vol: 23, Pages: 969-986, ISSN: 1355-6215

JOURNAL ARTICLE

Turton S, Myers JF, Mick I, Colasanti A, Venkataraman A, Durant C, Waldman A, Brailsford A, Parkin MC, Dawe G, Rabiner EA, Gunn RN, Lightman SL, Nutt DJ, Lingford-Hughes Aet al., 2018, Blunted endogenous opioid release following an oral dexamphetamine challenge in abstinent alcohol-dependent individuals., Mol Psychiatry

Addiction has been proposed as a 'reward deficient' state, which is compensated for with substance use. There is growing evidence of dysregulation in the opioid system, which plays a key role in reward, underpinning addiction. Low levels of endogenous opioids are implicated in vulnerability for developing alcohol dependence (AD) and high mu-opioid receptor (MOR) availability in early abstinence is associated with greater craving. This high MOR availability is proposed to be the target of opioid antagonist medication to prevent relapse. However, changes in endogenous opioid tone in AD are poorly characterised and are important to understand as opioid antagonists do not help everyone with AD. We used [11C]carfentanil, a selective MOR agonist positron emission tomography (PET) radioligand, to investigate endogenous opioid tone in AD for the first time. We recruited 13 abstinent male AD and 15 control participants who underwent two [11C]carfentanil PET scans, one before and one 3 h following a 0.5 mg/kg oral dose of dexamphetamine to measure baseline MOR availability and endogenous opioid release. We found significantly blunted dexamphetamine-induced opioid release in 5 out of 10 regions-of-interest including insula, frontal lobe and putamen in AD compared with controls, but no significantly higher MOR availability AD participants compared with HC in any region. This study is comparable to our previous results of blunted dexamphetamine-induced opioid release in gambling disorder, suggesting that this dysregulation in opioid tone is common to both behavioural and substance addictions.

JOURNAL ARTICLE

Rogeberg O, Bergsvik D, Phillips LD, van Amsterdam J, Eastwood N, Henderson G, Lynskey M, Measham F, Ponton R, Rolles S, Schlag AK, Taylor P, Nutt Det al., 2018, A new approach to formulating and appraising drug policy: A multi-criterion decision analysis applied to alcohol and cannabis regulation, INTERNATIONAL JOURNAL OF DRUG POLICY, Vol: 56, Pages: 144-152, ISSN: 0955-3959

JOURNAL ARTICLE

Gabay AS, Carhart-Harris RL, Mazibuko N, Kempton MJ, Morrison PD, Nutt DJ, Mehta MAet al., 2018, Psilocybin and MDMA reduce costly punishment in the Ultimatum Game, SCIENTIFIC REPORTS, Vol: 8, ISSN: 2045-2322

JOURNAL ARTICLE

Kaelen M, Giribaldi B, Raine J, Evans L, Timmermann C, Rodriguez N, Roseman L, Feilding A, Nutt D, Carhart-Harris Ret al., 2018, The hidden therapist: evidence for a central role of music in psychedelic therapy (vol 235, pg 505, 2018), PSYCHOPHARMACOLOGY, Vol: 235, Pages: 1623-1623, ISSN: 0033-3158

JOURNAL ARTICLE

Carrillo F, Sigman M, Fernandez Slezak D, Ashton P, Fitzgerald L, Stroud J, Nutt DJ, Carhart-Harris RLet al., 2018, Natural speech algorithm applied to baseline interview data can predict which patients will respond to psilocybin for treatment-resistant depression, JOURNAL OF AFFECTIVE DISORDERS, Vol: 230, Pages: 84-86, ISSN: 0165-0327

JOURNAL ARTICLE

Dukart J, Holiga S, Chatham C, Hawkins P, Forsyth A, McMillan R, Myers J, Lingford-Hughes AR, Nutt DJ, Merlo-Pich E, Risterucci C, Boak L, Umbricht D, Schobel S, Liu T, Mehta MA, Zelaya FO, Williams SC, Brown G, Paulus M, Honey GD, Muthukumaraswamy S, Hipp J, Bertolino A, Sambataro Fet al., 2018, Cerebral blood flow predicts differential neurotransmitter activity, SCIENTIFIC REPORTS, Vol: 8, ISSN: 2045-2322

JOURNAL ARTICLE

Curran HV, Nutt D, de Wit H, 2018, Psychedelics and related drugs: therapeutic possibilities, mechanisms and regulation, PSYCHOPHARMACOLOGY, Vol: 235, Pages: 373-375, ISSN: 0033-3158

JOURNAL ARTICLE

Kaelen M, Giribaldi B, Raine J, Evans L, Timmerman C, Rodriguez N, Roseman L, Feilding A, Nutt D, Carhart-Harris Ret al., 2018, The hidden therapist: evidence for a central role of music in psychedelic therapy, PSYCHOPHARMACOLOGY, Vol: 235, Pages: 505-519, ISSN: 0033-3158

JOURNAL ARTICLE

Carhart-Harris RL, Bolstridge M, Day CMJ, Rucker J, Watts R, Erritzoe DE, Kaelen M, Giribaldi B, Bloomfield M, Pilling S, Rickard JA, Forbes B, Feilding A, Taylor D, Curran HV, Nutt DJet al., 2018, Psilocybin with psychological support for treatment-resistant depression: six-month follow-up, PSYCHOPHARMACOLOGY, Vol: 235, Pages: 399-408, ISSN: 0033-3158

JOURNAL ARTICLE

Stroud JB, Freeman TP, Leech R, Hindocha C, Lawn W, Nutt DJ, Curran HV, Carhart-Harris RLet al., 2018, Psilocybin with psychological support improves emotional face recognition in treatment-resistant depression, PSYCHOPHARMACOLOGY, Vol: 235, Pages: 459-466, ISSN: 0033-3158

