Imperial College London

Professor David Nutt DM, FRCP, FRCPsych, FSB, FMedSci

Faculty of MedicineDepartment of Brain Sciences

The Edmond J Safra Chair in Neuropsychopharmacology
 
 
 
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Contact

 

d.nutt

 
 
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Location

 

Burlington Danes BuildingBurlington DanesHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

1332 results found

Carhart-Harris RL, Nutt DJ, 2013, Experienced Drug Users Assess the Relative Harms and Benefits of Drugs: A Web-Based Survey, JOURNAL OF PSYCHOACTIVE DRUGS, Vol: 45, Pages: 322-328, ISSN: 0279-1072

Journal article

Fineberg NA, Haddad PM, Carpenter L, Gannon B, Sharpe R, Young AH, Joyce E, Rowe J, Wellsted D, Nutt DJ, Sahakian BJet al., 2013, The size, burden and cost of disorders of the brain in the UK, JOURNAL OF PSYCHOPHARMACOLOGY, Vol: 27, Pages: 761-770, ISSN: 0269-8811

Journal article

Emsley E, Lees R, Lingford-Hughes A, Nutt Det al., 2013, Annual General Meeting of the British NeuroPsychiatry Association, London, England, February 7-8, 2013 Abstracts, JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol: 84, ISSN: 0022-3050

Journal article

Carhart-Harris RL, Brugger S, Nutt DJ, Stone JMet al., 2013, Psychiatry's next top model: cause for a re-think on drug models of psychosis and other psychiatric disorders, JOURNAL OF PSYCHOPHARMACOLOGY, Vol: 27, Pages: 771-778, ISSN: 0269-8811

Journal article

Colasanti A, Lingford-Hughes A, Nutt D, 2013, Opioids Neuroimaging, Biological Research on Addiction, Pages: 675-687, ISBN: 9780123983350

Book chapter

Nutt DJ, McAllister-Williams RH, 2013, Noradrenaline - the forgotten amine?, JOURNAL OF PSYCHOPHARMACOLOGY, Vol: 27, Pages: 657-658, ISSN: 0269-8811

Journal article

Nutt D, Gispen-de Wied CC, Arango C, Keefe RSE, Penades R, Murphy DG, Robbins TW, Sahakian BJet al., 2013, Cognition in schizophrenia: Summary Nice Consultation Meeting 2012, EUROPEAN NEUROPSYCHOPHARMACOLOGY, Vol: 23, Pages: 769-778, ISSN: 0924-977X

Journal article

Nutt DJ, King LA, Nichols DE, 2013, Effects of Schedule I drug laws on neuroscience research and treatment innovation, NATURE REVIEWS NEUROSCIENCE, Vol: 14, Pages: 577-585, ISSN: 1471-003X

Journal article

Stuart SA, Butler P, Munafo MR, Nutt DJ, Robinson ESJet al., 2013, A Translational Rodent Assay of Affective Biases in Depression and Antidepressant Therapy, NEUROPSYCHOPHARMACOLOGY, Vol: 38, Pages: 1625-1635, ISSN: 0893-133X

Journal article

Toru I, Maron E, Raag M, Vasar V, Nutt DJ, Shlik Jet al., 2013, The effect of 6-week treatment with escitalopram on CCK-4 challenge: A placebo-controlled study in CCK-4-sensitive healthy volunteers, EUROPEAN NEUROPSYCHOPHARMACOLOGY, Vol: 23, Pages: 645-652, ISSN: 0924-977X

Journal article

Green A, Crawford A, Lewis G, Wiles N, Peters T, Nutt Det al., 2013, Are baseline physical symptoms characteristic of severe depression or a poor prognostic factor? Secondary analysis of the GenPod trial, JOURNAL OF PSYCHOSOMATIC RESEARCH, Vol: 74, Pages: 546-546, ISSN: 0022-3999

Journal article

Nutt D, 2013, Addiction: lifestyle choice or medical diagnosis?, JOURNAL OF EVALUATION IN CLINICAL PRACTICE, Vol: 19, Pages: 493-496, ISSN: 1356-1294

