Professor David Nutt DM, FRCP, FRCPsych, FSB, FMedSci

Fineberg NA, Haddad PM, Carpenter L, Gannon B, Sharpe R, Young AH, Joyce E, Rowe J, Wellsted D, Nutt DJ, Sahakian BJet al., 2013, The size, burden and cost of disorders of the brain in the UK, JOURNAL OF PSYCHOPHARMACOLOGY, Vol: 27, Pages: 761-770, ISSN: 0269-8811

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• Citations: 114

Rehm J, Marmet S, Anderson P, Gual A, Kraus L, Nutt DJ, Room R, Samokhvalov AV, Scafato E, Trapencieris M, Wiers RW, Gmel Get al., 2013, Defining Substance Use Disorders: Do We Really Need More Than Heavy Use?, ALCOHOL AND ALCOHOLISM, Vol: 48, Pages: 633-640, ISSN: 0735-0414

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• Citations: 157

Nutt DJ, McAllister-Williams RH, 2013, Noradrenaline - the forgotten amine?, JOURNAL OF PSYCHOPHARMACOLOGY, Vol: 27, Pages: 657-658, ISSN: 0269-8811

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• Citations: 1

Nutt D, Gispen-de Wied CC, Arango C, Keefe RSE, Penades R, Murphy DG, Robbins TW, Sahakian BJet al., 2013, Cognition in schizophrenia: Summary Nice Consultation Meeting 2012, EUROPEAN NEUROPSYCHOPHARMACOLOGY, Vol: 23, Pages: 769-778, ISSN: 0924-977X

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• Citations: 6

Nutt DJ, King LA, Nichols DE, 2013, Effects of Schedule I drug laws on neuroscience research and treatment innovation, NATURE REVIEWS NEUROSCIENCE, Vol: 14, Pages: 577-585, ISSN: 1471-003X

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• Citations: 191

Stuart SA, Butler P, Munafo MR, Nutt DJ, Robinson ESJet al., 2013, A Translational Rodent Assay of Affective Biases in Depression and Antidepressant Therapy, NEUROPSYCHOPHARMACOLOGY, Vol: 38, Pages: 1625-1635, ISSN: 0893-133X

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• Citations: 68

Toru I, Maron E, Raag M, Vasar V, Nutt DJ, Shlik Jet al., 2013, The effect of 6-week treatment with escitalopram on CCK-4 challenge: A placebo-controlled study in CCK-4-sensitive healthy volunteers, EUROPEAN NEUROPSYCHOPHARMACOLOGY, Vol: 23, Pages: 645-652, ISSN: 0924-977X

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• Citations: 7

Green A, Crawford A, Lewis G, Wiles N, Peters T, Nutt Det al., 2013, Are baseline physical symptoms characteristic of severe depression or a poor prognostic factor? Secondary analysis of the GenPod trial, JOURNAL OF PSYCHOSOMATIC RESEARCH, Vol: 74, Pages: 546-546, ISSN: 0022-3999

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• Citations: 1

Heal DJ, Smith SL, Gosden J, Nutt DJet al., 2013, Amphetamine, past and present - a pharmacological and clinical perspective, JOURNAL OF PSYCHOPHARMACOLOGY, Vol: 27, Pages: 479-496, ISSN: 0269-8811

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• Citations: 279

Nutt D, 2013, Addiction: lifestyle choice or medical diagnosis?, JOURNAL OF EVALUATION IN CLINICAL PRACTICE, Vol: 19, Pages: 493-496, ISSN: 1356-1294

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• Citations: 7

Mendez MA, Horder J, Myers J, Coghlan S, Stokes P, Erritzoe D, Howes O, Lingford-Hughes A, Murphy D, Nutt Det al., 2013, The brain GABA-benzodiazepine receptor alpha-5 subtype in autism spectrum disorder: A pilot [<SUP>11</SUP>C]Ro15-4513 positron emission tomography study, NEUROPHARMACOLOGY, Vol: 68, Pages: 195-201, ISSN: 0028-3908

