Imperial College London
Alternate

Professor David Nutt DM, FRCP, FRCPsych, FSB, FMedSci

Faculty of Medicine, Department of Brain Sciences

The Edmond J Safra Chair in Neuropsychopharmacology
 
 
 
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Contact

 

d.nutt

 
 
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Location

 

Burlington Danes BuildingBurlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Mick:2016:10.1111/adb.12457,
author = {Mick, I and Ramos, C and Myers, J and Stokes, P and Chandrasekera1, S and Erritzoe, D and Mendez, M and Gunn, R and Rabiner, E and Searle, G and Galduróz, J and Waldman, A and Bowden-Jones, H and Clark, L and Nutt, D and Lingford-Hughes, AR},
doi = {10.1111/adb.12457},
journal = {Addiction Biology},
pages = {1601--1609},
title = {Evidence for GABA-A receptor dysregulation in gambling disorder: correlation with impulsivity.},
url = {http://dx.doi.org/10.1111/adb.12457},
volume = {22},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background: As a behavioral addiction, gambling disorder (GD) provides an opportunity to characterize addictive processes without the potentially confounding effects of chronic excessive drug and alcohol exposure. Impulsivity is an established precursor to such addictive behaviours and GD is associated with greater impulsivity. There is also evidence of GABAergic dysregulation in substance addiction and in impulsivity. Methods: This study therefore investigated GABAA receptor availability in 15 individuals with GD and 19 healthy volunteers (HV) using [11C]Ro15-4513, a relatively selective α5 benzodiazepine receptor PET tracer and its relationship with impulsivity. Results: We found significantly higher [11C]Ro15-4513 total distribution volume (VT) in the right hippocampus in the GD group compared with HV. We found higher levels of The ‘Negative Urgency’ construct of impulsivity in GD and these were positively associated with higher [11C]Ro15-4513 VT in the amygdala in the GD group; no such significant correlations were evident in the HV group. Conclusions: These results contrast with reduced binding of GABAergic PET ligands described previously in alcohol and opiate addiction and add to growing evidence for distinctions in the neuropharmacology between substance and behavioral addictions. These results provide the first characterization of GABAA receptors in GD with [11C]Ro15-4513 PET and show greater α5 receptor availability and positive correlations with trait impulsivity. This GABAergic dysregulation is potential target for treatment.
AU  - Mick,I
AU  - Ramos,C
AU  - Myers,J
AU  - Stokes,P
AU  - Chandrasekera1,S
AU  - Erritzoe,D
AU  - Mendez,M
AU  - Gunn,R
AU  - Rabiner,E
AU  - Searle,G
AU  - Galduróz,J
AU  - Waldman,A
AU  - Bowden-Jones,H
AU  - Clark,L
AU  - Nutt,D
AU  - Lingford-Hughes,AR
DO  - 10.1111/adb.12457
EP  - 1609
PY  - 2016///
SN  - 1369-1600
SP  - 1601
TI  - Evidence for GABA-A receptor dysregulation in gambling disorder: correlation with impulsivity.
T2  - Addiction Biology
UR  - http://dx.doi.org/10.1111/adb.12457
UR  - http://hdl.handle.net/10044/1/39951
VL  - 22
ER  -
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