Journal article

Heal DJ, Smith SL, Gosden J, Nutt DJet al., 2013, Amphetamine, past and present - a pharmacological and clinical perspective, JOURNAL OF PSYCHOPHARMACOLOGY, Vol: 27, Pages: 479-496, ISSN: 0269-8811

Journal article

Muthukumaraswamy SD, Myers JFM, Wilson SJ, Nutt DJ, Hamandi K, Lingford-Hughes A, Singh KDet al., 2013, Elevating Endogenous GABA Levels with GAT-1 Blockade Modulates Evoked but Not Induced Responses in Human Visual Cortex, NEUROPSYCHOPHARMACOLOGY, Vol: 38, Pages: 1105-1112, ISSN: 0893-133X

Journal article

Mendez MA, Horder J, Myers J, Coghlan S, Stokes P, Erritzoe D, Howes O, Lingford-Hughes A, Murphy D, Nutt Det al., 2013, The brain GABA-benzodiazepine receptor alpha-5 subtype in autism spectrum disorder: A pilot [C-11]Ro15-4513 positron emission tomography study, NEUROPHARMACOLOGY, Vol: 68, Pages: 195-201, ISSN: 0028-3908

Journal article

Stokes PRA, Benecke A, Myers J, Erritzoe D, Watson B, Kalk N, Riano Barros D, Hammers A, Nutt D, Lingford-Hughes ARet al., 2013, History of cigarette smoking is associated with higher limbic GABAA receptor availability, Neuroimage, Vol: 69, Pages: 70-77

Cigarette smoking presents a significant worldwide healthcare challenge. Preclinical, genetic association and clinical trials studies provide considerable evidence for the involvement of the human γ-aminobutyric acid (GABA) system in the neurobiology of nicotine addiction. However there are few human GABA neurochemical imaging studies of nicotine addiction. We investigated limbic GABAA receptor availability in volunteers with a history of cigarette smoking using [11C]Ro15 4513 positron emission tomography (PET). Eight [11C]Ro15 4513 PET scans from volunteers with a history of cigarette smoking were compared to twelve scans from volunteers who were non-smokers. Total, α1 and α5 GABAA receptor subtype [11C]Ro15 4513 VT values were quantified using spectral analysis of limbic regions implicated in nicotine addiction. Spectral analysis allows quantification of the overall [11C]Ro15 4513 spectral frequency as well as α1 and α5 GABAA receptor subtype specific spectral frequency components. Volunteers with a history of cigarette smoking showed significantly higher total [11C]Ro15 4513 VT values in the presubgenual cingulate and parahippocampal gyrus, and at a trend level in the insula, nucleus accumbens and subgenual cingulate. In six abstinent previous smokers (‘ex-smokers’), total [11C]Ro15 4513 binding was significantly higher in all limbic regions studied, with higher α5 availability in the amygdala, anterior cingulate, nucleus accumbens and presubgenual cingulate. These results suggest that limbic GABAA receptor availability is higher in volunteers with a history of cigarette smoking which may reflect either higher expression of GABAA receptors or lower endogenous GABA levels. The findings in ex-smokers suggest that higher GABAA receptor availability continues with abstinence indicating that this may be a trait marker for nicotine addiction or that alterations in GABA function associated with cigarette smoking persist.

Journal article

van Amsterdam J, Nutt D, van den Brink W, 2013, Generic legislation of new psychoactive drugs, JOURNAL OF PSYCHOPHARMACOLOGY, Vol: 27, Pages: 317-324, ISSN: 0269-8811

Journal article

Kalk NJ, Guo Q, Cherian R, Erritzoe D, Waldman A, Dar K, Gunn RN, Nutt DJ, Rabiner EA, Lingford-Hughes ARet al., 2013, Using positron emission tomography to investigate microglial activation in alcohol dependence: preliminary findings, EUROPEAN NEUROPSYCHOPHARMACOLOGY, Vol: 23, Pages: S87-S88, ISSN: 0924-977X