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• Citations: 75

Nabulsi N, Holden D, Lin S-F, Labaree D, Cass T, Kapinos M, Ropchan J, Tyacke RJ, Parker CA, Nutt DJ, Carson RE, Huang Yet al., 2013, PET imaging of the imadazoline-2 binding sites: Evaluation of the novel radiotracer [<SUP>11</SUP>C]BU99008 in non-human primates, JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, Vol: 56, Pages: S58-S58, ISSN: 0362-4803

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Muthukumaraswamy SD, Myers JFM, Wilson SJ, Nutt DJ, Hamandi K, Lingford-Hughes A, Singh KDet al., 2013, Elevating Endogenous GABA Levels with GAT-1 Blockade Modulates Evoked but Not Induced Responses in Human Visual Cortex, NEUROPSYCHOPHARMACOLOGY, Vol: 38, Pages: 1105-1112, ISSN: 0893-133X

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• Citations: 27

Stokes PRA, Benecke A, Myers J, Erritzoe D, Watson B, Kalk N, Riano Barros D, Hammers A, Nutt D, Lingford-Hughes ARet al., 2013, History of cigarette smoking is associated with higher limbic GABAA receptor availability, Neuroimage, Vol: 69, Pages: 70-77

Cigarette smoking presents a significant worldwide healthcare challenge. Preclinical, genetic association and clinical trials studies provide considerable evidence for the involvement of the human γ-aminobutyric acid (GABA) system in the neurobiology of nicotine addiction. However there are few human GABA neurochemical imaging studies of nicotine addiction. We investigated limbic GABAA receptor availability in volunteers with a history of cigarette smoking using [11C]Ro15 4513 positron emission tomography (PET). Eight [11C]Ro15 4513 PET scans from volunteers with a history of cigarette smoking were compared to twelve scans from volunteers who were non-smokers. Total, α1 and α5 GABAA receptor subtype [11C]Ro15 4513 VT values were quantified using spectral analysis of limbic regions implicated in nicotine addiction. Spectral analysis allows quantification of the overall [11C]Ro15 4513 spectral frequency as well as α1 and α5 GABAA receptor subtype specific spectral frequency components. Volunteers with a history of cigarette smoking showed significantly higher total [11C]Ro15 4513 VT values in the presubgenual cingulate and parahippocampal gyrus, and at a trend level in the insula, nucleus accumbens and subgenual cingulate. In six abstinent previous smokers (‘ex-smokers’), total [11C]Ro15 4513 binding was significantly higher in all limbic regions studied, with higher α5 availability in the amygdala, anterior cingulate, nucleus accumbens and presubgenual cingulate. These results suggest that limbic GABAA receptor availability is higher in volunteers with a history of cigarette smoking which may reflect either higher expression of GABAA receptors or lower endogenous GABA levels. The findings in ex-smokers suggest that higher GABAA receptor availability continues with abstinence indicating that this may be a trait marker for nicotine addiction or that alterations in GABA function associated with cigarette smoking persist.

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Green A, Kaul A, O'Shea J, Sharma E, Bennett L, Mullings EL, Munafo MR, Nutt DJ, Melichar JK, Donaldson LFet al., 2013, Opiate agonists and antagonists modulate taste perception in opiate-maintained and recently detoxified subjects, JOURNAL OF PSYCHOPHARMACOLOGY, Vol: 27, Pages: 265-275, ISSN: 0269-8811

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• Citations: 19

Kalk NJ, Guo Q, Cherian R, Erritzoe D, Waldman A, Dar K, Gunn RN, Nutt DJ, Rabiner EA, Lingford-Hughes ARet al., 2013, Using positron emission tomography to investigate microglial activation in alcohol dependence: preliminary findings, EUROPEAN NEUROPSYCHOPHARMACOLOGY, Vol: 23, Pages: S87-S88, ISSN: 0924-977X

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van Amsterdam J, Nutt D, van den Brink W, 2013, Generic legislation of new psychoactive drugs, JOURNAL OF PSYCHOPHARMACOLOGY, Vol: 27, Pages: 317-324, ISSN: 0269-8811