JOURNAL ARTICLE

Roseman L, Nutt DJ, Carhart-Harris RL, 2018, Quality of Acute Psychedelic Experience Predicts Therapeutic Efficacy of Psilocybin for Treatment-Resistant Depression, FRONTIERS IN PHARMACOLOGY, Vol: 8, ISSN: 1663-9812

JOURNAL ARTICLE

Freeman TP, Pope RA, Wall MB, Bisby JA, Luijten M, Hindocha C, Mokrysz C, Lawn W, Moss A, Bloomfield MAP, Morgan CJA, Nutt DJ, Curran HVet al., 2018, Cannabis Dampens the Effects of Music in Brain Regions Sensitive to Reward and Emotion, INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, Vol: 21, Pages: 21-32, ISSN: 1461-1457

JOURNAL ARTICLE

Badiani A, Berridge KC, Heilig M, Nutt DJ, Robinson TEet al., 2018, Addiction research and theory: a commentary on the Surgeon General's Report on alcohol, drugs, and health, ADDICTION BIOLOGY, Vol: 23, Pages: 3-5, ISSN: 1355-6215

JOURNAL ARTICLE

Morris LS, Baek K, Tait R, Elliott R, Ersche KD, Flechais R, McGonigle J, Murphy A, Nestor LJ, Orban C, Passetti F, Paterson LM, Rabiner I, Reed L, Smith D, Suckling J, Taylor EM, Bullmore ET, Lingford-Hughes AR, Deakin B, Nutt DJ, Sahakian BJ, Robbins TW, Voon Vet al., 2018, Naltrexone ameliorates functional network abnormalities in alcohol-dependent individuals, ADDICTION BIOLOGY, Vol: 23, Pages: 425-436, ISSN: 1355-6215

JOURNAL ARTICLE

Mick I, Ramos AC, Myers J, Stokes PR, Chandrasekera S, Erritzoe D, Mendez MA, Gunn RN, Rabiner EA, Searle GE, Galduroz JCF, Waldman AD, Bowden-Jones H, Clark L, Nutt DJ, Lingford-Hughes ARet al., 2017, Evidence for GABA-A receptor dysregulation in gambling disorder: correlation with impulsivity, ADDICTION BIOLOGY, Vol: 22, Pages: 1601-1609, ISSN: 1355-6215

JOURNAL ARTICLE

Nestor LJ, Murphy A, McGonigle J, Orban C, Reed L, Taylor E, Flechais R, Paterson LM, Smith D, Bullmore ET, Ersche KD, Suckling J, Tait R, Elliott R, Deakin B, Rabiner I, Lingford-Hughes A, Nutt DJ, Sahakian B, Robbins TWet al., 2017, Acute naltrexone does not remediate fronto-striatal disturbances in alcoholic and alcoholic polysubstance-dependent populations during a monetary incentive delay task, ADDICTION BIOLOGY, Vol: 22, Pages: 1576-1589, ISSN: 1355-6215

JOURNAL ARTICLE

Davies B, Brown LA, Cais O, Watson J, Clayton AJ, Chang VT, Biggs D, Preece C, Hernandez-Pliego P, Krohn J, Bhomra A, Twigg SRF, Rimmer A, Kanapin A, Sen A, Zaiwalla Z, McVean G, Foster R, Donnelly P, Taylor JC, Blair E, Nutt D, Aricescu AR, Greger IH, Peirson SN, Flint J, Martin HCet al., 2017, A point mutation in the ion conduction pore of AMPA receptor GRIA3 causes dramatically perturbed sleep patterns as well as intellectual disability, HUMAN MOLECULAR GENETICS, Vol: 26, Pages: 3869-3882, ISSN: 0964-6906

JOURNAL ARTICLE

Carhart-Harris RL, Roseman L, Bolstridge M, Demetriou L, Pannekoek JN, Wall MB, Tanner M, Kaelen M, McGonigle J, Murphy K, Leech R, Curran HV, Nutt DJet al., 2017, Psilocybin for treatment-resistant depression: fMRI-measured brain mechanisms, SCIENTIFIC REPORTS, Vol: 7, ISSN: 2045-2322

JOURNAL ARTICLE

Andersson M, Horder J, Mendez M, Tangen A, Lundberg J, Gee A, Halldin C, Veronese M, Bolte S, Sementa T, Cash D, Turkheimer F, Mick S, Selvaraj S, Nutt D, Lingford-Hughes A, Howes O, Murphy D, Borg Jet al., 2017, A multicenter positron emission tomography study of GABA receptor availability in adults with autism, 30th Congress of the European-College-of-Neuropsychopharmacology (ECNP), Publisher: ELSEVIER SCIENCE BV, Pages: S716-S717, ISSN: 0924-977X

CONFERENCE PAPER

Walpola IC, Nest T, Roseman L, Erritzoe D, Feilding A, Nutt DJ, Carhart-Harris RLet al., 2017, Altered Insula Connectivity under MDMA, NEUROPSYCHOPHARMACOLOGY, Vol: 42, Pages: 2152-2162, ISSN: 0893-133X

JOURNAL ARTICLE

Quaglio G, Schellekens A, Blankers M, Hoch E, Karapiperis T, Esposito G, Brand H, Nutt D, Kiefer Fet al., 2017, A Brief Outline of the Use of New Technologies for Treating Substance Use Disorders in the European Union, EUROPEAN ADDICTION RESEARCH, Vol: 23, Pages: 177-181, ISSN: 1022-6877

JOURNAL ARTICLE

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