Imperial College London
Alternate

Professor David Nutt DM, FRCP, FRCPsych, FSB, FMedSci

Faculty of Medicine, Department of Brain Sciences

The Edmond J Safra Chair in Neuropsychopharmacology
 
 
 
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Contact

 

d.nutt

 
 
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Location

 

Burlington Danes BuildingBurlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Timmermann:2019:10.1038/s41598-019-51974-4,
author = {Timmermann, Slater CB and Roseman, L and Schartner, M and Milliere, R and Williams, L and Erritzoe, D and Muthukumaraswamy, S and Ashton, M and Bendrioua, A and Kaur, O and Turton, S and Nour, M and Day, C and Leech, R and Nutt, D and Carhart-Harris, R},
doi = {10.1038/s41598-019-51974-4},
journal = {Scientific Reports},
pages = {1--13},
title = {Neural correlates of the DMT experience as assessed with multivariate EEG},
url = {http://dx.doi.org/10.1038/s41598-019-51974-4},
volume = {9},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Studying transitions in and out of the altered state of consciousness caused by intravenous (IV) N,N-Dimethyltryptamine (DMT - a fast-acting tryptamine psychedelic) offers a safe and powerful means of advancing knowledge on the neurobiology of conscious states. Here we sought to investigate the effects of IV DMT on the power spectrum and signal diversity of human brain activity (6 female, 7 male) recorded via multivariate EEG, and plot relationships between subjective experience, brain activity and drug plasma concentrations across time. Compared with placebo, DMT markedly reduced oscillatory power in the alpha and beta bands and robustly increased spontaneous signal diversity. Time-referenced neurophenomenological analyses revealed close relationships between changes in various aspects of subjective experience and changes in brain activity. Importantly, the emergence of oscillatory activity within the delta and theta frequency bands was found to correlate with the peak of the experience - particularly its eyes-closed visual component. These findings highlight marked changes in oscillatory activity and signal diversity with DMT that parallel broad and specific components of the subjective experience, thus advancing our understanding of the neurobiological underpinnings of immersive states of consciousness.
AU  - Timmermann,Slater CB
AU  - Roseman,L
AU  - Schartner,M
AU  - Milliere,R
AU  - Williams,L
AU  - Erritzoe,D
AU  - Muthukumaraswamy,S
AU  - Ashton,M
AU  - Bendrioua,A
AU  - Kaur,O
AU  - Turton,S
AU  - Nour,M
AU  - Day,C
AU  - Leech,R
AU  - Nutt,D
AU  - Carhart-Harris,R
DO  - 10.1038/s41598-019-51974-4
EP  - 13
PY  - 2019///
SN  - 2045-2322
SP  - 1
TI  - Neural correlates of the DMT experience as assessed with multivariate EEG
T2  - Scientific Reports
UR  - http://dx.doi.org/10.1038/s41598-019-51974-4
UR  - https://www.nature.com/articles/s41598-019-51974-4
UR  - http://hdl.handle.net/10044/1/74395
VL  - 9
ER  -
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