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• Citations: 38

Muthukumaraswamy SD, Myers JFM, Wilson SJ, Nutt DJ, Lingford-Hughes A, Singh KD, Hamandi Ket al., 2013, The effects of elevated endogenous GABA levels on movement-related network oscillations, NEUROIMAGE, Vol: 66, Pages: 36-41, ISSN: 1053-8119

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• Citations: 124

Diaper A, Osman-Hicks V, Rich AS, Craig K, Dourish CT, Dawson GR, Nutt DJ, Bailey JEet al., 2013, Evaluation of the effects of venlafaxine and pregabalin on the carbon dioxide inhalation models of Generalised Anxiety Disorder and panic, JOURNAL OF PSYCHOPHARMACOLOGY, Vol: 27, Pages: 135-145, ISSN: 0269-8811

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• Citations: 10

Owen DR, Rupprecht R, Nutt DJ, 2013, Stratified medicine in psychiatry: a worrying example or new opportunity in the treatment of anxiety?, JOURNAL OF PSYCHOPHARMACOLOGY, Vol: 27, Pages: 119-122, ISSN: 0269-8811

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• Citations: 13

Heal DJ, Smith SL, Gosden J, Nutt DJet al., 2013, Amphetamine, past and present - a pharmacological and clinical perspective, JOURNAL OF PSYCHOPHARMACOLOGY, Vol: 27, Pages: 479-496, ISSN: 0269-8811

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Kealey S, Turner EM, Husbands SM, Salinas CA, Jakobsen S, Tyacke RJ, Nutt DJ, Parker CA, Gee ADet al., 2013, Imaging Imidazoline-I₂ Binding Sites in Porcine Brain Using <SUP>11</SUP>C-BU99008, JOURNAL OF NUCLEAR MEDICINE, Vol: 54, Pages: 139-144, ISSN: 0161-5505

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• Citations: 29

Hyman S, Volkow N, Nutt D, 2013, Pharmacological cognitive enhancement in healthy people: Potential and concerns, NEUROPHARMACOLOGY, Vol: 64, Pages: 8-12, ISSN: 0028-3908

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Paterson LM, Kornum BR, Nutt DJ, Pike VW, Knudsen GMet al., 2013, 5-HT radioligands for human brain imaging with PET and SPECT, MEDICINAL RESEARCH REVIEWS, Vol: 33, Pages: 54-111, ISSN: 0198-6325

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• Citations: 108

Colasanti A, Lingford-Hughes A, Nutt D, 2013, Opioids Neuroimaging, BIOLOGICAL RESEARCH ON ADDICTION: COMPREHENSIVE ADDICTIVE BEHAVIORS AND DISORDERS, VOL 2, Editors: Miller, Publisher: ELSEVIER ACADEMIC PRESS INC, Pages: 675-687

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• Citations: 2

Owen D, Guo Q, Colasanti A, Kalk N, Kalogiannopoulou D, Libri V V, Lewis Y, Matthews PM, Gunn R, Rabiner Eet al., 2013, Determination of [11C]PBR28 binding potential in vivo: A first human TSPO occupancy study.

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Diaper A, Nutt DJ, Munafo MR, White JL, Farmer EW, Bailey JEet al., 2013, Effects of 7.5% CO₂-Induced Anxiety on Individual Performance During a Group Computer Combat Game, MILITARY PSYCHOLOGY, Vol: 25, Pages: 615-622, ISSN: 0899-5605

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• Citations: 4

Nutt DJ, Ogren SO, van Ree JM, 2012, Neuropsychopharmacology across brain diseases, EUROPEAN NEUROPSYCHOPHARMACOLOGY, Vol: 22, Pages: 844-846, ISSN: 0924-977X

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Quelch DR, Parker CA, Nutt DJ, Tyacke RJ, Erritzoe Det al., 2012, Influence of different cellular environments on [3H]DASB radioligand binding, SYNAPSE, Vol: 66, Pages: 1035-1039, ISSN: 0887-4476

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• Citations: 16

Maron E, Nutt D, Shlik J, 2012, Neuroimaging of Serotonin System in Anxiety Disorders, CURRENT PHARMACEUTICAL DESIGN, Vol: 18, Pages: 5699-5708, ISSN: 1381-6128

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• Citations: 25