Journal article

Green A, Kaul A, O'Shea J, Sharma E, Bennett L, Mullings EL, Munafo MR, Nutt DJ, Melichar JK, Donaldson LFet al., 2013, Opiate agonists and antagonists modulate taste perception in opiate-maintained and recently detoxified subjects, JOURNAL OF PSYCHOPHARMACOLOGY, Vol: 27, Pages: 265-275, ISSN: 0269-8811

Journal article

Muthukumaraswamy SD, Myers JFM, Wilson SJ, Nutt DJ, Lingford-Hughes A, Singh KD, Hamandi Ket al., 2013, The effects of elevated endogenous GABA levels on movement-related network oscillations, NEUROIMAGE, Vol: 66, Pages: 36-41, ISSN: 1053-8119

Journal article

Owen DR, Rupprecht R, Nutt DJ, 2013, Stratified medicine in psychiatry: a worrying example or new opportunity in the treatment of anxiety?, JOURNAL OF PSYCHOPHARMACOLOGY, Vol: 27, Pages: 119-122, ISSN: 0269-8811

Journal article

Diaper A, Osman-Hicks V, Rich AS, Craig K, Dourish CT, Dawson GR, Nutt DJ, Bailey JEet al., 2013, Evaluation of the effects of venlafaxine and pregabalin on the carbon dioxide inhalation models of Generalised Anxiety Disorder and panic, JOURNAL OF PSYCHOPHARMACOLOGY, Vol: 27, Pages: 135-145, ISSN: 0269-8811

Journal article

Diaper A, Nutt DJ, Munafo MR, White JL, Farmer EW, Bailey JEet al., 2013, Effects of 7.5% CO2-Induced Anxiety on Individual Performance During a Group Computer Combat Game, MILITARY PSYCHOLOGY, Vol: 25, Pages: 615-622, ISSN: 0899-5605

Journal article

Heal DJ, Smith SL, Gosden J, Nutt DJet al., 2013, Amphetamine, past and present - a pharmacological and clinical perspective, JOURNAL OF PSYCHOPHARMACOLOGY, Vol: 27, Pages: 479-496, ISSN: 0269-8811

Journal article

Hyman S, Volkow N, Nutt D, 2013, Pharmacological cognitive enhancement in healthy people: Potential and concerns, NEUROPHARMACOLOGY, Vol: 64, Pages: 8-12, ISSN: 0028-3908

Journal article

Kealey S, Turner EM, Husbands SM, Salinas CA, Jakobsen S, Tyacke RJ, Nutt DJ, Parker CA, Gee ADet al., 2013, Imaging Imidazoline-I-2 Binding Sites in Porcine Brain Using C-11-BU99008, JOURNAL OF NUCLEAR MEDICINE, Vol: 54, Pages: 139-144, ISSN: 0161-5505

Journal article

Paterson LM, Kornum BR, Nutt DJ, Pike VW, Knudsen GMet al., 2013, 5-HT radioligands for human brain imaging with PET and SPECT, MEDICINAL RESEARCH REVIEWS, Vol: 33, Pages: 54-111, ISSN: 0198-6325

Journal article

Owen D, Guo Q, Colasanti A, Kalk N, Kalogiannopoulou D, Libri V V, Lewis Y, Matthews PM, Gunn R, Rabiner Eet al., 2013, Determination of [11C]PBR28 binding potential in vivo: A first human TSPO occupancy study.

Journal article

Baldwin DS, Nutt DJ, 2012, On assessing potential efficacy for vortioxetine in generalized anxiety disorder, EUROPEAN NEUROPSYCHOPHARMACOLOGY, Vol: 22, Pages: 841-843, ISSN: 0924-977X

Journal article

Maron E, Nutt D, Shlik J, 2012, Neuroimaging of Serotonin System in Anxiety Disorders, CURRENT PHARMACEUTICAL DESIGN, Vol: 18, Pages: 5699-5708, ISSN: 1381-6128

Journal article

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